(Rac)-BIIB042
(Rac)-BIIB042 (Compound 10) is an modulator of γ-Secretase. (Rac)-BIIB042 reduces Amyloid-β 42 level with an EC50 value of 0.39 µM. (Rac)-BIIB042 can be used for the study of Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 1257395-14-4
- Formula: C29H29F4NO2
- Molecular Weight:499.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
0.39 μM
Compound: 10
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Modulation of gamma-secretase in CHO cells overexpressing APP V717 mutant assessed as reduction in amyloid beta42 level after 17 hrs by ELISA
Modulation of gamma-secretase in CHO cells overexpressing APP V717 mutant assessed as reduction in amyloid beta42 level after 17 hrs by ELISA
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[PMID: 24900267] |
Chemical Information
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CAS No. 1257395-14-4
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Molecular Weight 499.54
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Formula C29H29F4NO2
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SMILES
OC(C(C)C(C=C1)=CC(C2=CC=C(C(F)(F)F)C=C2)=C1C(N3CCC(C)CC3)C4=CC=C(F)C=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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