1. Neuronal Signaling
    Stem Cell/Wnt
  2. γ-secretase
  3. PF-06648671

PF-06648671 

Cat. No.: HY-120789
Handling Instructions

PF-06648671 is a novel, brain‐penetrable, and orally active γ‐secretase modulator (GSM). PF-06648671 reduces Aβ42 and Aβ40, with concomitant increases in Aβ37 and Aβ38 in vitro. PF-06648671 is used for the study of Alzheimer’s disease.

For research use only. We do not sell to patients.

PF-06648671 Chemical Structure

PF-06648671 Chemical Structure

CAS No. : 1587727-31-8

Size Price Stock Quantity
1 mg USD 580 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
10 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

PF-06648671 is a novel, brain‐penetrable, and orally active γ‐secretase modulator (GSM). PF-06648671 reduces Aβ42 and Aβ40, with concomitant increases in Aβ37 and Aβ38 in vitro. PF-06648671 is used for the study of Alzheimer’s disease[1].

IC50 & Target

IC50: γ‐secretase[1]

In Vitro

In a cell‐based assay, PF‐06648671 reduces Aβ42 and Aβ40 , with concomitant increases in Aβ37 and Aβ38, without inhibiting the cleavage of Notch or other substrates[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PF‐06648671 demonstrates reduces Aβ42 within the brain and CSF following acute oral administration in animals[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

538.92

Formula

C25H23ClF4N4O3

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References
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Product Name:
PF-06648671
Cat. No.:
HY-120789
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