1. Neuronal Signaling
  2. Beta-secretase

BACE1-IN-2 

Cat. No.: HY-112444
Handling Instructions

BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC50 of 22 nM.

For research use only. We do not sell to patients.

BACE1-IN-2 Chemical Structure

BACE1-IN-2 Chemical Structure

CAS No. : 1352416-78-4

Size Stock
250 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC50 of 22 nM[1].

IC50 & Target

IC50: 22 nM (BACE1)[1]

In Vitro

BACE1-IN-2 (Compound 3) is 10-fold more potent toward BACE1 than BACE2, inhibition of which may lead to hair depigmentation. BACE1-IN-2 inhibits hAβ42 cell with an IC50 of 6.0 nM[1].

References
Molecular Weight

421.35

Formula

C₁₉H₁₅F₄N₅O₂

CAS No.

1352416-78-4

SMILES

NC1=N[[email protected]@](C2=C(F)C=CC(NC(C3=CC=C(C#N)C=N3)=O)=C2)(C)[[email protected]](C(F)(F)F)OC1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
BACE1-IN-2
Cat. No.:
HY-112444
Quantity:

BACE1-IN-2

Cat. No.: HY-112444