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Results for "

β-lactamase inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Beta-lactamase (163) Angiotensin-converting Enzyme (ACE) (5) Antibiotic (90) Apoptosis (13) Autophagy (6) Bacterial (182) Bcl-2 Family (1) Drug Derivative (1) Drug Intermediate (3) Endogenous Metabolite (2) Environmental Pollutants (1) Fluorescent Dye (1) Fungal (1) GABA Receptor (8) HDAC (16) Interleukin Related (5) Isotope-Labeled Compounds (12) Penicillin-binding protein (PBP) (11) PKC (1) Reference Standards (36) TNF Receptor (1) Toll-like Receptor (TLR) (1) Virus Protease (3)
By Research Areas:	Cancer (33) Cardiovascular Disease (9) Infection (199) Inflammation/Immunology (12) Metabolic Disease (3) Neurological Disease (2)

By Targets:

Beta-lactamase (163)

Angiotensin-converting Enzyme (ACE) (5)

Antibiotic (90)

Apoptosis (13)

Autophagy (6)

Bacterial (182)

Bcl-2 Family (1)

Drug Derivative (1)

Drug Intermediate (3)

Endogenous Metabolite (2)

Environmental Pollutants (1)

Fluorescent Dye (1)

Fungal (1)

GABA Receptor (8)

HDAC (16)

Interleukin Related (5)

Isotope-Labeled Compounds (12)

Penicillin-binding protein (PBP) (11)

PKC (1)

Reference Standards (36)

TNF Receptor (1)

Toll-like Receptor (TLR) (1)

Virus Protease (3)

By Research Areas:

Cancer (33)

Cardiovascular Disease (9)

Infection (199)

Inflammation/Immunology (12)

Metabolic Disease (3)

Neurological Disease (2)

229

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

GMP Molecules

Targets Recommended: Beta-lactamase Serpin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14879A

Avibactam sodium Maximum Cited Publications 92 Publications Verification NXL-104	Beta-lactamase Bacterial Antibiotic	Infection
Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam *β-lactamase* inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively .

HY-19930

Vaborbactam 40+ Cited Publications RPX7009	Beta-lactamase Bacterial	Infection
Vaborbactam (RPX7009) is a cyclic boronic acid pharmacophore *β-lactamase* inhibitor.

HY-117974

Durlobactam sodium 5+ Cited Publications ETX2514	Bacterial	Infection
Durlobactam sodium salt (ETX2514) is a broad-spectrum *β-lactamase* inhibitor with IC₅₀s of 4, 14 and 190 nM for Class A KPC-2, Class C AmpC and Class D OXA-24, respectively. For the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii .

HY-120859

Zidebactam 5+ Cited Publications WCK-5107	Beta-lactamase Penicillin-binding protein (PBP) Bacterial	Infection
Zidebactam (WCK-5107) is a potent **β-lactamase inhibitor . Zidebactam also is a penicillin-binding protein2 (PBP2)** inhibitor with an IC₅₀ of 0.26 μg/mL .

HY-B1923

Piperacillin 10+ Cited Publications Pipracil	Antibiotic Bacterial Beta-lactamase Penicillin-binding protein (PBP)	Infection Cancer
Piperacillin is a semisynthetic broad-spectrum *β-lactam* antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins*. Piperacillin is most commonly used in combination with the β-lactamase* inhibitor Tazobactam .

HY-A0256A

Clavulanate potassium 5+ Cited Publications	Beta-lactamase Bacterial Antibiotic	Infection
Clavulanate potassium is a potent *β-lactamase* inhibitor and acts as an antibiotic .

HY-B0555A

Nafcillin sodium monohydrate 2 Publications Verification	Beta-lactamase Bacterial Antibiotic	Infection
Nafcillin sodium monohydrate, an antibiotic, is a reversible inhibitor of *β-lactamase*. Nafcillin sodium monohydrate can be used for the research of staphylococcal infections .

HY-103095

Enmetazobactam 5 Publications Verification AAI101	Beta-lactamase Bacterial	Infection
Enmetazobactam (AAI101) is an extended-spectrum *β-lactamase* inhibitor, against many resistant Gram-negative pathogens .

