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Results for "

antimalarial+activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (1) Acyltransferase (1) ADC Payload (1) AMPK (3) Antibiotic (10) Apoptosis (13) Autophagy (2) Bacterial (24) CD47 (1) CDK (1) Cholinesterase (ChE) (1) CXCR (1) Dihydrofolate reductase (DHFR) (2) Dihydroorotate Dehydrogenase (3) DNA/RNA Synthesis (6) Drug Derivative (1) Drug Intermediate (1) Drug Metabolite (3) Endogenous Metabolite (3) Enolase (1) Epigenetic Reader Domain (1) Fatty Acid Synthase (FASN) (1) Ferroptosis (1) FOXO (2) Fungal (6) HDAC (6) Histamine Receptor (2) Hydroxycarboxylic Acid Receptor (HCAR) (1) Interleukin Related (2) Isotope-Labeled Compounds (1) JNK (2) Lactate Dehydrogenase (1) LOX-1 (1) MAP4K (1) MDM-2/p53 (4) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) NF-κB (4) Parasite (115) PDGFR (1) PI3K (1) PI4K (2) PKA (1) Potassium Channel (4) Reactive Oxygen Species (ROS) (6) Reference Standards (12) Serotonin Transporter (2) Sirtuin (1) Syk (1) Thymidylate Synthase (3) TMV (1) TrxR (1)
By Research Areas:	Cancer (25) Cardiovascular Disease (1) Infection (120) Inflammation/Immunology (11) Metabolic Disease (3) Neurological Disease (5)

By Targets:

Acetyl-CoA Carboxylase (1)

Acyltransferase (1)

ADC Payload (1)

AMPK (3)

Antibiotic (10)

Apoptosis (13)

Autophagy (2)

Bacterial (24)

CD47 (1)

CDK (1)

Cholinesterase (ChE) (1)

CXCR (1)

Dihydrofolate reductase (DHFR) (2)

Dihydroorotate Dehydrogenase (3)

DNA/RNA Synthesis (6)

Drug Derivative (1)

Drug Intermediate (1)

Drug Metabolite (3)

Endogenous Metabolite (3)

Enolase (1)

Epigenetic Reader Domain (1)

Fatty Acid Synthase (FASN) (1)

Ferroptosis (1)

FOXO (2)

Fungal (6)

HDAC (6)

Histamine Receptor (2)

Hydroxycarboxylic Acid Receptor (HCAR) (1)

Interleukin Related (2)

Isotope-Labeled Compounds (1)

JNK (2)

Lactate Dehydrogenase (1)

LOX-1 (1)

MAP4K (1)

MDM-2/p53 (4)

Microtubule/Tubulin (1)

Mitochondrial Metabolism (1)

NF-κB (4)

Parasite (115)

PDGFR (1)

PI3K (1)

PI4K (2)

PKA (1)

Potassium Channel (4)

Reactive Oxygen Species (ROS) (6)

Reference Standards (12)

Serotonin Transporter (2)

Sirtuin (1)

Syk (1)

Thymidylate Synthase (3)

TMV (1)

TrxR (1)

By Research Areas:

Cancer (25)

Cardiovascular Disease (1)

Infection (120)

Inflammation/Immunology (11)

Metabolic Disease (3)

Neurological Disease (5)

131

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W016819

5-Fluoroorotic acid	Thymidylate Synthase Parasite	Infection
5-Fluoroorotic acid is the inhibitor for thymidylate synthase that acts as a selective agent in yeast molecular genetics. 5-Fluoroorotic acid exhibits antimalarial activity .

HY-N0941

beta-Mangostin 4 Publications Verification β-Mangostin	Bacterial Parasite Apoptosis	Infection Cancer
beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC₅₀ of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic) .

HY-B0273

Sulfadiazine 5+ Cited Publications	Bacterial Parasite Antibiotic	Infection
Sulfadiazine is a sulfonamide antibiotic with antimalarial activity. Sulfadiazine can be used for toxoplasmosis research .

HY-N8290

Lactupicrin Lactucopicrin	LOX-1 NF-κB Cholinesterase (ChE) Parasite	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
Lactupicrin (Lactucopicrin) exhibits analgesic, sedative, antimalarial activities and atheroprotective effect. Lactupicrin inhibits acetylcholinesterase (AChE) with an IC₅₀ of 150.3 μM. Lactupicrin is an orally active characteristic bitter sesquiterpene lactone .

HY-B0770

Artemotil 1 Publications Verification β-Arteether; (+)-Arteether; Arteether	CXCR Parasite	Infection Cancer
Artemotil (β-Arteether) has antimalarial activity for the treatment of chloroquine-resistant *Plasmodium falciparum* malaria with an IC₅₀ of 1.61 nM. Artemotil also has central nervous system (CNS) neurotoxicity and anorectic toxicity in rats, dogs and monkeys .

HY-N1984

Artemisic acid Qing Hao acid; Artemisinic acid; Arteannuic acid	JNK Interleukin Related	Infection Metabolic Disease Inflammation/Immunology Cancer
Artemisinic acid (Qing Hao acid) is a sesquiterpene that can be isolated from Artemisia annua L. Artemisinic acid is also an important precursor for the synthesis of Artemisinin (HY-B0094). Artemisinic acid has various pharmacological activities, such as antimalarial activity, antitumor activity, antipyretic effect, antibacterial activity, allelopathic effect, and anti-adipogenic effect .

