1. Neuronal Signaling
    Stem Cell/Wnt
  2. γ-secretase
  3. MK-0752

MK-0752 

Cat. No.: HY-10974 Purity: 98.76%
COA Handling Instructions

MK-0752 is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS Aβ in vivo.

For research use only. We do not sell to patients.

MK-0752 Chemical Structure

MK-0752 Chemical Structure

CAS No. : 471905-41-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 288 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 288 In-stock
Solid
5 mg USD 262 In-stock
10 mg USD 342 In-stock
50 mg USD 897 In-stock
100 mg USD 1357 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 10 publication(s) in Google Scholar

Top Publications Citing Use of Products

    MK-0752 purchased from MCE. Usage Cited in: Andrologia. 2019 Nov;51(10):e13413.  [Abstract]

    MK-0752 regulated the expression of cell proliferation-related genes at the mRNA and protein levels. The relative protein expression of p27 and p21Waf1/Cip1 in TM3 Leydig cells after treatment with 25 μM MK-0752 respectively. The representative Western blots for p27 and p21Waf1/Cip1 after treatment with MK-0752.

    MK-0752 purchased from MCE. Usage Cited in: EMBO Mol Med. 2017 Jul;9(7):950-966.  [Abstract]

    Turnover of endogenous CD74 P8 is inhibited by RO4929079 and BMS-906024. Cell lysate Western blot of A20 cells treated with GSIs is developed with In-1 antibody. MK-0752 and Semagacestat tests used the same control lane (0 nM).
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    MK-0752 is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS Aβ in vivo[1][2].

    In Vivo

    MK-0752 (60-240 mg/kg; p.o.) decreases the generation of newly produced Aβ in the brain of rhesus monkeys[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male rhesus monkeys[1]
    Dosage: 60-240 mg/kg
    Administration: P.o.
    Result: Generation of new Aβ was partially blocked with administration of 60 mg/kg, and nearly completely blocked at the 240 mg/kg dose as indicated by the dose-dependent decrease in the amount of 13C6-leucine-labeled Aβ.
    Clinical Trial
    Molecular Weight

    442.90

    Appearance

    Solid

    Formula

    C21H21ClF2O4S

    CAS No.
    SMILES

    O=S([[email protected]@]1(C2=C(C=CC(F)=C2)F)CC[[email protected]@H](CCC(O)=O)CC1)(C3=CC=C(Cl)C=C3)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (225.78 mM)

    Ethanol : 10 mg/mL (22.58 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2578 mL 11.2892 mL 22.5785 mL
    5 mM 0.4516 mL 2.2578 mL 4.5157 mL
    10 mM 0.2258 mL 1.1289 mL 2.2578 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.64 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.64 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.64 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 98.76%

    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    MK-0752
    Cat. No.:
    HY-10974
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