Search Result

Results for "

secretase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Beta-secretase (37) γ-secretase (97) Akt (2) Amyloid-β (41) Apoptosis (13) ATM/ATR (1) Autophagy (1) Biochemical Assay Reagents (2) Calcium Channel (3) Caspase (1) Cholecystokinin Receptor (1) Cholinesterase (ChE) (9) COX (1) Drug Derivative (1) Drug Isomer (1) Drug Metabolite (2) EGFR (2) Endogenous Metabolite (1) ERK (2) Ferroptosis (1) Fluorescent Dye (4) Fungal (1) GABA Receptor (3) HIF/HIF Prolyl-Hydroxylase (1) Interleukin Related (1) Isotope-Labeled Compounds (3) Liposome (1) MMP (1) mTOR (1) NF-κB (1) NO Synthase (1) Notch (16) Organoid (2) PACAP Receptor (2) Phosphatase (1) Phosphodiesterase (PDE) (4) Proteasome (2) PTEN (1) Reactive Oxygen Species (ROS) (2) Reference Standards (15) Sodium Channel (5) Src (1) VEGFR (1)
By Research Areas:	Cancer (31) Infection (3) Inflammation/Immunology (11) Metabolic Disease (6) Neurological Disease (128)
Click Chemistry:	Azide (1)
Oligonucleotides:	Cationic Lipids (1)

165

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

GMP Molecules

Targets Recommended: γ-secretase Beta-secretase Legumain

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14176

Compound E 15+ Cited Publications γ-secretase-IN-1	γ-secretase	Cancer
Compound E is a *γ-secretase* inhibitor. Compound E blocks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC₅₀s of 0.24, 0.37, 0.32 nM, respectively.

HY-13526

YO-01027 5+ Cited Publications Dibenzazepine; DBZ	Notch γ-secretase	Cancer
YO-01027 (Dibenzazepine;DBZ) is a potent *γ-secretase* inhibitor with IC₅₀ values of 2.92 and 2.64 nM for Notch and APPL cleavage, respectively.

HY-50752

LY-411575 25+ Cited Publications	Organoid γ-secretase Notch Apoptosis	Neurological Disease
LY-411575 is a potent *γ-secretase* inhibitor with IC₅₀ of 0.078 nM/0.082 nM (membrane/cell-based), and also inhibits Notch S3 cleavage with an IC₅₀ of 0.39 nM.

HY-11102

RO4929097 15+ Cited Publications	γ-secretase Notch	Neurological Disease Cancer
RO4929097 is an orally active γ secretase inhibitor with an IC₅₀ of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC₅₀ of 14 nM and 5 nM, respectively .

HY-15185

Nirogacestat 10+ Cited Publications PF-3084014	γ-secretase Apoptosis	Cancer
Nirogacestat (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective *γ-secretase* inhibitor with an IC₅₀ of 6.2 nM. Inhibition of Notch signaling by Nirogacestat while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers .

HY-18236

MDL-28170 15+ Cited Publications Calpain Inhibitor III	Proteasome	Neurological Disease Inflammation/Immunology
MDL-28170 (Calpain Inhibitor III) is a potent, selective and membrane-permeable cysteine protease inhibitor of calpain that rapidly penetrates the blood-brain barrier following systemic administration . MDL-28170 also block γ-secretase .

HY-12449

Crenigacestat 5+ Cited Publications LY3039478	Notch γ-secretase	Cancer
Crenigacestat (LY3039478) is an orally active Notch and *γ-secretase* inhibitor, with an IC₅₀ of 1 nM in most of the tumor cell lines tested .

HY-19369

L-685458 5+ Cited Publications L-685,458	γ-secretase Apoptosis	Neurological Disease Cancer
L-685458 is a potent transition state analog (TSA) *γ-secretase* inhibitor (GSI). L-685458 inhibits amyloid β-protein precursor γ-secretase activity with IC₅₀ of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits γ-secretase-mediated cleavage of APP-C99 and Notch-100 with IC₅₀s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimer’s disease (AD) and cancers .

HY-12465

Z-Ile-Leu-aldehyde 2 Publications Verification Z-IL-CHO; GSI-XII; γ-secretase inhibitor XII	Notch γ-secretase Apoptosis	Cancer
Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of *γ-secretase* and notch .