HY-32004

Coumalic acid	Endogenous Metabolite Parasite Hydroxycarboxylic Acid Receptor (HCAR)	Infection
Coumalic acid is an inhibitor of human carbonic anhydrase (hCA) (K_I = 0.073 μM for hCA IX; K_I = 0.083 μM for hCA XII). Coumalic acid is a valuable platform compound which can be prepared from malic acid. Coumalic acid can be used in the flavorings, fragrances and cosmetics industries, as polymer components, and pharmaceutical scaffolds. Coumalic acid displays antibronchial and antimalarial activity .

HY-B0273A

Sulfadiazine sodium 5+ Cited Publications	Bacterial Parasite Antibiotic	Infection
Sulfadiazine sodium is a sulfonamide antibiotic with antimalarial activity. Sulfadiazine can be used for toxoplasmosis research .

HY-W016819B

5-Fluoroorotic acid monohydrate 5-Fluorouracil-6-carboxylic acid Monohydrate; 5-FOA; 5-fluoro OA	Thymidylate Synthase Parasite	Infection
5-Fluoroorotic acid monohydrate is the monohydrate salt form of 5-Fluoroorotic acid (HY-W016819). 5-Fluoroorotic acid monohydrate is the inhibitor for thymidylate synthase that acts as a selective agent in yeast molecular genetics. 5-Fluoroorotic acid monohydrate exhibits antimalarial activity .

HY-136429A

Ethylhydrocupreine hydrochloride Optochin hydrochloride	Bacterial Parasite	Infection
Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against *S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity* against *Plasmodium falciparum, with an IC₅₀* of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist .

HY-118494

Ascaridole	Parasite	Infection
Ascaridole is an anthelmintic and also has antimalarial activity .

HY-N9438

Lactucin	Apoptosis Parasite	Infection Inflammation/Immunology Cancer
Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities .

HY-N2384

Febrifugine	Parasite DNA/RNA Synthesis Apoptosis	Infection Cancer
Febrifugine is a quinazolinone alkaloid that inhibits *P. falciparum* and has antimalarial activity. Febrifugine inhibits bladder cancer by inhibiting DNA synthesis, inducing apoptosis, and reducing steroids .

HY-N2384A

Febrifugine dihydrochloride	Parasite DNA/RNA Synthesis Apoptosis	Infection Cancer
Febrifugine dihydrochloride is a quinazolinone alkaloid that inhibits *P. falciparum* and has antimalarial activity. Febrifugine dihydrochloride inhibits bladder cancer by inhibiting DNA synthesis, inducing apoptosis, and reducing steroids .

HY-108640A

HLI373 dihydrochloride	MDM-2/p53 Parasite Apoptosis	Infection Cancer
HLI373 dihydrochloride is an efficacious Hdm2 inhibitor. HLI373 dihydrochloride inhibits the ubiquitin ligase activity of Hdm2. HLI373 dihydrochloride is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents . *Antimalarial* activity .

HY-P3914

Cecropin A (1-7)-Melittin A (2-9) Oct-CA(1-7)M(2-9)	Bacterial	Infection
Cecropin A (1-7)-Melittin A (2-9) is an antimicrobial peptide with antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative aerobic bacteria, as well as antimalarial activity, without the adverse hemolytic properties of bee venom peptides .

HY-136767

Cladosporin	Antibiotic Fungal Bacterial Parasite DNA/RNA Synthesis	Infection
Cladosporin is an antibiotic and an an antifungal metabolite that can be produced in good yield in the mycelium of Cladosporium cladosporioid. Cladosporin exhibits inhibitory activity against various dermatophytes, plant pathogens, and bacteria. Cladosporin also exhibits antimalarial activity through inhibition of cytoplasmic lysine-tRNA synthetase of Plasmodium (PfKrs1) .

HY-122394

Thiolactomycin	Antibiotic Bacterial Fatty Acid Synthase (FASN)	Infection
Thiolactomycin is an orally active bacterial type II fatty acid synthase (FAS-II) inhibitor with antibacterial and antimalarial activities. Thiolactomycin specifically targets KasA/KasB in mycobacteria and FabB/FabF in bacteria, thereby inhibiting the biosynthesis of fatty acids and mycolic acids. Thiolactomycin can be used in studies related to tuberculosis, systemic bacterial infections, and experimental pyelonephritis .

HY-N5018

Nepodin Musizin	Parasite AMPK	Infection
Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

HY-117015

Purfalcamine	Parasite	Infection
Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC₅₀ of 17 nM and an EC₅₀ of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage .

HY-P10338

LZ1 peptide	Bacterial Antibiotic	Infection
LZ1 peptide is a antimicrobial peptides with antimalarial activity .

HY-135648

PfDHODH-IN-1	Parasite Lactate Dehydrogenase DNA/RNA Synthesis	Infection
PfDHODH-IN-1 is an analogue of the active metabolite of Leflunomide. PfDHODH-IN-1 is a Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor. PfDHODH-IN-1 has antimalarial activity .

