Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities

  • J Antibiot (Tokyo). 1998 Jan;51(1):21-5. doi: 10.7164/antibiotics.51.21.
I Momose  1 ,  W Chen ,  N Kinoshita ,  H Iinuma ,  M Hamada ,  T Takeuchi
Affiliations
  • 1. Institute of Microbial Chemistry, Tokyo, Japan.
PMID: 9531983 DOI: 10.7164/antibiotics.51.21
Abstract

A new Antibiotic designated polyketomycin was isolated from the culture broth of Streptomyces sp. MK277-AF1. It was purified by ethyl acetate extraction, Sephadex LH-20 column chromatography and centrifugal partition chromatography (CPC). It inhibited growth of Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA). Its MICs were less than 0.2 microgram/ml. Polyketomycin exhibited cytotoxic activity against nine tumor cell lines at concentrations of 0.9-5.2 micrograms/ml.

Products