HY-159836

Nivegacetor RG6289	γ-secretase	Neurological Disease
Nivegacetor is a potent *γ-secretase* modulator .

HY-13027G

DAPT GSI-IX	γ-secretase	Neurological Disease Inflammation/Immunology Cancer
DAPT (GSI-IX) (GMP) is DAPT (HY-13027) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DAPT is a potent and orally active *γ-secretase* inhibitor .

HY-B1786

Sulindac sulfide 1 Publications Verification cis-Sulindac sulfide	Drug Metabolite γ-secretase	Neurological Disease
Sulindac sulfide is a noncompetitive *γ-secretase* inhibitor, with an IC₅₀ of 20.2 μM for γ₄₂-secretase activity.

HY-B0703

Eslicarbazepine acetate BIA 2-093	Beta-secretase Sodium Channel	Neurological Disease
Eslicarbazepine acetate (BIA 2-093), an antiepileptic agent, is a dual a dual Inhibitor of *β-Secretase* and voltage-gated sodium channel.

HY-15670

BMS-906024 3 Publications Verification	γ-secretase Notch	Cancer
BMS-906024 is an orally active and selective γ-secretase (gamma secretase) inhibitor. BMS-906024 is a potent pan-Notch receptors inhibitor with IC₅₀s of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity .

HY-50883

BMS 299897	γ-secretase	Neurological Disease
BMS 299897 is a sulfonamide *γ-secretase* inhibitor with an IC₅₀ of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).

HY-124832

*δ-Secretase* inhibitor 11** 1 Publications Verification	Caspase Amyloid-β	Neurological Disease
δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific *δ-secretase* inhibitor, with an IC₅₀ of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research .

HY-N2319

Dihydroergocristine mesylate 1 Publications Verification DHEC mesylate	Amyloid-β	Neurological Disease
Dihydroergocristine mesylate (DHEC mesylate) is a inhibitor of γ-secretase (GSI), reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (K_d) of 25.7 nM and 9.8 μM, respectively .

HY-76562

Methyl 6-bromopicolinate	Biochemical Assay Reagents	Others
Methyl 6-bromopicolinate is a synthetic intermediate used in the preparation of *γ-secretase* inhibitor library scaffolds .

HY-14175

Begacestat GSI-953	γ-secretase	Neurological Disease
Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein *gamma-secretase* (IC₅₀Aβ₄₀=15 nM) for the treatment of Alzheimer's disease .

HY-10043

*gamma-secretase* modulator 1**	γ-secretase	Neurological Disease
γ-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease.

HY-P1962

*β-Secretase* inhibitor** [Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)	Beta-secretase	Neurological Disease
β-Secretase inhibitor ([Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)) is a *β-secretase* and BACE1 inhibitor (IC₅₀: 25 nM for β-secretase) .

HY-10133

*β-Secretase* Inhibitor IV**	Beta-secretase	Neurological Disease
β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC₅₀s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.

HY-108714

NGP555	γ-secretase	Neurological Disease
NGP555 is a *γ-secretase* modulator. NGP555 Lowers the Amyloid Biomarker Aβ42 .

HY-N2215

Aloeresin D	Beta-secretase	Neurological Disease
Aloeresin D is a chromone glycoside isolated from Aloe vera, inhibits β-Secretase (BACE1) activity, with an IC₅₀ of 39 μM .

HY-119165

GSM-1	γ-secretase	Neurological Disease
GSM-1 is a potent *γ-secretase* modulator. GSM-1 directly targets the transmembrane domain (TMD) 1 of presenilin 1 (PS1) .

HY-171347

*gamma-secretase* modulator 6**	γ-secretase Amyloid-β	Neurological Disease
gamma-secretase modulator 6 (Example 50) is a *gamma-secretase* modulator. gamma-secretase modulator 6 inhibits Aβ42 secretion in HEK cell line stably expressing APP (Aβ amyloid precursor protein) (pIC₅₀: 8.1). gamma-secretase modulator 6 can be used for research of Alzheimer's disease .

