Tongkat Ali Extract
Based on 1 Customer Validation
Tongkat Ali Extract is the extract of Tongkat Ali, a testosterone modulator. Tongkat Ali Extract activates CYP17 enzyme to enhance conversion of pregnenolone and progesterone to dehydroepiandrosterone, androstenedione, and testosterone. Tongkat Ali Extract demonstrates antimalarial, antimicrobial, anticancer, and antidiabetic activity. Tongkat Ali Extract can be used for the research of diabetic and male infertility.
For research use only. We do not sell to patients.
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Storage:
RT, sealed storage, away from moisture and light.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Parasite Isoforms
More
Biological Activity
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CYP17 |
Tongkat Ali Extract (24 h) exhibits antibacterial activity against Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Salmonella typhi[5].
Tongkat Ali Extract (48 h) shows positive antifungal activity against C. albicans and A. fumigatus[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats (adult male, 300-350 g)[4]
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Dosage:200; 800 mg/kg
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Administration:p.o.; daily; 14 days
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Result:Decreased body weight by 5.7% at 800 mg/kg.
Decreased omentum fat mass by 31.9% at 800 mg/kg.
Increased serum testosterone concentration by 30.2% at 800 mg/kg.
Increased sperm concentration by 54.9% at 800 mg/kg.
Increased sperm vitality by 21.9% at 800 mg/kg.
Increased total sperm motility by 3.5% at 800 mg/kg.
Increased progressive sperm motility by 8.3% at 800 mg/kg.
Increased sperm velocity average path (VAP) by 11.2% at 800 mg/kg.
Increased sperm velocity curve line (VCL) by 10.6% at 800 mg/kg.
Increased sperm velocity straight line (VSL) by 13.2% at 800 mg/kg.
Increased sperm with intact mitochondrial membrane potential by 25.1% at 800 mg/kg.
Decreased body weight significantly at 200 mg/kg.
Decreased omentum fat mass at 200 mg/kg.
Increased sperm concentration, vitality, total motility, progressive motility, VAP, VCL, and VSL significantly at 200 mg/kg.
Showed no significant changes in testes, epididymides, prostate, or gastrocnemius muscle weights at either dose.
Detected no effect on acrosome reaction status at either dose.
Chemical Information
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Appearance Solid
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Color Yellow to brown
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SMILES
[Tongkat Ali Extract]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
RT, sealed storage, away from moisture and light
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
DMSO : 25 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL; Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL; Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[4]. Solomon MC, et al. In vivo effects of Eurycoma longifolia Jack (Tongkat Ali) extract on reproductive functions in the rat. Andrologia. 2014 May;46(4):339-48. [Content Brief]
[5]. Latip MQA, et al. A Systematic Review on Antimicrobial and Antiparasitic Activity of Eurycoma longifolia Jack (Tongkat Ali). Biomed Res Int. 2022 Jul 6;2022:4999797. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tongkat Ali Extract Related Classifications
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