1. Anti-infection
    Antibody-drug Conjugate/ADC Related
  2. Bacterial
    ADC Cytotoxin
    Parasite
  3. Polyketomycin

Polyketomycin 

Cat. No.: HY-106338
Handling Instructions

Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities.

For research use only. We do not sell to patients.

Polyketomycin Chemical Structure

Polyketomycin Chemical Structure

CAS No. : 200625-47-4

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Description

Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities[1][2][3].

IC50 & Target[1][2]

Traditional Cytotoxic Agents

 

In Vitro

Polyketomycin exhibits growth inhibition against L1210 leukemia, EL-4 leukemia, P388 leukemia, Ehrlich carcinoma, IMC carcinoma, colon 26 adnocarcinoma, Meth A fibrosarcoma, FS-3 fibrosarcoma and B16-BL10 melanoma with IC50 values of 3.3 μg/mL, 2.1 μg/mL, 5.2 μg/mL, 1 μg/mL, 0.9 μg/mL, 1.8 μg/mL, 2.4 μg/mL, 1.5 μg/mL and 1.6 μg/mL, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The acute toxicity (LD50, ip) of Polyketomycin in mice is estimated to be 6.25-12.5mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

864.84

Formula

C₄₄H₄₈O₁₈

CAS No.

200625-47-4

SMILES

O[[email protected]]1([[email protected]@H]2O[[email protected]]3([H])O[[email protected]@H]([[email protected]@H](O[[email protected]@]4([H])C[[email protected]@](O)([[email protected]](OC(C5=C(C(C)=CC=C5C)O)=O)[[email protected]](C)O4)C)CC3)C)[[email protected]](C(C6=C(C(C)=C7C(C(C=C(OC)C7=O)=O)=C6O)C1)=O)(C(/C(C2=O)=C(O)\C)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PolyketomycinBacterialADC CytotoxinParasiteADCCytotoxinMRSAantibioticanticancertetracyclicquinoneglycosideantimalarialInhibitorinhibitorinhibit

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Polyketomycin
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