1. Immunology/Inflammation Vitamin D Related/Nuclear Receptor
  2. Glucocorticoid Receptor
  3. AL-438

AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with Kis of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity.

For research use only. We do not sell to patients.

AL-438 Chemical Structure

AL-438 Chemical Structure

CAS No. : 239066-73-0

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Description

AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with Kis of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity[1][2].

IC50 & Target

Ki: 2.5 nM (glucocorticoid receptor)[1]

In Vitro

AL-438 (1 µM) decreases the LPS-induced IL-6 production in ATDC5 cells[1].
AL-438 (0-1 µM; 1 h+24 h) inhibits IL-1β (2 ng/ml) induced IL-6 expression in HSKF1501 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AL-438 (1, 10, 100 mg/kg; p.o.) shows anti-inflammatory activity in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats (carrageenan paw edema model)[2]
Dosage: 1, 10, 100 mg/kg
Administration: P.o.
Result: Showed antiinflammatory activity with ED50 value of 11 mg/kg in acute inflammation assay.
Molecular Weight

347.45

Formula

C23H25NO2

CAS No.
Unlabeled CAS

SMILES

C=CCC1OC2=CC=CC(OC)=C2C3=C1C4=C(NC(C)(C)C=C4C)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
AL-438
Cat. No.:
HY-114154
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