2. Neuronal Signaling Stem Cell/Wnt
  3. Cholinesterase (ChE) Beta-secretase γ-secretase
  4. SSZ

SSZ is a multi-target inhibitor, which targets multiple pathological mechanisms of Alzheimer's disease (AD). SSZ targets acetylcholinesterase, butyrylcholinesterase, β-site amyloid precursor protein cleavage enzyme 1 (BACE1), and γ-secretase. SSZ ameliorates Alzheimer’s diseases and exhibits neuroprotective effect in mice.

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SSZ

SSZ Chemical Structure

CAS No. : 1262287-23-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

SSZ Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE SSZ

View All Cholinesterase (ChE) Isoform Specific Products:

View All Isoforms
AChE BChE

View All Beta-secretase Isoform Specific Products:

View All Isoforms
BACE1 BACE2

  • Biological Activity

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Description

SSZ is a multi-target inhibitor, which targets multiple pathological mechanisms of Alzheimer's disease (AD). SSZ targets acetylcholinesterase, butyrylcholinesterase, β-site amyloid precursor protein cleavage enzyme 1 (BACE1), and γ-secretase. SSZ ameliorates Alzheimer’s diseases and exhibits neuroprotective effect in mice[1].

Clinical Trial
Molecular Weight

326.82

Formula

C18H19ClN4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

ClC1=CC(C2=CNC3=C2C=CC=N3)=CC(NC4CCCCC4)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (152.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0598 mL 15.2989 mL 30.5979 mL
5 mM 0.6120 mL 3.0598 mL 6.1196 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0598 mL 15.2989 mL 30.5979 mL 76.4947 mL
5 mM 0.6120 mL 3.0598 mL 6.1196 mL 15.2989 mL
10 mM 0.3060 mL 1.5299 mL 3.0598 mL 7.6495 mL
15 mM 0.2040 mL 1.0199 mL 2.0399 mL 5.0996 mL
20 mM 0.1530 mL 0.7649 mL 1.5299 mL 3.8247 mL
25 mM 0.1224 mL 0.6120 mL 1.2239 mL 3.0598 mL
30 mM 0.1020 mL 0.5100 mL 1.0199 mL 2.5498 mL
40 mM 0.0765 mL 0.3825 mL 0.7649 mL 1.9124 mL
50 mM 0.0612 mL 0.3060 mL 0.6120 mL 1.5299 mL
60 mM 0.0510 mL 0.2550 mL 0.5100 mL 1.2749 mL
80 mM 0.0382 mL 0.1912 mL 0.3825 mL 0.9562 mL
100 mM 0.0306 mL 0.1530 mL 0.3060 mL 0.7649 mL
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SSZ Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SSZ1262287-23-9Cholinesterase (ChE)Beta-secretaseγ-secretaseBACEβ-Secretase Gamma secretaseAlzheimer’s Diseaseneuroprotectivemulti-targetInhibitorinhibitorinhibit

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