1. Neuronal Signaling
    Stem Cell/Wnt
  2. γ-secretase
  3. L-685458

L-685458 (Synonyms: L-685,458)

Cat. No.: HY-19369 Purity: 99.78%
Handling Instructions

L-685458 is a potent inhibitor of Amyloid β-Protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested.

For research use only. We do not sell to patients.

L-685458 Chemical Structure

L-685458 Chemical Structure

CAS No. : 292632-98-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 782 In-stock
Estimated Time of Arrival: December 31
1 mg USD 168 In-stock
Estimated Time of Arrival: December 31
5 mg USD 528 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1008 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

    L-685458 purchased from MCE. Usage Cited in: Evid Based Complement Alternat Med. 2018 Nov 21;2018:3082507.

    Protein extracts are immunoblotted to determine the relative expression levels of VEGFR2, Notch1, Jagged1, and Hes1 in the treatment of Ox-LDL, TMP, PF, L-6854598.
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    Description

    L-685458 is a potent inhibitor of Amyloid β-Protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. IC50 value: 17 nM Target: γ-secretase in vitro: L-685458 is a Notch inhibitor. L-685458 blocks Notch activation in the two cell lines in terms of reduced cytoplasmic distribution and almost diminished nuclear labelling of Hes1 proteins. [2] L-685458 is a γ-secretase inhibitor. [3]

    Molecular Weight

    672.85

    Formula

    C₃₉H₅₂N₄O₆

    CAS No.

    292632-98-5

    SMILES

    O=C(N)[[email protected]](CC1=CC=CC=C1)NC([[email protected]](CC(C)C)NC([[email protected]](CC2=CC=CC=C2)C[[email protected]@H](O)[[email protected]@H](NC(OC(C)(C)C)=O)CC3=CC=CC=C3)=O)=O

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 31 mg/mL (46.07 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.4862 mL 7.4311 mL 14.8622 mL
    5 mM 0.2972 mL 1.4862 mL 2.9724 mL
    10 mM 0.1486 mL 0.7431 mL 1.4862 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References

    Purity: 99.78%

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    Product Name:
    L-685458
    Cat. No.:
    HY-19369
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