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Cat. No.: HY-19550

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PF-06442609

PF-06442609 is an orally active γ secretase modulator, with an IC₅₀ of 6 nM for Aβ42. PF-06442609 possesses brain good penetration.

For research use only. We do not sell to patients.

CAS No.: 1402002-76-9
Formula: C₂₄H₂₄F₄N₄O₃
Molecular Weight:492.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PF-06442609 Chemical Structure

CAS No.: 1402002-76-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PF-06442609 is an orally active γ secretase modulator, with an IC₅₀ of 6 nM for Aβ42. PF-06442609 possesses brain good penetration^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	6 nM Compound: 21, PF-06442609	Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production after 24 hrs by ELISA Modulation of human gamma secretase overexpressed in CHO cells co-expressing wild type human APP assessed as inhibition of amyloid beta-42 production after 24 hrs by ELISA	[PMID: 26005540]
CHO-K1	IC₅₀	9.2 μM Compound: 21, PF-06442609	Inhibition of human ERG expressed in CHOK1 cells by patch clamp assay Inhibition of human ERG expressed in CHOK1 cells by patch clamp assay	[PMID: 26005540]

Chemical Information

CAS No. 1402002-76-9
Molecular Weight 492.47
Formula C₂₄H₂₄F₄N₄O₃
SMILES

O=C1C(N2CCN1[C@@H](C)COC3=CC=C(F)C=C3[C@@H](C)C(F)(F)F)=CC=C(N4C=C(C)N=C4)C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Martin Pettersson, et al. Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability. ACS Med Chem Lett. 2015 Apr 3;6(5):596-601. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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