γ-Secretase modulator 4

Cat. No.: HY-128581 Purity: 99.47%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC₅₀s of 0.014 μM and 0.017 μM in human and mouse, respectively.

For research use only. We do not sell to patients.

γ-Secretase modulator 4 Chemical Structure

CAS No. : 1420200-82-3

Size	Price	Stock	Quantity
1 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1050	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1775	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 3550	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 6000	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 9990	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC₅₀s of 0.014 μM and 0.017 μM in human and mouse, respectively^[1].

IC₅₀ & Target

IC50: 0.014 μM (Aβ42, human), 0.017 μM (Aβ42, mouse)^[1]

Molecular Weight

402.42

Formula

C₂₃H₁₉FN₄O₂

CAS No.

1420200-82-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

N#CC1=C(OC)C2=C(C=C1)NC(C3=CN(CCO[C@H]4C5=CC=CC(F)=C5C)C4=N3)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (248.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4850 mL	12.4248 mL	24.8497 mL
5 mM	0.4970 mL	2.4850 mL	4.9699 mL
10 mM	0.2485 mL	1.2425 mL	2.4850 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.47%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (251 KB) HNMR (185 KB) RP-HPLC (268 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Bischoff FP, et al. Design and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1737-1745. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4850 mL	12.4248 mL	24.8497 mL	62.1241 mL
	5 mM	0.4970 mL	2.4850 mL	4.9699 mL	12.4248 mL
	10 mM	0.2485 mL	1.2425 mL	2.4850 mL	6.2124 mL
	15 mM	0.1657 mL	0.8283 mL	1.6566 mL	4.1416 mL
	20 mM	0.1242 mL	0.6212 mL	1.2425 mL	3.1062 mL
	25 mM	0.0994 mL	0.4970 mL	0.9940 mL	2.4850 mL
	30 mM	0.0828 mL	0.4142 mL	0.8283 mL	2.0708 mL
	40 mM	0.0621 mL	0.3106 mL	0.6212 mL	1.5531 mL
	50 mM	0.0497 mL	0.2485 mL	0.4970 mL	1.2425 mL
	60 mM	0.0414 mL	0.2071 mL	0.4142 mL	1.0354 mL
	80 mM	0.0311 mL	0.1553 mL	0.3106 mL	0.7766 mL
	100 mM	0.0248 mL	0.1242 mL	0.2485 mL	0.6212 mL