2. Neuronal Signaling Stem Cell/Wnt
  3. γ-secretase
  4. III-31-C

III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor. III-31-C inhibits Aऔ production with an IC50 of 10 nM in the cell-free γ-secretase assay and 200 nM in APP-transfected cells. III-31-C can be used in Alzheimer's disease research.

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III-31-C

III-31-C Chemical Structure

CAS No. : 398515-96-3

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III-31-C Related Antibodies

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Description

III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor. III-31-C inhibits Aऔ production with an IC50 of 10 nM in the cell-free γ-secretase assay and 200 nM in APP-transfected cells. III-31-C can be used in Alzheimer's disease research[1].

Cellular Effect
Cell Line Type Value Description References
CHO IC50
0.22 μM
Compound: 15
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP)
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP)
[PMID: 15050631]
CHO IC50
0.4 μM
Compound: 31c
Inhibition of gamma secretase in CHO cells expressing human APP after 4 hrs by ELISA
Inhibition of gamma secretase in CHO cells expressing human APP after 4 hrs by ELISA
[PMID: 15588083]
CHO IC50
0.4 μM
Compound: 31c
Inhibition of gamma secretase in CHO cells expressing human APP by ELISA
Inhibition of gamma secretase in CHO cells expressing human APP by ELISA
[PMID: 15588083]
CHO IC50
18 μM
Compound: 31c
Inhibition of gamma secretase in CHO cells expressing human APP after 24 hrs by ELISA
Inhibition of gamma secretase in CHO cells expressing human APP after 24 hrs by ELISA
[PMID: 15588083]
HeLa IC50
0.01 μM
Compound: 31c
Inhibition of gamma secretase isolated from HeLa cells by ELISA
Inhibition of gamma secretase isolated from HeLa cells by ELISA
[PMID: 15588083]
Molecular Weight

640.81

Formula

C35H52N4O7
CAS No.
SMILES

O=C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(OC)=O)=O)N(C[C@@H](O)[C@@H](NC(OC(C)(C)C)=O)CC1=CC=CC=C1)CC2=CC=CC=C2
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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III-31-C Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

III-31-C398515-96-3γ-secretaseGamma secretaseHeLaADpresenilincarboxybenzoyl.Inhibitorinhibitorinhibit

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