HY-B0466B

Cloxacillin sodium 3 Publications Verification	Beta-lactamase Bacterial Antibiotic	Infection Inflammation/Immunology Cancer
Cloxacillin sodium is an orally active antibacterial agent and *β-lactamase* inhibitor with an IC₅₀ of 0.04 µM. Cloxacillin sodium can suppress the *S. aureus-induced inflammatory response by inhibiting* the activation of MAPKs, NF-кB and NLRP3-related proteins .

HY-A0256B

Clavulanate lithium 5+ Cited Publications	Beta-lactamase Bacterial Antibiotic	Infection
Clavulanate lithium is a potent *β-lactamase* inhibitor and acts as an antibiotic .

HY-B1286

Piperacillin sodium 10+ Cited Publications Sodium piperacillin	Bacterial Antibiotic Penicillin-binding protein (PBP)	Infection Cancer
Piperacillin sodium is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin is most commonly used in combination with the β-lactamase inhibitor Tazobactam .

HY-B0466

Cloxacillin sodium monohydrate 3 Publications Verification	Beta-lactamase Bacterial Antibiotic	Infection Inflammation/Immunology Cancer
Cloxacillin sodium monohydrate is an orally active antibacterial agent and *β-lactamase* inhibitor with an IC₅₀ of 0.04 µM. Cloxacillin sodium monohydrate can suppress the *S. aureus-induced inflammatory response by inhibiting* the activation of MAPKs, NF-кB and NLRP3-related proteins .

HY-14879

Avibactam free acid Maximum Cited Publications 92 Publications Verification NXL-104 free acid	Beta-lactamase Bacterial Antibiotic	Infection
Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam *β-lactamase* inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively .

HY-147274

Funobactam XNW4107	Beta-lactamase Bacterial	Infection
Funobactam (XNW4107) is a *β-lactamase* inhibitor, can be used for researching anti-bacteria .

HY-14879AR

Avibactam sodium (Standard) NXL-104 (Standard)	Beta-lactamase Reference Standards Bacterial Antibiotic	Infection
Avibactam (sodium) (Standard) is the analytical standard of Avibactam (sodium). This product is intended for research and analytical applications. Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam *β-lactamase* inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively .

HY-147349

Pilabactam sodium ANT3310 sodium	Beta-lactamase Bacterial	Infection
Pilabactam (ANT3310) sodium is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC₅₀ values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). Pilabactam sodium potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam sodium can be used in the research of bacterial infection .

HY-B1434

7-Aminocephalosporanic acid 2 Publications Verification 7-ACA	Beta-lactamase Bacterial Antibiotic	Infection
7-aminocephalosporanic acid (7-ACA) is a HSP90β inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor .

HY-129042

Cibacron Blue 3G-A 1 Publications Verification	Fluorescent Dye Beta-lactamase	Infection
Cibacron Blue 3G-A is an anthraquinone dye, inhibits the R46 *β-lactamase* with a K_i value of 1.2 uM .

HY-132823

Ledaborbactam VNRX-5236	Beta-lactamase Bacterial	Infection
Iedaborbactam (VNRX-5236), as a *β-lactamase* inhibitor (WO2015191907, Example 62), can be used for the research of bacterial infections .

HY-132987

Avibactam tomilopil 2 Publications Verification ARX-1796; AV-006	Beta-lactamase Bacterial Drug Intermediate	Infection
Avibactam tomilopil (ARX-1796, AV-006) is an orally active prodrug of Avibactam and a *β-lactamase* inhibitor. Avibactam tomilopil can be used in the study of diseases such as urinary tract infections .

HY-B1300

Cefonicid sodium	Antibiotic Bacterial Beta-lactamase Interleukin Related	Infection
Cefonicid sodium is a long-acting cephalosporin antibiotic. Cefonicid sodium also acts as a noncompetitive class I *β-lactamase* inhibitor with a K_i value of 0.8 μM. Cefonicid sodium exhibits broad-spectrum antimicrobial activity and is effective against a variety of Gram-positive and Gram-negative bacteria. Cefonicid sodium can be used for research on infections .

HY-14879B

Avibactam sodium hydrate Maximum Cited Publications 92 Publications Verification NXL-104 hydrate	Beta-lactamase Bacterial Antibiotic	Infection
Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam *β-lactamase* inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively .

