Aβ42-IN-1
Aβ42-IN-1, compound 1v, is a novel, potent and orally active?γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels with an IC50?value of 0.091?μM without CYP3A4 inhibition. Aβ42-IN-1 shows a sustained pharmacokinetic profile.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2582757-69-3
- 分子式: C29H27ClN4O2
- 分子量:499.00
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 0.091 µM (γ-secretase modulator)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8- week-old male ddY mice
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Dosage:30 mg/kg
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Administration:Orally adminstation; 30 mg/kg
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Result:Reduced Aβ42 levels in the brain and plasma, by 36% and 66%, respectively.
化学情報
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CAS 番号 2582757-69-3
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分子量 499.00
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分子式 C29H27ClN4O2
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SMILES
O=C(C1=NC=C(C2=C(C)N=C3C(OCC4=CC=C(C5=CC=CC=C5)C=C4)=CC=CN32)C=C1)NCC.[H]Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Aβ42-IN-1 関連分類
HY-130609 関連分類
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