HY-W012192

trans,trans-Dibenzylideneacetone (E,E)-Dibenzylideneacetone; trans,trans-Dibenzalacetone	Parasite	Infection
trans,trans-Dibenzylideneacetone ((E,E)-Dibenzylideneacetone) (compound A1) is a dibenzylideneacetone with a week antimalarial activity. trans,trans-Dibenzylideneacetone inhibits P. falciparum 3D7 strain with an IC₅₀ of 213.41 μM .

HY-N7642

Oxysanguinarine Hydroxysanguinarine; 8-Oxosanguinarine	Parasite	Infection
Oxysanguinarine (Hydroxysanguinarine;8-Oxosanguinarine) is a protoberberine alkaloid from Meconopsis simplicifolia with *antimalarial* activity .

HY-W612975

4-Dodecylmorpholine	Parasite	Others
4-Dodecylmorpholine (DMP) is a surfactant with antimalarial activity. It can be used as a hydrophilic enzyme detergent and is commonly used as an extraction collector in reverse foam preparation processes .

HY-B0273R

Sulfadiazine (Standard)	Reference Standards Bacterial Parasite Antibiotic	Infection
Sulfadiazine (Standard) is the analytical standard of Sulfadiazine. This product is intended for research and analytical applications. Sulfadiazine is a sulfonamide antibiotic with antimalarial activity. Sulfadiazine can be used for toxoplasmosis research .

HY-P2261

STAD 2 1 Publications Verification	PKA	Infection
STAD 2 is a potent and selective disruptor of PKA-RII, with a K_d of 6.2 nM. STAD 2 disrupts interactions between PKA and AKAP in an isoform-selective manner. STAD 2 displays antimalarial activity through a PKA-independent mechanism .

HY-N9438R

Lactucin (Standard)	Reference Standards Apoptosis Parasite	Infection Inflammation/Immunology Cancer
Lactucin (Standard) is the analytical standard of Lactucin. This product is intended for research and analytical applications. Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities [4].

HY-108640

HLI373	MDM-2/p53 Parasite Apoptosis	Infection Cancer
HLI373 is an efficacious Hdm2 inhibitor. HLI373 inhibits the ubiquitin ligase activity of Hdm2. HLI373 is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents . *Antimalarial* activity .

HY-135619

DHODH-IN-4	Parasite Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Infection Inflammation/Immunology
DHODH-IN-4 (compound 17) is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor, with IC₅₀ values of 4 μM and 0.18 μM for PfDHODH and HsDHODH, respectively. DHODH-IN-4 (compound 17) possess antimalarial activity .

HY-135652

Hexyl gallate Hexyl 3,4,5-trihydroxybenzoate	Bacterial Parasite	Infection
Hexyl gallates (Hexyl 3,4,5-trihydroxybenzoate) shows antibacterial activity and inhibits the production of rhamnolipid and pyocyanin by inhibiting RhlR . Hexyl gallate, a alkyl ester derivative of gallic acid, exhibits potent antimalarial activity against Plasmodium falciparum, with IC₅₀ of 0.11 mM .

HY-136429

Ethylhydrocupreine Optochin	Bacterial Parasite	Infection
Ethylhydrocupreine (Optochin) is a quinine derivate with antimicrobial activity against *S. pneumoniae. Ethylhydrocupreine also possesses antimalarial activity* against *Plasmodium falciparum, with an IC₅₀* of 25.75 nM. Ethylhydrocupreine is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist .

HY-145431

(S)-GSK1379725A	Epigenetic Reader Domain Parasite	Infection
(S)-GSK1379725A (compound AU1) is a selective bromodomain and PHD finger containing transcription factor (BPTF) bromodomain inhibitor with a K_d of 2.8 μM. (S)-GSK1379725A shows to be selective for BPTF over BRD4 bromodomain. (S)-GSK1379725A shows antimalarial activity .

HY-100033

NSC5844 RE-640	Parasite	Infection Cancer
NSC5844 (RE-640) is a 4-aminoquinoline derivative, with antitumor and *antimalarial* activity.

HY-186054

Antimalarial agent 57	Parasite	Infection
Antimalarial agent 57 (308470) is a quinoline methanol derivative with antimalarial activity. Antimalarial agent 57 can be used in malaria research .

HY-101672

Deferitazole FBS 0701	Ferroptosis Parasite	Infection
Deferitazole (FBS 0701) is an orally active iron chelator. Deferitazole shows antimalarial activity and Can be used for study of malaria .

HY-W009194

(R)-(+)-Trityl glycidyl ether	Drug Intermediate	Infection
(R)-(+)-Trityl glycidyl ether, a heterocyclic compound, is a precursor that can be used to synthesize glycerophospholipids, as well as compounds with antiviral and antimalarial activities .

HY-N7314

Asebogenin	Syk	Inflammation/Immunology
Asebogenin has antimalarial activity in vitro . Asebogenin can inhibit the phosphorylation of Syk, thereby effectively suppressing platelet activation and the formation of neutrophil extracellular traps .

HY-W016819R

5-Fluoroorotic acid (Standard)	Reference Standards Thymidylate Synthase Parasite	Infection
5-Fluoroorotic acid is the inhibitor for thymidylate synthase that acts as a selective agent in yeast molecular genetics. 5-Fluoroorotic acid exhibits antimalarial activity .

