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Cat. No.: HY-138013

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PF-06663195

PF-06663195 is a β-secretase (BACE1) inhibitor, with BACE1 CFA and BACE1 WCA IC₅₀ values of 53 and 15 nM, respectively. PF-06663195 can be used for Alzheimer's disease research.

For research use only. We do not sell to patients.

CAS No.: 1621585-22-5
Formula: C₁₈H₁₈F₃N₃O₂S
Molecular Weight:397.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

PF-06663195 Chemical Structure

CAS No.: 1621585-22-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PF-06663195 is a β-secretase (BACE1) inhibitor, with BACE1 CFA and BACE1 WCA IC₅₀ values of 53 and 15 nM, respectively. PF-06663195 can be used for Alzheimer's disease research^[1].

All Beta-secretase Isoforms :

BACE1
BACE2

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	10.1 μM Compound: 13	Inhibition of human ERG expressed in CHO cells Inhibition of human ERG expressed in CHO cells	[PMID: 25781223]
H4	IC₅₀	53 nM Compound: 13	Inhibition of BACE1 in human H4 cells overexpressing wild type human APP695 assessed as colorimetric reaction by Whole cell assay Inhibition of BACE1 in human H4 cells overexpressing wild type human APP695 assessed as colorimetric reaction by Whole cell assay	[PMID: 25781223]

Chemical Information

CAS No. 1621585-22-5
Molecular Weight 397.41
Formula C₁₈H₁₈F₃N₃O₂S
SMILES

FC[C@@H]1[C@@]2([H])[C@](N=C(S1)N)(C3=C(C=C(C=C3)F)F)CO[C@@H](C4=CC(C)=NO4)C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology Animals and Diseases

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Michael A Brodney, et al. Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors. J Med Chem. 2015 Apr 9;58(7):3223-52. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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