1. Neuronal Signaling
    Stem Cell/Wnt
  2. γ-secretase

Compound E (Synonyms: Compound E (secretase inhibitor);DuPont E)

Cat. No.: HY-14176 Purity: 99.87%
Handling Instructions

Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.

For research use only. We do not sell to patients.

Compound E Chemical Structure

Compound E Chemical Structure

CAS No. : 209986-17-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 561 In-stock
Estimated Time of Arrival: December 31
1 mg USD 160 In-stock
Estimated Time of Arrival: December 31
5 mg USD 520 In-stock
Estimated Time of Arrival: December 31
10 mg USD 920 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1900 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.

IC50 & Target

IC50: 0.24 nM (β-amyloid(40)), 0.37 nM (β-amyloid(42)), 0.24 nM (Notch)[1]

In Vitro

Compound E reduces the proliferation of T47D, and MCF-7 cell lines by less than 50% at a concentration of 50 μM[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0387 mL 10.1937 mL 20.3874 mL
5 mM 0.4077 mL 2.0387 mL 4.0775 mL
10 mM 0.2039 mL 1.0194 mL 2.0387 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

The breast cancer cell lines MDA-MB-231, T47D, and MCF-7 are treated with Compound E at concentrations in the range 0.01-50 μM for 48 h and their viability is determined using a Coulter counter[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

490.50

Formula

C₂₇H₂₄F₂N₄O₃

CAS No.

209986-17-4

SMILES

FC1=CC(CC(N[[email protected]@H](C)C(N[[email protected]@H]2C(N(C)C(C=CC=C3)=C3C(C4=CC=CC=C4)=N2)=O)=O)=O)=CC(F)=C1

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Compound E
Cat. No.:
HY-14176
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Compound E

Cat. No.: HY-14176