HY-N7281

Aphadilactone C	Acyltransferase Parasite	Infection
Aphadilactone C is a potent and selective DGAT-1 inhibitor with an IC₅₀ of 0.46 μM. Aphadilactone C shows significant antimalarial activities with an IC₅₀ value of 170 nM .

HY-116713

PfDHODH-IN-3	Parasite Dihydroorotate Dehydrogenase	Infection
PfDHODH-IN-3 (compound 2) is an orally active PfDHODH inhibitor with strong antimalarial activity (IC₅₀=47 nM). PfDHODH-IN-3 can inhibit the growth of Plasmodium in animals .

HY-N2876

Anisofolin A	Parasite Bacterial	Infection
Anisofolin A is a flavonoid that can be isolated from Anisomeles indica. Anisofolin A has antimalarial activity (IC₅₀: 4.39 μM), and antimycobacterium activity (IC₅₀: 4.50 μM) against M. tuberculosis H37Ra .

HY-121273

Diclofop Dichlorfop acid; (±)-Diclofop	Acetyl-CoA Carboxylase Parasite Drug Metabolite	Infection
Diclofop (Dichlorfop acid) is an acetyl-CoA carboxylase (ACC) inhibitor. Diclofop is also the major metabolite of the herbicide Diclofop-methyl (HY-136367). Diclofop exhibits antimalarial activity with an IC₅₀ of 210 μM against P. falciparum .

HY-W011241

Cinchonine hydrochloride (8R,9S)-Cinchonine hydrochloride; LA40221 hydrochloride	Apoptosis Parasite	Cancer
Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural alkaloid present in Cinchona bark, with antimalarial activity. Cinchonine hydrochloride activates endoplasmic reticulum (ER) stress-induced apoptosis in human liver cancer cells .

HY-121556

Rufigallol	Reactive Oxygen Species (ROS) Parasite	Infection
Rufigallol is one of the earliest systems reported to form columnar mesophases. Rufigallol is also an oxidant agent. Rufigallol acts in a pro-oxidant fashion to produce oxygen radicals inside parasitized erythrocytes. Rufigallol has vitamin K activity and antimalarial activity .

HY-106338

Polyketomycin	Bacterial ADC Payload Parasite	Infection Cancer
Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities .

HY-135666

DHODH-IN-8	Parasite Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Infection
DHODH-IN-8 (Compound 27) is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC₅₀s of 0.13 μM and 47.4 μM, and K_is of 0.016 μM and 5.6 μM, respectively. DHODH-IN-8 has antimalarial activity .

HY-N8290R

Lactupicrin (Standard) Lactucopicrin (Standard)	Autophagy NF-κB AMPK Reference Standards	Neurological Disease Metabolic Disease
Lactupicrin (Standard) is the analytical standard of Lactupicrin. This product is intended for research and analytical applications. Lactupicrin (Lactucopicrin) exhibits analgesic, sedative, antimalarial activities and atheroprotective effect. Lactupicrin inhibits acetylcholinesterase (AChE) with an IC₅₀ of 150.3 μM. Lactupicrin is an orally active characteristic bitter sesquiterpene lactone .

HY-124127

Allylpyrocatechol	Parasite	Others
Allylpyrocatechol is a compound with antimalarial activity isolated from plants. Its antimalarial activity in vitro and in vivo has been verified, and structure-activity relationship analysis of its analogs has also been performed.

HY-12781

Desbutyl Lumefantrine Desbutyl-benflumetol	Drug Metabolite	Infection
Desbutyl Lumefantrine is a metabolite of lumefantrine with antimalarial activity .

Cat. No.	Product Name	Target	Research Area

HY-P3914

Cecropin A (1-7)-Melittin A (2-9) Oct-CA(1-7)M(2-9)	Bacterial	Infection
Cecropin A (1-7)-Melittin A (2-9) is an antimicrobial peptide with antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative aerobic bacteria, as well as antimalarial activity, without the adverse hemolytic properties of bee venom peptides .

HY-P10338

LZ1 peptide	Bacterial Antibiotic	Infection
LZ1 peptide is a antimicrobial peptides with antimalarial activity .

HY-P2261

STAD 2 1 Publications Verification	PKA	Infection
STAD 2 is a potent and selective disruptor of PKA-RII, with a K_d of 6.2 nM. STAD 2 disrupts interactions between PKA and AKAP in an isoform-selective manner. STAD 2 displays antimalarial activity through a PKA-independent mechanism .

HY-P1638

Isariin A	Parasite	Infection
Isariin A is a cyclodepsipeptide isolated from the fungus Isaria cretacea, which exhibits antimalarial activity .

HY-P1992

Isariin B	Parasite	Infection
Isariin B is a cyclodepsipeptide isolated from the fungus Isaria felina, which exhibits antimalarial activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0941

beta-Mangostin 4 Publications Verification β-Mangostin	Infection Xanthones Classification of Application Fields Guttiferae Phenols Polyphenols Garcinia mangostana Linn. Plants Disease Research Fields Source Classification Cancer	Bacterial Parasite Apoptosis
beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC₅₀ of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic) .

HY-N0173

Cinchonidine α-Quinidine	Infection Alkaloids Piperidine Alkaloids Structural Classification Cinchona officinalis Linn. Classification of Application Fields Rubiaceae Quinoline Alkaloids Plants Disease Research Fields	Serotonin Transporter Parasite
Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. A building block used in asymmetric synthesis in organic chemistry. Weak inhibitor of serotonin transporter (SERT) with K_is of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. Antimalarial activities .

