1. Neuronal Signaling
    Stem Cell/Wnt
  2. γ-secretase
    Notch
  3. BMS-906024

BMS-906024 

Cat. No.: HY-15670
Handling Instructions

BMS-906024 is an oral and selective gamma secretase inhibitor (GSI) that is a small molecule Notch inhibitor. BMS-906024 prevents the activation of all four Notch receptors with a high oral bioavailability with IC50s of 1.6, 0.7, 3.4, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity against a wide array of human cancer xenografts.

For research use only. We do not sell to patients.

BMS-906024 Chemical Structure

BMS-906024 Chemical Structure

CAS No. : 1401066-79-2

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Description

BMS-906024 is an oral and selective gamma secretase inhibitor (GSI) that is a small molecule Notch inhibitor[1]. BMS-906024 prevents the activation of all four Notch receptors with a high oral bioavailability with IC50s of 1.6, 0.7, 3.4, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity against a wide array of human cancer xenografts[2].

IC50 & Target

IC50: 1.6 nM (Notch1), 0.7 nM (Notch2), 3.4 nM (Notch3) and 2.9 nM (Notch4)[2]

Molecular Weight

556.50

Formula

C₂₆H₂₆F₆N₄O₃

CAS No.

1401066-79-2

SMILES

O=C(N[[email protected]@H]1C(N(C)C2=CC=CC=C2C(C3=CC=CC=C3)=N1)=O)[[email protected]](CCC(F)(F)F)[[email protected]](CCC(F)(F)F)C(N)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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