1. Neuronal Signaling
  2. Amyloid-β
  3. gamma-Secretase Modulators

gamma-Secretase Modulators (Synonyms: Amyloid-β production inhibitor; γ-Secretase Modulators)

Cat. No.: HY-50900 Purity: 99.66%
Handling Instructions

gamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor. gamma-Secretase Modulators is useful for Alzheimer's disease.

For research use only. We do not sell to patients.

gamma-Secretase Modulators Chemical Structure

gamma-Secretase Modulators Chemical Structure

CAS No. : 937812-80-1

Size Price Stock Quantity
5 mg USD 604 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1171 In-stock
Estimated Time of Arrival: December 31
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Description

gamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor. gamma-Secretase Modulators is useful for Alzheimer's disease. IC50 value: Target: γ-secretase modulator

Molecular Weight

483.48

Formula

C₂₆H₂₄F₃N₃O₃

CAS No.

937812-80-1

SMILES

O=C1N2[[email protected]@H](COC[[email protected]]2([H])CC/C1=C\C3=CC(OC)=C(C=C3)N4C=NC(C)=C4)C5=CC(F)=C(F)C(F)=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (206.83 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0683 mL 10.3417 mL 20.6834 mL
5 mM 0.4137 mL 2.0683 mL 4.1367 mL
10 mM 0.2068 mL 1.0342 mL 2.0683 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.17 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.17 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.17 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.66%

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  • Molarity Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

gamma-Secretase ModulatorsAmyloid-β production inhibitor γ-Secretase ModulatorsAmyloid-ββ-amyloid peptideAbetaInhibitorinhibitorinhibit

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Product name:
gamma-Secretase Modulators
Cat. No.:
HY-50900
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