HY-N6742

Borrelidin 1 Publications Verification Treponemycin	Infection Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Anti-parasitic Antibacterial Disease Research Disease Research Fields Source Classification	CDK Parasite Apoptosis Antibiotic
Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei . Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC₅₀ of 24 μM . Borrelidin is a potent angiogenesis inhibitor, with an IC₅₀ of 0.8 nM. Borrelidin induces apoptosis in the tube-forming cells . Borrelidin has strong antimalarial activities, with IC₅₀s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum, respectively .

HY-N8290

Lactupicrin Lactucopicrin	Monophenols Terpenoids Genista quadriflora Munby Sesquiterpenes Phenols Plants Compositae Source Classification	LOX-1 NF-κB Cholinesterase (ChE) Parasite
Lactupicrin (Lactucopicrin) exhibits analgesic, sedative, antimalarial activities and atheroprotective effect. Lactupicrin inhibits acetylcholinesterase (AChE) with an IC₅₀ of 150.3 μM. Lactupicrin is an orally active characteristic bitter sesquiterpene lactone .

HY-B0770

Artemotil 1 Publications Verification β-Arteether; (+)-Arteether; Arteether	Natural Products Classification of Application Fields Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Disease Research Fields Source Classification Cancer	CXCR Parasite
Artemotil (β-Arteether) has antimalarial activity for the treatment of chloroquine-resistant *Plasmodium falciparum* malaria with an IC₅₀ of 1.61 nM. Artemotil also has central nervous system (CNS) neurotoxicity and anorectic toxicity in rats, dogs and monkeys .

HY-N1984

Artemisic acid Qing Hao acid; Artemisinic acid; Arteannuic acid	Infection Classification of Application Fields Terpenoids Sesquiterpenes Artemisia carvifolia Buch.-Ham. ex Roxb. Metabolic Disease Plants Compositae Inflammation/Immunology Disease Research Fields Source Classification	JNK Interleukin Related
Artemisinic acid (Qing Hao acid) is a sesquiterpene that can be isolated from Artemisia annua L. Artemisinic acid is also an important precursor for the synthesis of Artemisinin (HY-B0094). Artemisinic acid has various pharmacological activities, such as antimalarial activity, antitumor activity, antipyretic effect, antibacterial activity, allelopathic effect, and anti-adipogenic effect .

HY-32004

Coumalic acid	Structural Classification Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Smilacis Glabrae Rhizoma Plants Disease Research Fields Source Classification	Endogenous Metabolite Parasite Hydroxycarboxylic Acid Receptor (HCAR)
Coumalic acid is an inhibitor of human carbonic anhydrase (hCA) (K_I = 0.073 μM for hCA IX; K_I = 0.083 μM for hCA XII). Coumalic acid is a valuable platform compound which can be prepared from malic acid. Coumalic acid can be used in the flavorings, fragrances and cosmetics industries, as polymer components, and pharmaceutical scaffolds. Coumalic acid displays antibronchial and antimalarial activity .

HY-107566

Conessine	Infection other families Classification of Application Fields Plants Disease Research Fields Steroids Source Classification	Histamine Receptor Parasite MDM-2/p53 NF-κB FOXO Bacterial
Conessine is an orally active and BBB-penetrable selective histamine H3 receptor antagonist. The pK_i values of Conessine for rat and human H3 receptors are 7.61 and 8.27, respectively. Conessine is an inhibitor of the multidrug efflux pump system in Pseudomonas aeruginosa and can enhance the activity of antibiotics. Conessine has antimalarial activity. Conessine can also be used in the research of muscle atrophy .

HY-N2416

Taccalonolide A	Classification of Application Fields Plants Disease Research Fields Tacca chantrieri Andre Taccaceae Steroids Cancer Source Classification	Microtubule/Tubulin Apoptosis
Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities . Taccalonolide A causes G₂-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis . Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC₅₀ of 622 nM for SK-OV-3 cells .

HY-118494

Ascaridole	Natural Products Plants Dysphania ambrosioides (Linnaeus) Mosyakin & Clemants Source Classification Chenopodiaceae	Parasite
Ascaridole is an anthelmintic and also has antimalarial activity .

HY-N9438

Lactucin	Iridoids Genista quadriflora Munby Plants Compositae Source Classification	Apoptosis Parasite
Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities .

HY-N2384

Febrifugine	Infection Alkaloids Classification of Application Fields Dichroa febrifuga Lour Pyridine Alkaloids Saxifragaceae Plants Disease Research Fields Source Classification	Parasite DNA/RNA Synthesis Apoptosis
Febrifugine is a quinazolinone alkaloid that inhibits *P. falciparum* and has antimalarial activity. Febrifugine inhibits bladder cancer by inhibiting DNA synthesis, inducing apoptosis, and reducing steroids .

HY-N2384A

Febrifugine dihydrochloride	Infection Alkaloids Classification of Application Fields Dichroa febrifuga Lour Pyridine Alkaloids Saxifragaceae Plants Disease Research Fields Source Classification	Parasite DNA/RNA Synthesis Apoptosis
Febrifugine dihydrochloride is a quinazolinone alkaloid that inhibits *P. falciparum* and has antimalarial activity. Febrifugine dihydrochloride inhibits bladder cancer by inhibiting DNA synthesis, inducing apoptosis, and reducing steroids .