HY-14879S2

Avibactam sodium salt-13C5 NXL-104-¹³C₅	Isotope-Labeled Compounds Antibiotic Beta-lactamase Bacterial	Infection
Avibactam sodium salt- ¹³C₅ (NXL-104- ¹³C₅) is ¹³C labeled Avibactam (sodium). Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam *β-lactamase* inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively .

HY-108288

Sulbactam pivoxil Pivsulbactam; CP 47904	Beta-lactamase Antibiotic Bacterial	Infection
Sulbactam pivoxil (Pivsulbactam) is a prodrug of Sulbactam (HY-B0334) with oral activity. Sulbactam is a *β-lactamase* inhibitor with antibacterial activity. Sulbactam pivoxil is better absorbed than Sulbactam and results in higher serum levels after oral administration .

HY-136306

Metallo β-lactamase ligand 1	Beta-lactamase Bacterial	Infection
Metallo-beta-lactamase ligand 1 is a class B *β-lactamase* inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A .

HY-108062A

BLI-489 hydrate	Beta-lactamase Bacterial	Infection
BLI-489 hydrate, a penem *β-lactamase* inhibitor, is active against class A and class C as well as some class D β-lactamases. The combination of Piperacillin and BLI-489 hydrate is efficacious against murine infections caused by class A (including extended-spectrum β-lactamases), class C (AmpC), and class D β-lactamase-expressing pathogens .

HY-B0555

Nafcillin	Beta-lactamase Antibiotic Bacterial	Infection
Nafcillin, an antibiotic, is a reversible inhibitor of *β-lactamase*. Nafcillin exhibits bactericidal activity, and can be used for the research of staphylococcal infections .

HY-148790

Pralurbactam FL058	Bacterial Beta-lactamase	Infection
Pralurbactam (FL058) is a β-lactamase (Beta-lactamase) inhibitor. Pralurbactam enhances the antibacterial activity of Imipenem against Mycobacterium abscessus. Pralurbactam reduces the pulmonary bacterial load in neutropenic mice infected with Mycobacterium abscessus. Pralurbactam can be used in research related to infections caused by Mycobacterium abscessus complex, Escherichia coli, and Klebsiella pneumoniae .

HY-B0466A

Cloxacillin	Beta-lactamase Antibiotic Bacterial	Infection Inflammation/Immunology Cancer
Cloxacillin is an orally active antibacterial agent and *β-lactamase* inhibitor with an IC₅₀ of 0.04 µM. Cloxacillin can suppress the *S. aureus-induced inflammatory response by inhibiting* the activation of MAPKs, NF-кB and NLRP3-related proteins .

HY-125604

WCK-4234	Beta-lactamase Bacterial	Infection Inflammation/Immunology
WCK-4234 is a diazabicyclooctane β-lactamase inhibitor and susceptibility restorer. WCK-4234 lacks direct antibacterial activity. WCK-4234 inhibits class A, C, D β-lactamases and extended-spectrum β-lactamases to potentiate Imipenem (HY-B1369A) and Meropenem (HY-13678) activity against Gram-negative pathogens. WCK-4234 can be used for the research of gram-negative bacterial infections and β-lactamase-mediated carbapenem-resistant bacterial infections .

HY-19050

BRL-42715	Beta-lactamase Bacterial	Infection
BRL-42715 is a potent inhibitor of a broad range of bacterial beta-lactamases (β-lactamase) .

HY-119945A

Brobactam sodium	Bacterial Beta-lactamase	Infection
Brobactam sodium is a potent synthetic wide spectrum *β-lactamase* inhibitor. Brobactam sodium has antibacterial activity .

HY-132824

Ledaborbactam etzadroxil VNRX-7145	Beta-lactamase Bacterial	Infection
Ledaborbactam etzadroxil (VNRX-7145) is an orally active *Ambler class A, C, and D β-lactamase* enzymes** inhibitor .

HY-139744

FPI-1465	Beta-lactamase Penicillin-binding protein (PBP) Bacterial	Infection
FPI-1465 acts a dual inhibitor of *serine-β-Lactamases* and Penicillin-binding proteins (PBPs).FPI-1465 inhibits PBP2 (IC₅₀=1.0 µg/mL). FPI-1465 exhibits activity against β-lactamase CTX-M-15 and OXA-48 with K_ds of 0.011 and 5.3 µM, respectively .