HY-145343

RO7185876	γ-secretase	Neurological Disease
RO7185876 is a potent and selective gamma secretase modulator as a potential research for Alzheimer's disease.

HY-136674

Aftin-5	Amyloid-β	Neurological Disease
Aftin-5 is an inducer for Amyloid-β 42 (Aβ42). Aftin-5 upregulates Aβ42 and downregulates Aβ38 levels in a β-secretase- and γ-secretase-dependent manner by altering the ultrastructure of mitochondria. Aftin-5 exhibits slightly cytotoxicity in cell SH-SY5Y, HT22, N2a and N2a-AβPP695, with IC₅₀s of 180, 194, 178 and 150 μM, respectively .

HY-16632

ELND 006	γ-secretase Amyloid-β	Metabolic Disease
ELND 006 (Compound 30) is a metabolically stable γ-secretase inhibitor designed to selectively inhibit amyloid beta (Aβ) generation while sparing Notch signaling. It was developed through a synthetic strategy emphasizing diversity and chirality. ELND 006, along with its analog ELND007 (Compound 34), progressed into human clinical trials. In preclinical studies, both compounds demonstrated effective reduction of Aβ levels in vitro and in vivo. Comparisons with other γ-secretase inhibitors like Semagacestat, Begacestat, and Avagacestat underscored their potency and specificity in lowering Aβ levels in cerebrospinal fluid (CSF) of healthy human volunteers, suggesting potential therapeutic efficacy in Alzheimer's disease .

HY-150049

*γ-Secretase* modulator 13**	Amyloid-β	Neurological Disease
γ-Secretase modulator 13 (compound 4) is a gamma-secretase modulator (GSMs) that inhibits the production of the aggregated amyloid β-peptide Aβ42 with an IC₅₀ value of 163 nM. γ-Secretase modulator 13 can be used in the study of Alzheimer's disease .

HY-50882

ELN318463	γ-secretase	Neurological Disease
ELN318463 is an amyloid precursor protein (APP) selective *γ-secretase* inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC₅₀s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN318463 is 51-fold more selective for PS1 .

HY-15211

MRK 003	γ-secretase Apoptosis	Neurological Disease Cancer
MRK 003 is a potent, selective and orally active *γ-secretase* inhibitor. MRK 003 reduce brain Aβ production in vivo. MRK 003 induces caspase-dependent apoptosis and inhibits tumor cell proliferation in vivo and in vitro .

HY-158012

LY3056480	γ-secretase	Others
LY3056480 is a gamma-secretase inhibitor (GSI) that inhibits Notch signaling. LY3056480 improves mild to moderate sensorineural hearing loss and is safe and tolerable. Intratympanic administration of LY3056480 induces hair cell regeneration and partial hearing recovery in mammals .

HY-171444

GSM III	γ-secretase Amyloid-β	Neurological Disease
GSM III is a *γ-Secretase* complexe (GSEC) modulator. GSM III significantly regulates amyloid-β (Aβ)** length at the extracellular interface between the protease (NCT, PSEN) and the substrate APP_C99. GSM III can be used for Alzheimer's disease (AD) research .

HY-14176G

Compound E γ-secretase-IN-1	γ-secretase	Cancer
Compound E (GMP) is a GMP-grade Compound E (HY-14176). GMP-grade small molecules can be used as adjuvant reagents in cell therapy. Compound E is a *γ-secretase* inhibitor. Compound E inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC₅₀ values of 0.24, 0.37, and 0.32 nM, respectively .

HY-115726

FRM-024	γ-secretase Amyloid-β	Neurological Disease
FRM-024 is a central nervous system-penetrant, orally active *γ-secretase* modulator and Aβ42 lowering agent. FRM-024 is used for the research of familial Alzheimer's disease .

HY-P4428

Z-Val-Lys-Met-AMC	Fluorescent Dye	Others
Z-Val-Lys-Met-AMC is a fluorescent substrate that can be used to detect the β-secretase activity of cathepsin B .

HY-14176A

(1R,3S)-Compound E	γ-secretase	Cancer
(1R,3S)-Compound E is the isomer of Compound E (HY-14176), and can be used as an experimental control. Compound E is a *γ-secretase* inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC₅₀s of 0.24, 0.37, 0.32 nM, respectively.

