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Cat. No.: HY-139052

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III-31-C

III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor. III-31-C inhibits Aऔ production with an IC₅₀ of 10 nM in the cell-free γ-secretase assay and 200 nM in APP-transfected cells. III-31-C can be used in Alzheimer's disease research.

For research use only. We do not sell to patients.

CAS No.: 398515-96-3
Formula: C₃₅H₅₂N₄O₇
Molecular Weight:640.81

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

III-31-C Chemical Structure

CAS No.: 398515-96-3

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.22 μM Compound: 15	Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP)	[PMID: 15050631]
CHO	IC₅₀	0.4 μM Compound: 31c	Inhibition of gamma secretase in CHO cells expressing human APP after 4 hrs by ELISA Inhibition of gamma secretase in CHO cells expressing human APP after 4 hrs by ELISA	[PMID: 15588083]
CHO	IC₅₀	0.4 μM Compound: 31c	Inhibition of gamma secretase in CHO cells expressing human APP by ELISA Inhibition of gamma secretase in CHO cells expressing human APP by ELISA	[PMID: 15588083]
CHO	IC₅₀	18 μM Compound: 31c	Inhibition of gamma secretase in CHO cells expressing human APP after 24 hrs by ELISA Inhibition of gamma secretase in CHO cells expressing human APP after 24 hrs by ELISA	[PMID: 15588083]
HeLa	IC₅₀	0.01 μM Compound: 31c	Inhibition of gamma secretase isolated from HeLa cells by ELISA Inhibition of gamma secretase isolated from HeLa cells by ELISA	[PMID: 15588083]

Chemical Information

CAS No. 398515-96-3
Molecular Weight 640.81
Formula C₃₅H₅₂N₄O₇
SMILES

O=C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(OC)=O)=O)N(C[C@@H](O)[C@@H](NC(OC(C)(C)C)=O)CC1=CC=CC=C1)CC2=CC=CC=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kornilova AY, et al. Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications. J Biol Chem. 2003 May 9;278(19):16470-3. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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