HY-139745

FPI-1523 sodium	Beta-lactamase Bacterial	Infection
FPI-1523 sodium, a derivative of Avibactam, is a potent *β-lactamase* inhibitor, with K_ds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 sodium also inhibits PBP2, with an IC₅₀ of 3.2 μM. FPI-1523 sodium exhibits considerable antimicrobial activity .

HY-19773

β-Lactamase-IN-1	Beta-lactamase Bacterial	Infection
β-Lactamase-IN-1 is an inhibitor of *β-Lactamase* extracted from patent WO2016027249A1, page 77. β-Lactamase-IN-1 can be used to prepare of tricyclic nitrogen containing compound. β-Lactamase-IN-1 can be used for the research of neisseria gonorrhea infection .

HY-B0555B

Nafcillin sodium	Beta-lactamase Antibiotic Bacterial	Infection
Nafcillin sodium, an antibiotic, is a reversible inhibitor of *β-lactamase*. Nafcillin sodium can be used for the research of staphylococcal infections .

HY-125356

ETX0282	Beta-lactamase	Infection
ETX0282 is an orally active prodrug, with its active form being ETX1317. ETX0282 and ETX1317 are *β-lactamase* inhibitors of the dioxolane-dibenzo-p-heptane (DBO) type. ETX0282 exhibits high stability during intestinal absorption and can be efficiently converted into ETX1317 in the liver. ETX0282 alone has no bactericidal activity, but in a mouse model of neutropenic thigh infection, it can significantly reduce bacterial load when used in combination with Cefpodoxime Proxetil (HY-N7101). ETX0282 can be used for the study of infections caused by drug-resistant Gram-negative bacteria .

HY-147349A

Pilabactam ANT3310	Bacterial Beta-lactamase	Infection
Pilabactam (ANT3310) is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC₅₀ values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). Pilabactam potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam can be used in the research of bacterial infection .

HY-B0555BS

Nafcillin-d5 sodium	Isotope-Labeled Compounds Beta-lactamase Antibiotic	Infection
Nafcillin-d₅ (sodium) is the deuterium labeled Nafcillin sodium. Nafcillin sodium, an antibiotic, is a reversible inhibitor of β-lactamase. Nafcillin sodium can be used for the research of staphylococcal infections .

HY-120859A

Zidebactam sodium salt WCK-5107 sodium salt	Beta-lactamase Penicillin-binding protein (PBP) Bacterial	Infection
Zidebactam sodium salt (WCK-5107 sodium salt) is a potent **β-lactamase inhibitor . Zidebactam also is a penicillin-binding protein2 (PBP2)** inhibitor with an IC₅₀ of 0.26 μg/mL .

HY-146637

VIM-2-IN-1	Beta-lactamase Bacterial	Infection
VIM-2-IN-1 (compound 1dj) is a *β-lactamase* inhibitor with antibacterial activities. VIM-2-IN-1 has moderate IC₅₀ values of 23 µM, 48 µM and 231 µM for *Verona integron-encoded metallo-β-lactamase* (VIM-2), German imipenemase-1 (GIM-1) and New Delhi metallo-β-lactamase (NDM-1)**, respectively .

HY-U00380

Tigemonam	Antibiotic Beta-lactamase Bacterial	Infection
Tigemonam is an orally active monobactam antibiotic with a K_i of 0.86 μM against Enterobacter cloacae P99 β-lactamase and 50.8 μM against Escherichia coli TEM-1 β-lactamase. Tigemonam binds to penicillin-binding proteins 1a, 3, and 4, inhibits bacterial cell wall synthesis, and exhibits bactericidal activity against aerobic gram-negative bacteria including Enterobacteriaceae, Haemophilus influenzae, and Neisseria gonorrhoeae. Tigemonam resists hydrolysis by multiple β-lactamase enzymes, reduces bacterial load in systemic, pyelonephritic, lung, and thigh muscle infections in rodents, and shows minimal difference between minimum inhibitory and bactericidal concentrations. Tigemonam can be used for the research of gram-negative bacterial infections, acute pyelonephritis, lung infection, and thigh muscle infection .

HY-108062

BLI-489	Beta-lactamase Bacterial	Infection
BLI-489 is a *beta-lactamase* inhibitor. BLI-489 combined with Piperacillin (HY-B1923) inhibits infection caused by class A (including ultra-broad spectrum β-lactamase), Class C (AmpC) and Class D β-lactamase expressing pathogens .