HY-171349

Amyloid-β-IN-3	γ-secretase Amyloid-β	Neurological Disease
Amyloid-β-IN-3 (EX.113) is a selective *γ-secretase* inhibitor. Amyloid-β-IN-3 inhibits Aβ42 secretion in H4 cells with an EC₅₀ value of 148 nM. Amyloid-β-IN-3 regulates the γ-secretase catalytic activity to decrease Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. Amyloid-β-IN-3 is promising for research of Alzheimer's disease (AD) .

HY-109174

Fosciclopirox CPX-POM	γ-secretase	Metabolic Disease Cancer
Fosciclopirox (CPX-POM) suppresses growth of urothelial cancer by targeting the *γ-secretase* complex. Fosciclopirox selectively delivers the active metabolite, Ciclopirox (CPX), to the entire urinary tract. Ciclopirox has anticancer activity in a number of solid and hematologic malignancies .

HY-50900

*gamma-Secretase* Modulators** Amyloid-β production inhibitor; γ-secretase Modulators	Amyloid-β	Neurological Disease
gamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor.

HY-164451

GSI-18	γ-secretase Notch	Cancer
GSI-18 is a γ-secretase inhibitor with anticancer activity. GSI-18 inhibits the attachment-free growth of pancreatic cancer cells by inhibiting Notch signaling .

HY-P10077

GL189	Beta-secretase	Neurological Disease
GL189 is a *β-secretase* inhibitor. GL189 has neuroprotective effect, and can be used for research of neurodegenerative diseases .

HY-P4428A

Z-Val-Lys-Met-AMC TFA	Fluorescent Dye	Others
Z-Val-Lys-Met-AMC TFA is a fluorescent substrate that can be used to detect the β-secretase activity of cathepsin B .

HY-50882A

ELN318463 racemate	γ-secretase	Neurological Disease
ELN318463 racemate is the racemate of ELN318463. ELN318463 is an amyloid precursor protein (APP) selective *γ-secretase* inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC₅₀s of 12nM and 656 nM for PS1and PS2, respectively. ELN318463 is 51-fold more selective for PS1 .

HY-N8890

Demissidine	Beta-secretase γ-secretase	Others
Demissidine is an alkaloid that can be isolated from potato . Demissidine is a promising dual inhibitors against β- and γ-secretase proteins in silico .

HY-P4926

Mca-SEVKMDAEFRK(Dnp)RR-NH2	Amyloid-β	Neurological Disease
Mca-SEVKMDAEFRK(Dnp)RR-NH2, containing the wild-type amyloid precursor protein (APP) beta-secretase cleavage site, is the substrate of thimet oligopeptidase (TOP). It is used for Alzheimer's disease research .

HY-103538

JLK-6	Amyloid-β	Neurological Disease
JLK-6 markedly reduce the production of amyloid β-peptide (Aβ) by amyloid-β Precursor protein (APP) expressing HEK293 cells by affecting the γ-secretase cleavage of APP, with no effect on the cleavage of the Notch receptor .

HY-117957

BMS-932481	γ-secretase	Neurological Disease
BMS-932481 is an orally active modulator for *γ-secretase, selectively reduce Aβ1-42 and Aβ1-40 production, with IC₅₀*s of 6.6 and 25.3 nM, respectively .

HY-P10189

*α-Secretase* Substrate, Fluorogenic**	Biochemical Assay Reagents	Others
α-Secretase Substrate, Fluorogenic is α-secretase fluorogenic substrate that can be used to test α-secretase activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0702

Tenuifolin	Triterpenes Terpenoids Polygalaceae Plants Polygala tenuifolia Willd. Source Classification	Beta-secretase Cholinesterase (ChE)
Tenuifolin is effective and has a protective action. Tenuifolin inhibits *β-secretase* decreases Aβ protein secretion, suppresses Aβ25-35 secretion, and subsequently caspase-3 and caspase-9 become active. Tenuifolin's ability to lower AChE activity, increase at the same time, increase the ability of the upper glands, and improve the ability to read and remember. Research on tenuifolin's potential for use in urinary disease (AD).

