2. Neuronal Signaling
  3. Amyloid-β
  4. gamma-Secretase Modulators

gamma-Secretase Modulators  (Synonyms: Amyloid-β production inhibitor; γ-Secretase Modulators)

Cat. No.: HY-50900 Purity: 99.66%
COA Handling Instructions

gamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor.

For research use only. We do not sell to patients.

gamma-Secretase Modulators Chemical Structure

gamma-Secretase Modulators Chemical Structure

CAS No. : 937812-80-1

Size Price Stock Quantity
5 mg USD 604 In-stock
10 mg USD 1171 In-stock
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Description

gamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor. gamma-Secretase Modulators is useful for Alzheimer's disease. IC50 value: Target: γ-secretase modulator

Molecular Weight

483.48

Appearance

Solid

Formula

C26H24F3N3O3
CAS No.
SMILES

O=C1N2[[email protected]@H](COC[[email protected]]2([H])CC/C1=C\C3=CC(OC)=C(C=C3)N4C=NC(C)=C4)C5=CC(F)=C(F)C(F)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (206.83 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0683 mL 10.3417 mL 20.6834 mL
5 mM 0.4137 mL 2.0683 mL 4.1367 mL
10 mM 0.2068 mL 1.0342 mL 2.0683 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.17 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.17 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.17 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

gamma-Secretase Modulators937812-80-1Amyloid-β production inhibitor γ-Secretase ModulatorsAmyloid-ββ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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