3,5-Bis(4-nitrophenoxy)benzoic acid
Based on 1 Customer Validation
3,5-Bis(4-nitrophenoxy)benzoic acid is an inhibitor of γ-secretase. 3,5-Bis(4-nitrophenoxy)benzoic acid causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25). 3,5-Bis(4-nitrophenoxy)benzoic acid, as a marker for fetal hypothyroidism, is a 3,3’-diiodothyronine sulfate (T2S) cross-reactive material in maternal serum.
For research use only. We do not sell to patients.
- Purity: 98.50%
- CAS No.: 173550-33-9
- Formula: C19H12N2O8
- Molecular Weight:396.31
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 173550-33-9
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Appearance Solid
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Molecular Weight 396.31
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Formula C19H12N2O8
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Color Light yellow to light brown
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SMILES
O=C(O)C1=CC(OC2=CC=C([N+]([O-])=O)C=C2)=CC(OC3=CC=C([N+]([O-])=O)C=C3)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (252.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Wu SY, et al. Compound W, a 3,3'-diiodothyronine sulfate cross-reactive substance in serum from pregnant women--a potential marker for fetal thyroid function. Pediatr Res. 2007;61(3):307-312. [Content Brief]
[2]. Ran Y, et al. Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors. PLoS One. 2015;10(6):e0128619. Published 2015 Jun 5. [Content Brief]
[3]. Greife A, et al. Canonical Notch signalling is inactive in urothelial carcinoma. BMC Cancer. 2014;14:628. Published 2014 Aug 29. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.5233 mL | 12.6164 mL | 25.2328 mL | 63.0819 mL |
| 5 mM | 0.5047 mL | 2.5233 mL | 5.0466 mL | 12.6164 mL | |
| 10 mM | 0.2523 mL | 1.2616 mL | 2.5233 mL | 6.3082 mL | |
| 15 mM | 0.1682 mL | 0.8411 mL | 1.6822 mL | 4.2055 mL | |
| 20 mM | 0.1262 mL | 0.6308 mL | 1.2616 mL | 3.1541 mL | |
| 25 mM | 0.1009 mL | 0.5047 mL | 1.0093 mL | 2.5233 mL | |
| 30 mM | 0.0841 mL | 0.4205 mL | 0.8411 mL | 2.1027 mL | |
| 40 mM | 0.0631 mL | 0.3154 mL | 0.6308 mL | 1.5770 mL | |
| 50 mM | 0.0505 mL | 0.2523 mL | 0.5047 mL | 1.2616 mL | |
| 60 mM | 0.0421 mL | 0.2103 mL | 0.4205 mL | 1.0514 mL | |
| 80 mM | 0.0315 mL | 0.1577 mL | 0.3154 mL | 0.7885 mL | |
| 100 mM | 0.0252 mL | 0.1262 mL | 0.2523 mL | 0.6308 mL |
3,5-Bis(4-nitrophenoxy)benzoic acid Related Classifications
HY-103539 Related Classifications
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