HY-136767

Cladosporin	Infection Microorganisms Classification of Application Fields Phenols Polyphenols Disease Research Fields Source Classification	Antibiotic Fungal Bacterial Parasite DNA/RNA Synthesis
Cladosporin is an antibiotic and an an antifungal metabolite that can be produced in good yield in the mycelium of Cladosporium cladosporioid. Cladosporin exhibits inhibitory activity against various dermatophytes, plant pathogens, and bacteria. Cladosporin also exhibits antimalarial activity through inhibition of cytoplasmic lysine-tRNA synthetase of Plasmodium (PfKrs1) .

HY-N5018

Nepodin Musizin	Rumex crispus Linn. Infection Structural Classification Classification of Application Fields Polygonaceae Phenols Polyphenols Rumex japonicus Houtt. Plants Disease Research Fields Source Classification	Parasite AMPK
Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

HY-N7642

Oxysanguinarine Hydroxysanguinarine; 8-Oxosanguinarine	Infection Alkaloids other families Classification of Application Fields Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Parasite
Oxysanguinarine (Hydroxysanguinarine;8-Oxosanguinarine) is a protoberberine alkaloid from Meconopsis simplicifolia with *antimalarial* activity .

HY-N9438R

Lactucin (Standard)	Iridoids Genista quadriflora Munby Plants Compositae Source Classification	Reference Standards Apoptosis Parasite
Lactucin (Standard) is the analytical standard of Lactucin. This product is intended for research and analytical applications. Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities [4].

HY-N0173R

Cinchonidine (Standard) α-Quinidine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Cinchona officinalis Linn. Rubiaceae Quinoline Alkaloids Plants	Reference Standards Serotonin Transporter Parasite
Cinchonidine (Standard) is the analytical standard of Cinchonidine. This product is intended for research and analytical applications. Cinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. A building block used in asymmetric synthesis in organic chemistry. Weak inhibitor of serotonin transporter (SERT) with Kis of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. Antimalarial activities .

HY-134914

Fosmidomycin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Parasite
Fosmidomycin is an orally active antibiotic, which exhibits antimalarial activity through inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DOXP reductoisomerase). Fosmidomycin inhibits P. falciparum strains 3D7, HB3, Dd2 and A2, with IC₅₀s of 150, 71, 170 and 150 ng/mL, respectively. Fosmidomycin exhibits synergistic effect with Clindamycin (HY-B1455), and ameliorates malaria in mouse model .

HY-N7314

Asebogenin	Glycosmis parviflora Kurz. Phenols Polyphenols Plants Salicaceae Source Classification	Syk
Asebogenin has antimalarial activity in vitro . Asebogenin can inhibit the phosphorylation of Syk, thereby effectively suppressing platelet activation and the formation of neutrophil extracellular traps .

HY-N7281

Aphadilactone C	Terpenoids Diterpenoids Plants Meliaceae Aphanamixis polystachya (Wall.) R. N. Parker Source Classification	Acyltransferase Parasite
Aphadilactone C is a potent and selective DGAT-1 inhibitor with an IC₅₀ of 0.46 μM. Aphadilactone C shows significant antimalarial activities with an IC₅₀ value of 170 nM .

HY-N2876

Anisofolin A	Monophenols Flavonoids Flavones Labiatae Phenols Plants Artemisia persica Boiss. Source Classification	Parasite Bacterial
Anisofolin A is a flavonoid that can be isolated from Anisomeles indica. Anisofolin A has antimalarial activity (IC₅₀: 4.39 μM), and antimycobacterium activity (IC₅₀: 4.50 μM) against M. tuberculosis H37Ra .

HY-W011241

Cinchonine hydrochloride (8R,9S)-Cinchonine hydrochloride; LA40221 hydrochloride	Alkaloids other families Classification of Application Fields Quinoline Alkaloids Plants Disease Research Fields Cancer Source Classification	Apoptosis Parasite
Cinchonine hydrochloride ((8R,9S)-Cinchonine hydrochloride) is a natural alkaloid present in Cinchona bark, with antimalarial activity. Cinchonine hydrochloride activates endoplasmic reticulum (ER) stress-induced apoptosis in human liver cancer cells .

HY-106338

Polyketomycin	Infection Quinones Microorganisms Classification of Application Fields Phenols Polyphenols Naphthalene Quinones Disease Research Fields Source Classification	Bacterial ADC Payload Parasite
Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities .

HY-N8290R

Lactupicrin (Standard) Lactucopicrin (Standard)	Structural Classification Monophenols Terpenoids Genista quadriflora Munby Sesquiterpenes Phenols Plants Compositae Source Classification	Autophagy NF-κB AMPK Reference Standards
Lactupicrin (Standard) is the analytical standard of Lactupicrin. This product is intended for research and analytical applications. Lactupicrin (Lactucopicrin) exhibits analgesic, sedative, antimalarial activities and atheroprotective effect. Lactupicrin inhibits acetylcholinesterase (AChE) with an IC₅₀ of 150.3 μM. Lactupicrin is an orally active characteristic bitter sesquiterpene lactone .

