2. Apoptosis
  3. Apoptosis
  4. Amyloid 17-42

Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway.

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Amyloid 17-42 Chemical Structure

Amyloid 17-42 Chemical Structure

CAS No. : 155178-13-5

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Amyloid 17-42 Related Antibodies

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Description

Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway[1].

In Vitro

Amyloid 17-42 (20 μM; 48 h) leads to apoptosis in SH-SY5Y and IMR-32 cells[1].
Amyloid 17-42 (20 μM; 48 h, 72 h) activates caspase-8 and caspase-3, induced poly(ADP-ribose) polymerase cleavage[1].
Amyloid 17-42 (20 μM) moderately activates c-Jun N-terminal kinase (JNK)[1].
Amyloid 17-42 induces neuronal apoptosis via a Fas-like/caspase-8 activation pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amyloid 17-42 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: SH-SY5Y and IMR-32 cells
Concentration: 0-30 μM
Incubation Time: 48 h
Result: Caused the death of SH-SY5Y and IMR-32 human neuroblastoma cells.

Apoptosis Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 20 μM
Incubation Time: 48 h
Result: Showed shrunken cell bodies, condensed and fragmented chromatin, and increased amounts of cytoplasmic oligonucleosomes.

Western Blot Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 20 μM
Incubation Time: 48, 72 h; 18 h, 24 h
Result: Reduced procaspase-3 and increased cleaved caspase-3 in cells.
Reduced procaspase-8 in cells.
Lead to early activation of JNK.
Molecular Weight

2577.05

Formula

C119H194N28O33S
CAS No.
Sequence Shortening

LVFFAEDVGSNKGAIIGLMVGGVVIA
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Purity & Documentation
References
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Amyloid 17-42 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amyloid 17-42155178-13-5Aβ(17-42)ApoptosisAlzheimer's diseaseDown's syndromethe amyloid precursor protein (APP)neuronalapoptosisInhibitorinhibitorinhibit

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