AL-438

Cat. No.: HY-114154: FAQs
Data Sheet Handling Instructions

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AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with K_is of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity.

For research use only. We do not sell to patients.

AL-438 Chemical Structure

CAS No. : 239066-73-0

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Description

IC₅₀ & Target

K_i: 2.5 nM (glucocorticoid receptor)^[1]

In Vitro

AL-438 (1 µM) decreases the LPS-induced IL-6 production in ATDC5 cells^[1].
AL-438 (0-1 µM; 1 h+24 h) inhibits IL-1β (2 ng/ml) induced IL-6 expression in HSKF1501 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AL-438 (1, 10, 100 mg/kg; p.o.) shows anti-inflammatory activity in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague Dawley rats (carrageenan paw edema model)^[2]
Dosage:	1, 10, 100 mg/kg
Administration:	P.o.
Result:	Showed antiinflammatory activity with ED₅₀ value of 11 mg/kg in acute inflammation assay.

Molecular Weight

347.45

Formula

C₂₃H₂₅NO₂

CAS No.

239066-73-0

SMILES

C=CCC1OC2=CC=CC(OC)=C2C3=C1C4=C(NC(C)(C)C=C4C)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Owen HC, et al. The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438. Mol Cell Endocrinol. 2007 Jan 29;264(1-2):164-70. [Content Brief]

[2]. Coghlan MJ, et al. A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects. Mol Endocrinol. 2003 May;17(5):860-9. [Content Brief]

AL-438 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AL-438239066-73-0AL438AL 438Glucocorticoid Receptororally activeosteocalcinantiinflammatoryATDC5 cellsHSKF1501 cellsInhibitorinhibitorinhibit

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