HY-N1860

3-O-Methylquercetin	Flavonoids Classification of Application Fields Flavones Aconitum apetalum (Huth) B. Fedtsch. Plants Rhamnaceae Inflammation/Immunology Disease Research Fields	Phosphodiesterase (PDE) NO Synthase
3-O-Methylquercetin is an inhibitor of cAMP and CGMP-phosphodiesterase (PDE) with IC₅₀ at 13.8 μM and 14.3 μM, respectively. 3-O-Methylquercetin is an inhibitor of β-secretase with an IC₅₀ of 6.5 μM. 3-O-Methylquercetin has a neuroprotective effect against neuronal death caused by oxidative damage. 3-O-Methylquercetin has strong antiviral activity against poliovirus, coxsackie virus and human rhinovirus. 3-O-Methylquercetin has anti-inflammatory and trachea-relaxing effects and can be used in the study of inflammatory diseases and asthma .

HY-N2215

Aloeresin D	Monophenols Liliaceae Simple Phenylpropanols Phenols Aloe vera (L.) Burm. f. Phenylpropanoids Plants Source Classification	Beta-secretase
Aloeresin D is a chromone glycoside isolated from Aloe vera, inhibits β-Secretase (BACE1) activity, with an IC₅₀ of 39 μM .

HY-N1280

Semilicoisoflavone B	Flavonoids Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Isoflavones Source Classification	Amyloid-β
Semilicoisoflavone B, an isoflavone, mainly derived from Glycyrrhiza uralensis Fisch.. Semilicoisoflavone B reduces amyloid β (Aβ) secretion by inhibiting β-secretase-1 (BACE1) expression and activity. Semilicoisoflavone B decreases BACE1 expression mainly through increasing PPARγ expression and inhibiting STAT3 phosphorylation .

HY-N11709

Theasaponin E1	Triterpenes Structural Classification Terpenoids Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Apoptosis VEGFR ATM/ATR PTEN Akt mTOR HIF/HIF Prolyl-Hydroxylase NF-κB Notch Cholinesterase (ChE) Amyloid-β γ-secretase Ferroptosis Fungal
Theasaponin E1 is an orally effective tea saponin. Theasaponin E1 inhibits the proliferation of cancer cells by activating apoptosis. Theasaponin E1 inhibits angiogenesis in ovarian cancer cells and HUVECs by reducing the expression of VEGF. Theasaponin E1 upregulates the phosphorylation level of ATM protein and the expression level of PTEN protein in cancer cells, decreases the phosphorylation levels of Akt, mTOR, p70S6K and 4E-BP1 proteins, downregulates the expression of HIF-1α and NF-κB, and reduces the protein expression of Notch ligands Dll4 and Jagged1. Theasaponin E1 exerts neuroprotective effects by inhibiting the activity of acetylcholinesterase, activating *α-secretase* and neprilysin, reducing the concentration of Aβ, and inhibiting the activities of *β-secretase* and *γ-secretase. Theasaponin E1 exhibits toxic effects on cancer cells and quinone reductase-inducing activity, and inhibits tumor growth in vivo. Theasaponin E1 induces ferroptosis* in Pomacea canaliculata by synergistically disrupting cholesterol homeostasis and sphingolipid metabolism. Theasaponin E1 possesses anti-biofilm activity against Candida albicans. Theasaponin E1 can be used in the research of ovarian cancer, obesity, Alzheimer's disease and fungal infections .

HY-N3734

Deoxyneocryptotanshinone	Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	Beta-secretase Phosphatase
Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity BACE1 (Beta-secretase) inhibitor with an IC₅₀ value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research .

HY-N8890

Demissidine	Structural Classification Alkaloids Steroid Alkaloids Solanum tuberosum L. Solanaceae Plants Source Classification	Beta-secretase γ-secretase
Demissidine is an alkaloid that can be isolated from potato . Demissidine is a promising dual inhibitors against β- and γ-secretase proteins in silico .

HY-129133

cis-Miyabenol C	Vitis vinifera cv. Zalema Phenols Plants Vitaceae Source Classification	Drug Isomer
cis-Miyabenol C is an isomer of the resveratrol trimer Miyabenol C, which can be isolated from grape herbs. Miyabenol C is an inhibitor of β-amyloid (Aβ) and amyloid β precursor protein (APP) in Alzheimer's disease model mice, and inhibit *β-secretase* activity without changing the protein level of β-secretase BACE1 .

