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Cat. No.: HY-150066

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Antimalarial agent 16

Antimalarial agent 16 (Compound 4h) is a parasite inhibitor. Antimalarial agent 16 shows antimalarial activity, and can inhibit P. falciparum parasite growth (IC₅₀=2.0 nM).

For research use only. We do not sell to patients.

CAS No.: 2773408-33-4
Formula: C₃₀H₃₂N₂O₆
Molecular Weight:516.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Antimalarial agent 16 Chemical Structure

CAS No.: 2773408-33-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Antimalarial agent 16 (Compound 4h) is a parasite inhibitor. Antimalarial agent 16 shows antimalarial activity, and can inhibit P. falciparum parasite growth (IC₅₀=2.0 nM)^[1].

IC₅₀ & Target

IC50: 2.0 nM (P. falciparum)^[1]

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	>3000 nM Compound: 4h	Cytotoxicity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by Cell Count Reagent SF based assay Cytotoxicity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by Cell Count Reagent SF based assay	[PMID: 35594648]

In Vivo

Antimalarial agent 16 (i.p.; 40 or 200 mg/kg; once daily; 4 days) exhibits significant in vivo antimalarial effects^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Plasmodium berghei (P. berghei) ANKA infected ICR mouse^[1]
Dosage:

40 or 200 mg/kg
Administration:

Intraperitoneal injection; 40 or 200 mg/kg; once daily; 4 days
Result:

Inhibited malaria parasite growth effectively and retained parasitemia levels until day 8 post-infection at a dose of 40 mg/kg, attenuated parasitemia levels until day 8.
Maintained survival rates until day 11 post-infection, but the rates decreased rapidly after day 11 at a dose of 40 mg/kg, observed a significant enhancement in survival a dose of 200 mg/kg.

Chemical Information

CAS No. 2773408-33-4
Molecular Weight 516.58
Formula C₃₀H₃₂N₂O₆
SMILES

CCCCC1=CC(OC2=C1C(O[C@H](C)C(N3CC4=C(C5=C(N4)C=CC=C5)C[C@H]3C(OC)=O)=O)=CC(C)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nobuo Cho, et al. New antimalarials identified by a cell-based phenotypic approach: Structure-activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety. Bioorg Med Chem. 2022 Jul 15;66:11683 [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References

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Antimalarial agent 16

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Antimalarial agent 16 Related Classifications

HY-150066 Related Classifications