443989-01-3
443989-01-3
Chemical Structure
GSI-136
- CAS No.: 443989-01-3
- Formula:C11H18ClNO3S2
- Molecular Weight:311.85
IUPAC Name: (S)-5-chloro-N-(3-ethyl-1-hydroxypentan-2-yl)thiophene-2-sulfonamide
InChIKey: PYZFRRVBPNGCBX-SECBINFHSA-N
SMILES: O=S(C1=CC=C(S1)Cl)(N[C@H](CO)C(CC)CC)=O
Biological Activity: GSI-136 is an inhibitor of γ-secretase with an IC50 of 3 nM. GSI-136 can lead to a dose-dependent reduction of Aβ40 levels in diethylamine-extracted brain homogenates of C57BL/6 mice. GSI-136 can be studied in medicinal chemistry and Alzheimer's disease research[1].
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GSI-136 | GSI-136 is an inhibitor of γ-secretase with an IC50 of 3 nM. GSI-136 can lead to a dose-dependent reduction of Aβ40 levels in diethylamine-extracted brain homogenates of C57BL/6 mice. GSI-136 can be studied in medicinal chemistry and Alzheimer's disease research. | |||||||||||||||||||||
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