200625-47-4
Chemical Structure
Polyketomycin
- CAS 番号: 200625-47-4
- Formula:C44H48O18
- Molecular Weight:864.84
IUPAC Name: (2S,3R,4R,6S)-4-hydroxy-2,4-dimethyl-6-(((2R,3S,6S)-2-methyl-6-(((1S,4aS,12aR,E)-4a,6,12a-trihydroxy-3-(1-hydroxyethylidene)-9-methoxy-11-methyl-2,4,5,7,10-pentaoxo-1,2,3,4,4a,5,7,10,12,12a-decahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)tetrahydr
InChIKey: OWRCRVABZYJUES-FLJLGRLJSA-N
SMILES: O[C@]1([C@@H]2O[C@]3([H])O[C@@H]([C@@H](O[C@@]4([H])C[C@@](O)([C@H](OC(C5=C(C(C)=CC=C5C)O)=O)[C@H](C)O4)C)CC3)C)[C@](C(C6=C(C(C)=C7C(C(C=C(OC)C7=O)=O)=C6O)C1)=O)(C(/C(C2=O)=C(O)\C)=O)O
Biological Activity: Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities[1][2][3].
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Polyketomycin | Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities. | |||||||||||||||||||||
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References
- [1]. Momose I, et al. Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1998 Jan;51(1):21-5. [Content Brief]
- [2]. Daum M, et al. Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. Chembiochem. 2009 Apr 17;10(6):1073-83. [Content Brief]
- [3]. Otoguro K, In vitro antimalarial activities of the microbial metabolites. J Antibiot (Tokyo). 2003 Mar;56(3):322-4. [Content Brief]
