1. Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
  2. Reactive Oxygen Species
  3. Norgestrel

Norgestrel 

Cat. No.: HY-N7137
Handling Instructions

Norgestrel is a synthetic analog of progesterone, a compound commonly found in oral contraceptive pill, and a powerful neuroprotective antioxidant, preventing light-induced ROS in photoreceptor cells, and cell death.

For research use only. We do not sell to patients.

Norgestrel Chemical Structure

Norgestrel Chemical Structure

CAS No. : 6533-00-2

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Description

Norgestrel is a synthetic analog of progesterone, a compound commonly found in oral contraceptive pill, and a powerful neuroprotective antioxidant, preventing light-induced ROS in photoreceptor cells, and cell death[1][2].

In Vitro

Norgestrel (20 µM; 24 hours; 661W cells) treatment significantly increases cellular viability after serum deprivation and so it is demonstrated that Norgestrel is neuroprotective to stressed 661W cells[1].
Norgestrel (20 µM; 24 hours; 661W cells) treatment decreases apoptotic induced cleavage of PARP and caspase-3[1].
Norgestrel (20 µM; 6 hours; 661W cells) treatment bFGF is results in a significant upregulation of bFGF mRNA in photoreceptor cells[1].

Cell Viability Assay[1]

Cell Line: 661W cells
Concentration: 20 µM
Incubation Time: 24 hours
Result: Significantly increased cellular viability after serum deprivation.

Western Blot Analysis[1]

Cell Line: 661W cells
Concentration: 20 µM
Incubation Time: 24 hours
Result: Decreased apoptotic induced cleavage of PARP and caspase-3.

RT-PCR[1]

Cell Line: 661W cells
Concentration: 20 µM
Incubation Time: 6 hours
Result: A significant upregulation of bFGF mRNA over 1 hour.
In Vivo

Norgestrel (100 mg/kg; intraperitoneal injection; for 6, 24 or 48 hours; Balb/c mice) treatment can prevent light-induced ROS in photoreceptor cells, and subsequent cell death. Norgestrel acts via post-translational modulation of the major antioxidant transcription factor Nrf2; bringing about its phosphorylation, subsequent nuclear translocation, and increases levels of its effector protein superoxide dismutase 2 (SOD2)[2].

Animal Model: Balb/c mice are born into and maintained in dim cyclic light[2]
Dosage: 100 mg/kg;
Administration: Intraperitoneal injection; for 6, 24 or 48 hours
Result: Increased expression and activation of Nrf2 via phosphorylation on serine 40, increased expression of its target antioxidant superoxide dismutase 2 (SOD2), and reduced mitochondrial oxidative stress.
Molecular Weight

312.45

Formula

C₂₁H₂₈O₂

CAS No.

6533-00-2

SMILES

O=C1CC[[email protected]@]2([H])C(CC[[email protected]]3([H])[[email protected]]2([H])CC[[email protected]@]4(CC)[[email protected]@]3([H])CC[[email protected]]4(C#C)O)=C1.[relative stereochemistry]

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Please store the product under the recommended conditions in the Certificate of Analysis.

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