Aβ42-IN-1 free base
Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposure γ-secretase modulator. Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC50 value of 0.091 μM, and significantly reduces brain Aβ42 levels in mice. Aβ42-IN-1 free base is a promising compound for the treatment of Alzheimer’s disease.
For research use only. We do not sell to patients.
- CAS No.: 2434633-17-5
- Formula: C29H26N4O2
- Molecular Weight:462.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nonfasted 8-week-old male ddY mice[1]
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Dosage:30 mg/kg
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Administration:p.o. (Pharmacokinetic Analysis)
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Result:The CLint is 84.7 µL/min/mg protein.
Chemical Information
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CAS No. 2434633-17-5
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Molecular Weight 462.54
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Formula C29H26N4O2
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SMILES
O=C(C1=NC=C(C2=C(C)N=C3C(OCC4=CC=C(C5=CC=CC=C5)C=C4)=CC=CN32)C=C1)NCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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