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Art. -Nr.: HY-114154

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AL-438

AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with K_is of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity.

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CAS. Nr.: 239066-73-0
Formel: C₂₃H₂₅NO₂
Molecular Weight:347.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

AL-438 Chemical Structure

CAS. Nr.: 239066-73-0

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Preis

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Menge

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

K_i: 2.5 nM (glucocorticoid receptor)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CV-1	EC₅₀	33 nM Compound: 18	Transcriptional activation in CV-1 cells expressing human glucocorticoid receptor Transcriptional activation in CV-1 cells expressing human glucocorticoid receptor	[PMID: 12620078]
HepG2	EC₅₀	13 nM Compound: 18	Transcriptional repression in HepG2 cells expressing human glucocorticoid receptor Transcriptional repression in HepG2 cells expressing human glucocorticoid receptor	[PMID: 12620078]

In Vitro

AL-438 (1 µM) decreases the LPS-induced IL-6 production in ATDC5 cells^[1].
AL-438 (0-1 µM; 1 h+24 h) inhibits IL-1β (2 ng/ml) induced IL-6 expression in HSKF1501 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AL-438 (1, 10, 100 mg/kg; p.o.) shows anti-inflammatory activity in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague Dawley rats (carrageenan paw edema model)^[2]
Dosage:

1, 10, 100 mg/kg
Administration:

P.o.
Result:

Showed antiinflammatory activity with ED₅₀ value of 11 mg/kg in acute inflammation assay.

Chemical Information

CAS. Nr. 239066-73-0
Molecular Weight 347.45
Formel C₂₃H₂₅NO₂
SMILES

C=CCC1OC2=CC=CC(OC)=C2C3=C1C4=C(NC(C)(C)C=C4C)C=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Owen HC, et al. The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438. Mol Cell Endocrinol. 2007 Jan 29;264(1-2):164-70. [Content Brief]

[2]. Coghlan MJ, et al. A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects. Mol Endocrinol. 2003 May;17(5):860-9. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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