2. Neuronal Signaling Stem Cell/Wnt
  3. γ-secretase
  4. DAPT

DAPT (GSI-IX) (GMP) is DAPT (HY-13027) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DAPT is a potent and orally active γ-secretase inhibitor.

For research use only. We do not sell to patients.

DAPT

DAPT Chemical Structure

CAS No. : 208255-80-5

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Based on 1 publication(s) in Google Scholar

DAPT Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DAPT (GSI-IX) (GMP) is DAPT (HY-13027) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DAPT is a potent and orally active γ-secretase inhibitor[1][2].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
34200 nM
Compound: DAPT
Displacement of [3H]L685458 from human SPP expressed in HEK293 cells
Displacement of [3H]L685458 from human SPP expressed in HEK293 cells
[PMID: 17932033]
Hep 3B2 IC50
5 μM
Compound: DAPT
Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by SRB assay
[PMID: 30108693]
Huh-7 IC50
5 μM
Compound: DAPT
Cytotoxicity against human HuH7 cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human HuH7 cells assessed as growth inhibition after 72 hrs by SRB assay
[PMID: 30108693]
Mahlavu IC50
5 μM
Compound: DAPT
Cytotoxicity against human Mahlavu cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human Mahlavu cells assessed as growth inhibition after 72 hrs by SRB assay
[PMID: 30108693]
SNU-475 IC50
0.6 μM
Compound: DAPT
Cytotoxicity against human SNU475 cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human SNU475 cells assessed as growth inhibition after 72 hrs by SRB assay
[PMID: 30108693]
THP-1 IC50
6.3 nM
Compound: DAPT
Displacement of [3H]IN973 from gamma-secretase in human THP1 cells
Displacement of [3H]IN973 from gamma-secretase in human THP1 cells
[PMID: 17932033]
THP-1 IC50
> 100000 nM
Compound: DAPT
Displacement of [3H]L685458 from gamma-secretase in human THP1 cells
Displacement of [3H]L685458 from gamma-secretase in human THP1 cells
[PMID: 17932033]
In Vitro

DAPT (GMP) (9 d) induces human induced pluripotent stem cells develop into expandable myoblasts[1].
DAPT (GMP) (13 d) induces human pluripotent stem cells (hPSCs) develop into functional neurons[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DAPT Related Antibodies
Molecular Weight

432.46

Formula

C23H26F2N2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=CC(F)=CC(CC(N[C@H](C(N[C@H](C(OC(C)(C)C)=O)C2=CC=CC=C2)=O)C)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DAPT Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DAPT (GMP)208255-80-5GSI-IX (GMP)γ-secretaseGamma secretaseGMPcell therapy manufacturepotentoralhiPSCmyoblastneuronsInhibitorinhibitorinhibit

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