Amyloid 17-42
Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway.
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- CAS. Nr.: 155178-13-5
- Formel: C119H194N28O33S
- Molecular Weight:2577.05
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
In Vitro
Amyloid 17-42 (20 μM; 48 h) leads to apoptosis in SH-SY5Y and IMR-32 cells[1].
Amyloid 17-42 (20 μM; 48 h, 72 h) activates caspase-8 and caspase-3, induced poly(ADP-ribose) polymerase cleavage[1].
Amyloid 17-42 (20 μM) moderately activates c-Jun N-terminal kinase (JNK)[1].
Amyloid 17-42 induces neuronal apoptosis via a Fas-like/caspase-8 activation pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y and IMR-32 cells
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Concentration:0-30 μM
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Incubation Time:48 h
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Result:Caused the death of SH-SY5Y and IMR-32 human neuroblastoma cells.
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Cell Line:SH-SY5Y cells
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Concentration:20 μM
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Incubation Time:48 h
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Result:Showed shrunken cell bodies, condensed and fragmented chromatin, and increased amounts of cytoplasmic oligonucleosomes.
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Cell Line:SH-SY5Y cells
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Concentration:20 μM
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Incubation Time:48, 72 h; 18 h, 24 h
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Result:Reduced procaspase-3 and increased cleaved caspase-3 in cells.
Reduced procaspase-8 in cells.
Lead to early activation of JNK.
Chemical Information
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CAS. Nr. 155178-13-5
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Molecular Weight 2577.05
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Formel C119H194N28O33S
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Synonyms
Aβ(17-42)
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Sequence Shortening
LVFFAEDVGSNKGAIIGLMVGGVVIA
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Amyloid 17-42 Related Classifications
HY-P3779 Related Classifications
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