1. Neuronal Signaling
    Stem Cell/Wnt
  2. γ-secretase
  3. SPL-707

SPL-707 

Cat. No.: HY-111360
Handling Instructions

SPL-707 is an orally active, selective signal peptide peptidase-like 2a (SPPL2a) inhibitor with an IC50 of 77 nM for hSPPL2a. SPL-707 inhibits γ-secretase (IC50=6.1 μM) and SPP (IC50=3.7 μM). SPL-707 has the potential for autoimmune diseases research by targeting B cells and dendritic cells.

For research use only. We do not sell to patients.

SPL-707 Chemical Structure

SPL-707 Chemical Structure

CAS No. : 2195361-33-0

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SPL-707 is an orally active, selective signal peptide peptidase-like 2a (SPPL2a) inhibitor with an IC50 of 77 nM for hSPPL2a. SPL-707 inhibits γ-secretase (IC50=6.1 μM) and SPP (IC50=3.7 μM). SPL-707 has the potential for autoimmune diseases research by targeting B cells and dendritic cells[1].

IC50 & Target

IC50: 77 nM (SPPL2a), 6.1 μM (γ-secretase) and 3.7 μM (SPP)[1]

In Vitro

SPL-707 (Compound 40) inhibits mouse SPPL2a (IC50=0.18 μM), rat SPPL2a (IC50=0.056 μM) and human SPPL2a (IC50=0.16 μM), human SPPL2b (IC50=0.43 μM) by a high content imaging assay (HCA)[1].

In Vivo

SPL-707 (Compound 40; 3-30 mg/kg; orally; b.i.d.; for 11 days) leads to a reduction in B cells and myeloid dendritic cells without affecting γ-secretase activity[1].
SPL-707 (3 mg/kg of po and 1 mg/kg of iv) has a CL of 6 mL/min•kg, and an AUC of 8787 h•nM[1].
SPL-707 (1, 3 mg/kg; b.i.d.; first dose at 0 h, second dose at 8 h) achieves full inhibition of CD74/p8 processing in spleen in female Lewis rats[1].

Animal Model: Mice with 5-12 weeks of age[1]
Dosage: 3, 10, and 30 mg/kg
Administration: Orally; b.i.d. (with 8 and 16 h dosing intervals); for 11 days
Result: Led to a reduction in B cells and myeloid dendritic cells without affecting γ-secretase activity.
Animal Model: Female Sprague−Dawley rat[1]
Dosage: 3 mg/kg of po and 1 mg/kg of iv (Pharmacokinetic Analysis)
Administration: PO or IV
Result: Had a CL of 6 mL/min•kg, and an AUC of 8787 h•nM.
Molecular Weight

505.54

Formula

C₂₇H₂₈FN₅O₄

CAS No.

2195361-33-0

SMILES

CC1=C(NC(C[[email protected]@H](C2CC2)C(N[[email protected]@H]3C(N(CC4(CC4)C5)N5C(C6=C3C=CC=C6)=O)=O)=O)=O)C=C(F)C=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SPL-707SPL707SPL 707γ-secretaseGamma secretaseorallysignalpeptidepeptidase-like2aSPPL2ahSPPL2aSPPautoimmuneB cellsdendriticSPPL2bInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
SPL-707
Cat. No.:
HY-111360
Quantity:
MCE Japan Authorized Agent: