2. Neuronal Signaling Stem Cell/Wnt
  3. γ-secretase
  4. PF-06648671

PF-06648671 is a novel, brain-penetrable, and orally active γ-secretase modulator (GSM). PF-06648671 reduces Aβ42 and Aβ40, with concomitant increases in Aβ37 and Aβ38 in vitro. PF-06648671 is used for the study of Alzheimer’s disease.

For research use only. We do not sell to patients.

PF-06648671 Chemical Structure

PF-06648671 Chemical Structure

CAS No. : 1587727-31-8

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Based on 1 publication(s) in Google Scholar

PF-06648671 Related Antibodies

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Description

PF-06648671 is a novel, brain-penetrable, and orally active γ-secretase modulator (GSM). PF-06648671 reduces Aβ42 and Aβ40, with concomitant increases in Aβ37 and Aβ38 in vitro. PF-06648671 is used for the study of Alzheimer’s disease[1].
IC50 & Target

IC50: γ-secretase[1]
In Vitro

In a cell-based assay, PF-06648671 reduces Aβ42 and Aβ40 , with concomitant increases in Aβ37 and Aβ38, without inhibiting the cleavage of Notch or other substrates[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF-06648671 Related Antibodies
In Vivo

PF-06648671 demonstrates reduces Aβ42 within the brain and CSF following acute oral administration in animals[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

538.92

Formula

C25H23ClF4N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(F)(C(C=C1Cl)=C([C@](CC2)([H])O[C@]2([H])[C@@H](N(CCN3C4=CC=C(N5C=NC(C)=C5)C3=O)C4=O)C)C=C1F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 98.12%

COA (249 KB) LCMS (89 KB)

Handling Instructions (2659 KB)
References
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PF-06648671 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-066486711587727-31-8PF06648671PF 06648671γ-secretaseGamma secretaseInhibitorinhibitorinhibit

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