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Cat. No.: HY-117957

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BMS-932481

BMS-932481 is an orally active modulator for γ-secretase, selectively reduce Aβ1-42 and Aβ1-40 production, with IC₅₀s of 6.6 and 25.3 nM, respectively.

For research use only. We do not sell to patients.

CAS No.: 1263871-36-8
Formula: C₂₄H₂₄FN₇O
Molecular Weight:445.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

BMS-932481 Chemical Structure

CAS No.: 1263871-36-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

BMS-932481 is an orally active modulator for γ-secretase, selectively reduce Aβ1-42 and Aβ1-40 production, with IC₅₀s of 6.6 and 25.3 nM, respectively^[1].

In Vivo

BMS-932481 (2-30 mg/kg, po, single dose) reduces the levels of Aβ1-42 and Aβ1-40, increases levels of Aβ1-38 and Aβ1-37, without changing overall amounts of Aβ peptides in dog models^[1].
BMS-932481 (2.5-15 mg/kg, iv, single dose) exhibits moderate brain penetration with brain-to-plasma ratio and AUC_brain to AUC_plasma ratio of about 0.23 and 0.6 in Sprague-Dawley rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Beague dog model^[1]
Dosage:

2-30 mg/kg
Administration:

po, single dose
Result:

Reduced levels of Aβ1-42 and Aβ1- 40 of 65% with 30 mg/kg dose, increased levels of Aβ1-38 and Aβ1-37 by 1.8 and 5 fold.

Chemical Information

CAS No. 1263871-36-8
Molecular Weight 445.49
Formula C₂₄H₂₄FN₇O
SMILES

CNC1=C(CC[C@H]2C3=CC=C(F)C=C3)C2=NC(NC4=CC=C(N5N=C(C)N=C5)C(OC)=C4)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Toyn JH, et al., Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects. J Pharmacol Exp Ther. 2016 Jul;358(1):125-37. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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