2. Neuronal Signaling Stem Cell/Wnt
  3. γ-secretase
  4. GSI-136

GSI-136 is an inhibitor of γ-secretase with an IC50 of 3 nM. GSI-136 can lead to a dose-dependent reduction of Aβ40 levels in diethylamine-extracted brain homogenates of C57BL/6 mice. GSI-136 can be studied in medicinal chemistry and Alzheimer's disease research.

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GSI-136

GSI-136 Chemical Structure

CAS No. : 443989-01-3

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GSI-136 Related Antibodies

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Description

GSI-136 is an inhibitor of γ-secretase with an IC50 of 3 nM. GSI-136 can lead to a dose-dependent reduction of Aβ40 levels in diethylamine-extracted brain homogenates of C57BL/6 mice. GSI-136 can be studied in medicinal chemistry and Alzheimer's disease research[1].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
29 nM
Compound: 1
Inhibition of gamma-secretase-mediated cleavage of human APP expressed in CHO cells assessed as reduction in amyloid beta40 production after 24 hrs by double sandwich ELISA
Inhibition of gamma-secretase-mediated cleavage of human APP expressed in CHO cells assessed as reduction in amyloid beta40 production after 24 hrs by double sandwich ELISA
[PMID: 19443228]
CHO EC50
29 nM
Compound: 1
Inhibition of gamma-secretase-mediated cleavage of human APP expressed in CHO cells assessed as reduction in amyloid beta42 production after 24 hrs by double sandwich ELISA
Inhibition of gamma-secretase-mediated cleavage of human APP expressed in CHO cells assessed as reduction in amyloid beta42 production after 24 hrs by double sandwich ELISA
[PMID: 19443228]
CHO IC50
25 nM
Compound: 9
Inhibition of gamma-secretase expressed in CHO cells expressing human recombinant APP assessed as amyloid beta40 aggregation
Inhibition of gamma-secretase expressed in CHO cells expressing human recombinant APP assessed as amyloid beta40 aggregation
[PMID: 19012391]
Clinical Trial
Molecular Weight

311.85

Formula

C11H18ClNO3S2
CAS No.
SMILES

O=S(C1=CC=C(S1)Cl)(N[C@H](CO)C(CC)CC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GSI-136 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSI-136443989-01-3GSI136GSI 136γ-secretaseGamma secretaseInhibitorinhibitorinhibit

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