HY-N1984R

Artemisic acid (Standard) Qing Hao acid (Standard); Artemisinic acid (Standard); Arteannuic acid (Standard)	Structural Classification Terpenoids Sesquiterpenes Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Source Classification	Reference Standards JNK Interleukin Related
Artemisic acid (Standard) (Qing Hao acid (Standard)) is the analytical standard of Artemisic acid (HY-N1984). This product is intended for research and analytical applications. Artemisinic acid (Qing Hao acid) is a sesquiterpene that can be isolated from Artemisia annua L. Artemisinic acid is also an important precursor for the synthesis of Artemisinin (HY-B0094). Artemisinic acid has various pharmacological activities, such as antimalarial activity, antitumor activity, antipyretic effect, antibacterial activity, allelopathic effect, and anti-adipogenic effect .

HY-158721

Penicinoline Marinamide	Structural Classification Alkaloids Microorganisms Indole Alkaloids Source Classification	Endogenous Metabolite Parasite
Penicinoline (Marinamide) (Compound 1), a pyrrolyl 4-quinolinone alkaloid, is a microbial secondary metabolite. Penicinoline can be isolated from endophytic fungus Penicillium sp. Penicinoline has antimalarial activity against Chloroquine (HY-17589A) sensitive strain (pf3d7) and against Chloroquine resistant strain (pfDd2) of plasmodium falciparum. Penicinoline also has strong insecticidal activity against Aphis gossypii and selective anticancer effect with significant cytotoxicity for 95-D and HepG2 cells .

HY-P1638

Isariin A	Microorganisms Cyclopeptides Source Classification	Parasite
Isariin A is a cyclodepsipeptide isolated from the fungus Isaria cretacea, which exhibits antimalarial activity .

HY-N1075

Walsuronoid B	Triterpenes Terpenoids Plants Meliaceae Walsura robusta Roxb. Source Classification	Parasite
Walsuronoid B is a limonoid can be isolated from Walsura robusta and has weak antimalarial activity .

HY-P1992

Isariin B	Microorganisms Cyclopeptides Source Classification	Parasite
Isariin B is a cyclodepsipeptide isolated from the fungus Isaria felina, which exhibits antimalarial activity .

HY-118494R

Ascaridole (Standard)	Structural Classification Natural Products Plants Dysphania ambrosioides (Linnaeus) Mosyakin & Clemants Chenopodiaceae Source Classification	Parasite Reference Standards
Ascaridole (Standard) is the analytical standard of Ascaridole. This product is intended for research and analytical applications. Ascaridole is an anthelmintic and also has antimalarial activity .

HY-N15187

Acronycidine	Alkaloids Microorganisms Other Alkaloids Source Classification	Parasite
Acronycidine is a quinoline alkaloid with *antimalarial* activity and can be extracted from Acronychia baueri Schott. Acronycidine can be utilized in malari research .

HY-N16640

Anol glucoside	Structural Classification Cleidion spiciflorum (Burm. f.) Merr. Euphorbiaceae Plants Saccharides Monosaccharides Source Classification	Bacterial Parasite
Anol glucoside is a phenolic glucose glycoside compound found in Cleidion spiciflorum. Anol glucoside has potential antibacterial, anti-inflammatory and antimalarial activities .

HY-N2753

7-Acetoxybonducellpin C	Leguminosae Caesalpinia crista L. Terpenoids Diterpenoids Plants Source Classification	Parasite
7-Acetoxybonducellpin C, a diterpenoid, is a nature product that could be isolated from the seed kernels of Caesalpinia crista. 7-Acetoxybonducellpin C has antimalarial activity .

HY-N8338

Pancixanthone A	Flavonoids Guttiferae Garcinia vieillardii Pierre Plants Other Flavonoids Source Classification	Parasite
Pancixanthone A is a xanthone that can be isolated from Garcinia vieillardii. Pancixanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC₅₀ of 1.6 μg/mL .

HY-N8455

Isocudraniaxanthone A Assiguxanthone A	Flavonoids Xanthones Calophyllum caledonicum Vieill. ex Planch. & Triana Phenols Plants Calophyllaceae Other Flavonoids Source Classification	Parasite
Isocudraniaxanthone A is a xanthone that can be isolated from Garcinia vieillardii. Isocudraniaxanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC₅₀ of 2.3 μg/mL .

HY-N14309

Astechrome	Natural Products Microorganisms Source Classification	Parasite
Astechrome is a natural product with a strong antimalarial activity with an IC₅₀ value of 0.94 μM. Astechrome exhibits cytotoxicity against Vero cells with IC₅₀ value of 7.9 μM .

HY-N3957

1-(26-Hydroxyhexacosanoyl)-glycerol	Natural Products Rourea minor (Gaerth.) Leenh. Plants Connaraceae Source Classification	Parasite
1-(26-Hydroxyhexacosanoyl)-glycerol is a potent antimalarial agent. 1-(26-Hydroxyhexacosanoyl)-glycerol shows antimalarial activity with an IC₅₀ value of 9.48 µM for Plasmodium falciparum .

HY-N2759

7-O-Isopentenyl-γ-fagarine	Alkaloids Peltostigma guatemalense (Standl. & Steyerm.) Gereau Rutaceae Quinoline Alkaloids Plants Source Classification	Bacterial
7-O-Isopentenyl-γ-fagarine is an alkaloid that can be isolated from Peltostigma guatemalense. 7-O-Isopentenyl-γ-fagarine has antibacterial and antimalarial activities in vitro .

