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Cat. No.: HY-150065

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Antimalarial agent 15

Antimalarial agent 15 (Compound 4e) is a parasite inhibitor. Antimalarial agent 15 shows antimalarial activity, and can inhibit P. falciparum 3D7 parasite growth (IC₅₀=20 nM).

For research use only. We do not sell to patients.

CAS No.: 956928-33-9
Formula: C₂₉H₃₀N₂O₆
Molecular Weight:502.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Antimalarial agent 15 Chemical Structure

CAS No.: 956928-33-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Antimalarial agent 15 (Compound 4e) is a parasite inhibitor. Antimalarial agent 15 shows antimalarial activity, and can inhibit P. falciparum 3D7 parasite growth (IC₅₀=20 nM)^[1].

IC₅₀ & Target

IC50: 20 nM (P. falciparum 3D7)^[1]

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	>3000 nM Compound: 4e	Cytotoxicity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by Cell Count Reagent SF based assay Cytotoxicity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by Cell Count Reagent SF based assay	[PMID: 35594648]

In Vitro

Antimalarial agent 15 shows no cytotoxicity against mammalian cells or affects the growth of bacteria and fungi up to 30 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 956928-33-9
Molecular Weight 502.56
Formula C₂₉H₃₀N₂O₆
SMILES

CCCCC1=CC(OC2=C1C(OCC(N3CC4=C(C5=C(N4)C=CC=C5)C[C@H]3C(OC)=O)=O)=CC(C)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nobuo Cho, et al. New antimalarials identified by a cell-based phenotypic approach: Structure-activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety. Bioorg Med Chem. 2022 Jul 15;66:11683 [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

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100 mg

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