1. Anti-infection
    Antibody-drug Conjugate/ADC Related
  2. Bacterial
    ADC Cytotoxin
    Parasite
  3. Polyketomycin

Polyketomycin 

Cat. No.: HY-106338
Handling Instructions

Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities.

For research use only. We do not sell to patients.

Polyketomycin Chemical Structure

Polyketomycin Chemical Structure

CAS No. : 200625-47-4

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Description

Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities[1][2][3].

IC50 & Target[1][2]

Traditional Cytotoxic Agents

 

In Vitro

Polyketomycin exhibits growth inhibition against L1210 leukemia, EL-4 leukemia, P388 leukemia, Ehrlich carcinoma, IMC carcinoma, colon 26 adnocarcinoma, Meth A fibrosarcoma, FS-3 fibrosarcoma and B16-BL10 melanoma with IC50 values of 3.3 μg/mL, 2.1 μg/mL, 5.2 μg/mL, 1 μg/mL, 0.9 μg/mL, 1.8 μg/mL, 2.4 μg/mL, 1.5 μg/mL and 1.6 μg/mL, respectively[1].

In Vivo

The acute toxicity (LD50, ip) of Polyketomycin in mice is estimated to be 6.25-12.5mg/kg[1].

Molecular Weight

864.84

Formula

C₄₄H₄₈O₁₈

CAS No.

200625-47-4

SMILES

O[[email protected]]1([[email protected]@H]2O[[email protected]]3([H])O[[email protected]@H]([[email protected]@H](O[[email protected]@]4([H])C[[email protected]@](O)([[email protected]](OC(C5=C(C(C)=CC=C5C)O)=O)[[email protected]](C)O4)C)CC3)C)[[email protected]](C(C6=C(C(C)=C7C(C(C=C(OC)C7=O)=O)=C6O)C1)=O)(C(/C(C2=O)=C(O)\C)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PolyketomycinBacterialADC CytotoxinParasiteADCCytotoxinMRSAantibioticanticancertetracyclicquinoneglycosideantimalarialInhibitorinhibitorinhibit

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Polyketomycin
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