2582757-69-3
2582757-69-3
Chemical Structure
Aβ42-IN-1
- CAS No.: 2582757-69-3
- Formula:C29H27ClN4O2
- Molecular Weight:499.00
IUPAC Name: 5-(8-([1,1'-biphenyl]-4-ylmethoxy)-2-methylimidazo[1,2-a]pyridin-3-yl)-N-ethylpicolinamide hydrochloride
InChIKey: PXGSUAWOGFXNSZ-UHFFFAOYSA-N
SMILES: O=C(C1=NC=C(C2=C(C)N=C3C(OCC4=CC=C(C5=CC=CC=C5)C=C4)=CC=CN32)C=C1)NCC.[H]Cl
Biological Activity: Aβ42-IN-1, compound 1v, is a novel, potent and orally active?γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels with an IC50?value of 0.091?μM without CYP3A4 inhibition. Aβ42-IN-1 shows a sustained pharmacokinetic profile.
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Aβ42-IN-1 | Aβ42-IN-1, compound 1v, is a novel, potent and orally active?γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels with an IC50?value of 0.091?μM without CYP3A4 inhibition. Aβ42-IN-1 shows a sustained pharmacokinetic profile. | |||||||||||||||||||||
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