HY-101017R

Palmitoylcarnitine chloride (Standard)	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Akt Calcium Channel
Eslicarbazepine acetate (Standard) is the analytical standard of Eslicarbazepine acetate. This product is intended for research and analytical applications. Eslicarbazepine acetate (BIA 2-093), an antiepileptic agent, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.

HY-N2215R

Aloeresin D (Standard)	Structural Classification Monophenols Liliaceae Simple Phenylpropanols Phenols Aloe vera (L.) Burm. f. Phenylpropanoids Plants Source Classification	Reference Standards Beta-secretase
Aloeresin D (Standard) is the analytical standard of Aloeresin D. This product is intended for research and analytical applications. Aloeresin D is a chromone glycoside isolated from Aloe vera, inhibits β-Secretase (BACE1) activity, with an IC₅₀ of 39 μM .

HY-N0702R

Tenuifolin (Standard)	Triterpenes Structural Classification Terpenoids Polygalaceae Plants Polygala tenuifolia Willd. Source Classification	Reference Standards Beta-secretase Cholinesterase (ChE)
Tenuifolin (Standard) is the analytical standard of Tenuifolin. This product is intended for research and analytical applications. Tenuifolin is effective and has a protective action. Tenuifolin inhibits β-secretase decreases Aβ protein secretion, suppresses Aβ25-35 secretion, and subsequently caspase-3 and caspase-9 become active. Tenuifolin's ability to lower AChE activity, increase at the same time, increase the ability of the upper glands, and improve the ability to read and remember. Research on tenuifolin's potential for use in urinary disease (AD) .

Cat. No.	Product Name	Chemical Structure

HY-B1786S

Sulindac sulfide-d3
Sulindac sulfide-d₃ is deuterium labeled Sulindac sulfide. Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity.

HY-B0703S

Eslicarbazepine acetate-d4
Eslicarbazepine acetate-d₄ is deuterated labeled Eslicarbazepine acetate (HY-B0703). Eslicarbazepine acetate (BIA 2-093), an antiepileptic agent, is a dual a dual Inhibitor of *β-Secretase* and voltage-gated sodium channel.

HY-W744263

Eslicarbazepine Acetate-d3
Eslicarbazepine Acetate-d₃ is the deuterium labeled Eslicarbazepine acetate (HY-B0703). Eslicarbazepine acetate (BIA 2-093), an antiepileptic agent, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.

Targets Recommended: γ-secretase Beta-secretase Legumain

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14176G

Compound E γ-secretase-IN-1	γ-secretase	Cancer
Compound E (GMP) is a GMP-grade Compound E (HY-14176). GMP-grade small molecules can be used as adjuvant reagents in cell therapy. Compound E is a *γ-secretase* inhibitor. Compound E inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC₅₀ values of 0.24, 0.37, and 0.32 nM, respectively .

HY-13027G

DAPT GSI-IX	γ-secretase	Neurological Disease Inflammation/Immunology Cancer
DAPT (GSI-IX) (GMP) is DAPT (HY-13027) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DAPT is a potent and orally active *γ-secretase* inhibitor .

HY-13526G

YO-01027 Dibenzazepine; DBZ	Notch γ-secretase	Cancer
YO-01027 (Dibenzazepine) (GMP) is YO-01027 (HY-13526) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. YO-01027 is a potent *γ-secretase* inhibitor .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Species:	Human (6) Mouse (2)
Tag:	SUMO (1) His (5) Tag Free (1) Fc (2)
Source:	HEK293 (7) E. coli Cell-free (1)


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (1) Rabbit (2)
Reactivity:	Human (3) Bovine (1) Rat (3) Mouse (2) Dog (1) Pig (1)
Application:	IHC-P (1) ICC/IF (1) IP (2) WB (3) ELISA (1)
Isotype:	IgG (1) IgG/Kappa (1)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (3) Recombinant (1)
Modification:	Unmodified (3)


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

secretase

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

GMP Molecules

Natural
Products