HY-N0941R

beta-Mangostin (Standard) β-Mangostin (Standard)	Structural Classification Xanthones Guttiferae Phenols Polyphenols Garcinia mangostana Linn. Plants Source Classification	Reference Standards Bacterial Parasite Apoptosis
beta-Mangostin (Standard) is the analytical standard of beta-Mangostin. This product is intended for research and analytical applications. beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic) .

HY-N8285

Sporogen AO-1	Natural Products Microorganisms Source Classification	Parasite
Sporogen AO-1 is a fungal metabolite originally isolated from the fungusAspergillus oryzae. Sporogen AO-1 has significant antimalarial activity againstplasmodium falciparum, with an IC₅₀ value of 1.53 μM, and also has certain cytotoxicity .

HY-N3283

6-Methylhydroxyangolensate	Khaya grandifoliola C. DC. Natural Products Plants Meliaceae Source Classification	Parasite
6-Methylhydroxyyangolensate is a limonoid can be extracted from Khaya grandifoliola. 6-Methylhydroxyyangolensate has low antimalarial activity in vitro, with an IC₅₀ of 21.59 μg/ml against P. falciparum (W2/Indochina clone) .

HY-120607

Chevalone C	Infection Triterpenes Microorganisms Classification of Application Fields Terpenoids Disease Research Fields Source Classification	Parasite
Chevalone C, a meroterpenoid fungal metabolite, shows antimalarial activity with IC₅₀ value of 25.00 μg/mL. Chevalone C has anti-proliferative activity on colon HCT116, liver HepG2 and melanoma A375 cancer cell lines .

HY-145379

Miaosporone A	Infection Quinones Structural Classification Monophenols Classification of Application Fields Anthraquinones Phenols Endogenous metabolite Disease Research Fields Source Classification	Parasite Endogenous Metabolite
Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC₅₀ values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells .

HY-N5018R

Nepodin (Standard) Musizin (Standard)	Rumex crispus Linn. Polygonaceae Phenols Polyphenols Rumex japonicus Houtt. Plants Source Classification	Reference Standards Parasite AMPK
Nepodin (Standard) is the analytical standard of Nepodin. This product is intended for research and analytical applications. Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus .Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK .Nepodin (Musizin) has antidiabetic and antimalarial activities.

HY-N8521

6-O-Methacrylate	Infection Natural Products other families Classification of Application Fields Plants Disease Research Fields Source Classification	TMV Parasite
6-O-Methacrylate, a trilobolide, is isolated from the leaves of Wedelia trilobata. 6-O-Methacrylate displays marked antimalarial activity, with IC₅₀ of 8.9 μg/mL against P. falciparum parasite. 6-O-Methacrylate also has anti-tobacco mosaic virus (TMV) activity .

HY-N12232

Carbazomycin D	Structural Classification Alkaloids Microorganisms Indole Alkaloids Source Classification	Parasite Bacterial
Carbazomycin D exhibits antituberculosis and antimalarial activities, that inhibits Plasmodium falciparum with an IC₅₀ > 10 μg/mL, inhibits Mycobacterium tuberculosis with MIC of 25 μg/mL. Carbazomycin D exhibits cytotoxicity in cell MCF-7, KB, NCI-H187 and Vero, with IC₅₀s of 21.3, 33.2, 12.9, and 34.3 μg/mL, respectively .

HY-N12230

Penicolinate B	Microorganisms Ketones, Aldehydes, Acids Source Classification	Bacterial Parasite Fungal
Penicolinate B is a picolinic acid derivative that can be isolated from Penicillium sp. Penicolinate B exhibits antimalarial activity (IC₅₀: 1.40 μg/mL), antitubercular activity (MIC: 25.0 μg/mL), activity against Bacillus cereus (IC₅₀: 25.0 μg/mL), and activity against Candida albicans (IC₅₀: 1.45 μg/mL). Penicolinate B also has certain cytotoxicity against cancer cells such as MCF-7, KB, and NCI-H187. Penicolinate B can be used in research on malaria, tuberculosis, bacterial/fungal infections and tumors .

HY-N8345

Isocudraniaxanthone B	Guttiferae Garcinia vieillardii Pierre Plants Source Classification	Others
Isocudraniaxanthone B (compound 10) is a kind of xanthone. Isocudraniaxanthone B can be isolated from Calophyllum caledonicum. Isocudraniaxanthone B has *antimalarial* activity with an IC50 value of 3.2 μg/mL .

HY-N1678

2,6-Dimethoxy-1-acetonylquinol	Malvaceae Ketones, Aldehydes, Acids Grewia bilamellata Plants Source Classification	Others
2,6-Dimethoxy-1-acetonylquinol (compound 6) can be isolated from Grewia bilamellata. 2,6-Dimethoxy-1-acetonylquinol has antimalarial activity .

Cat. No.	Product Name	Chemical Structure

HY-B0273S1

Sulfadiazine-13C6
Sulfadiazine- ¹³C₆ is a labeled Sulfadiazine (HY-B0273). Sulfadiazine is a sulfonamide?antibiotic with antimalarial activity[1].

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