155178-13-5
155178-13-5
Chemical Structure
Amyloid 17-42
Synonym(s): Aβ(17-42)
- CAS No.: 155178-13-5
- Formula:C119H194N28O33S
- Molecular Weight:2577.05
SMILES: [LVFFAEDVGSNKGAIIGLMVGGVVIA]
Biological Activity: Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway[1].
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Amyloid 17-42 | Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway. | |||||||||||||||||||||
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References
Keywords
