Based on 1 Customer Validation
DAPT (GSI-IX) (GMP) is DAPT (HY-13027) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DAPT is a potent and orally active γ-secretase inhibitor.
For research use only. We do not sell to patients.
- CAS No.: 208255-80-5
- Formula: C23H26F2N2O4
- Molecular Weight:432.46
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
34200 nM
Compound: DAPT
|
Displacement of [3H]L685458 from human SPP expressed in HEK293 cells
Displacement of [3H]L685458 from human SPP expressed in HEK293 cells
|
[PMID: 17932033] |
| Hep 3B2 | IC50 |
5 μM
Compound: DAPT
|
Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by SRB assay
|
[PMID: 30108693] |
| Huh-7 | IC50 |
5 μM
Compound: DAPT
|
Cytotoxicity against human HuH7 cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human HuH7 cells assessed as growth inhibition after 72 hrs by SRB assay
|
[PMID: 30108693] |
| Mahlavu | IC50 |
5 μM
Compound: DAPT
|
Cytotoxicity against human Mahlavu cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human Mahlavu cells assessed as growth inhibition after 72 hrs by SRB assay
|
[PMID: 30108693] |
| SNU-475 | IC50 |
0.6 μM
Compound: DAPT
|
Cytotoxicity against human SNU475 cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against human SNU475 cells assessed as growth inhibition after 72 hrs by SRB assay
|
[PMID: 30108693] |
| THP-1 | IC50 |
6.3 nM
Compound: DAPT
|
Displacement of [3H]IN973 from gamma-secretase in human THP1 cells
Displacement of [3H]IN973 from gamma-secretase in human THP1 cells
|
[PMID: 17932033] |
| THP-1 | IC50 |
>100000 nM
Compound: DAPT
|
Displacement of [3H]L685458 from gamma-secretase in human THP1 cells
Displacement of [3H]L685458 from gamma-secretase in human THP1 cells
|
[PMID: 17932033] |
DAPT (GMP) (9 d) induces human induced pluripotent stem cells develop into expandable myoblasts[1]. DAPT (GMP) (13 d) induces human pluripotent stem cells (hPSCs) develop into functional neurons[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 208255-80-5
-
Appearance Solid
-
Molecular Weight 432.46
-
Formula C23H26F2N2O4
-
Color White to off-white
-
SMILES
FC1=CC(F)=CC(CC(N[C@H](C(N[C@H](C(OC(C)(C)C)=O)C2=CC=CC=C2)=O)C)=O)=C1
-
Synonyms
GSI-IX (GMP)
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (266 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Choi IY, et al. Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model. Cell Rep. 2016 Jun 7;15(10):2301-2312. [Content Brief]
[2]. Qi Y, et al. Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells. Nat Biotechnol. 2017 Feb;35(2):154-163. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DAPT (GMP) Related Classifications
HY-13027G Related Classifications
Powered by Bioz