HY-14879BR

Avibactam sodium hydrate (Standard) NXL-104 hydrate (Standard)	Beta-lactamase Reference Standards Bacterial Antibiotic	Infection
Avibactam (sodium hydrate) (Standard) is the analytical standard of Avibactam (sodium hydrate). This product is intended for research and analytical applications. Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1].

HY-139699

GT-055 LCB18-055	Beta-lactamase	Infection
GT-055 (LCB18-055) is a novel broad-spectrum *β-lactamase* inhibitor.

HY-W588257

(+)-Thienamycin	Bacterial Beta-lactamase	Infection Inflammation/Immunology
(+)-Thienamycin is a potent broad-spectrum antibacterial and β-lactamase inhibitor that can be from Streptomyces cattleya .

HY-122699

LN-1-255 sodium	Beta-lactamase Bacterial	Infection
LN-1-255 sodium is a β-lactamase inhibitor. LN-1-255 sodium has broad-spectrum inhibitory effect on type D carbapenemases (CHDLs) with an IC₅₀ for OXA-48 of 3 nM, and it also has strong activity against OXA-23, OXA-24/40, etc. LN-1-255 sodium combined with carbapenem antibiotics has a synergistic effect. LN-1-255 sodium can be used to study the bacterial resistance crisis caused by CHDLs .

HY-154438

RDR 02308	Beta-lactamase Toll-like Receptor (TLR) Bacterial	Inflammation/Immunology
RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length *β-lactamase* .

HY-136071

Xeruborbactam methoxy acetoxy methy ester	Beta-lactamase Bacterial	Infection
Xeruborbactam methoxy acetoxy methy ester is a boronic acid *β-lactamase* inhibitor, exacted from WO2018005662A1, compound 43 .

Cat. No.	Product Name	Type

HY-129042

Cibacron Blue 3G-A 1 Publications Verification	Fluorescent Dyes
Cibacron Blue 3G-A is an anthraquinone dye, inhibits the R46 *β-lactamase* with a K_i value of 1.2 uM .

HY-13271AG

Tubastatin A

Fluorescent Dyes

Tubastatin A (GMP) is the Tubastatin A (HY-13271A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Tubastatin A is a potent and selective HDAC6 inhibitor with an IC₅₀ of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A also inhibits HDAC10 and metallo-β-lactamase domain-containing protein 2 (MBLAC2).

Cat. No.	Product Name	Type

HY-13271AG

Tubastatin A

Biochemical Assay Reagents

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1418

Tazobactam 15+ Cited Publications CL-298741; YTR-830H	Infection Microorganisms Anti-inflammation/Immunoregulatory Classification of Application Fields Antibiotics Resistance Selection Antibacterial Disease Research Disease Research Fields Beta-lactam Antibiotics Source Classification	Beta-lactamase Antibiotic Bacterial
Tazobactam (CL-298741) is a potent *β-lactamases* inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research .

HY-B1434

7-Aminocephalosporanic acid 2 Publications Verification 7-ACA	Infection Classification of Application Fields Disease Research Fields	Beta-lactamase Bacterial Antibiotic
7-aminocephalosporanic acid (7-ACA) is a HSP90β inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor .

HY-121765

Dacisteine N,S-Diacetyl-L-cysteine	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Dacisteine (N,S-Diacetyl-L-cysteine) is a cysteine derivative and displays a less *New Delhi metallo-beta-lactamase-1 (NDM-1)* inhibitor with an IC₅₀ value of 1000 μM . Dacisteine can be used for the treatment of cardiovascular and cerebrovascular diseases caused by platelet aggregation .

HY-N7111

Sultamicillin tosylate Sultamicillin (tosilate)	Infection Classification of Application Fields Disease Research Fields	Bacterial Antibiotic
Sultamicillin tosylate is a broad-spectrum and orally active *beta-lactamase* inhibitor, an antibiotic with antibacterial activity .

HY-N6736

K-252c	Infection Alkaloids Microorganisms Classification of Application Fields Disease Research Fields Indole Alkaloids Source Classification	Beta-lactamase PKC Bacterial Apoptosis
K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC₅₀ of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase .

HY-B1418R

Tazobactam (Standard) CL-298741 (Standard); YTR-830H (Standard)	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Antibiotics Resistance Selection Antibacterial Disease Research Beta-lactam Antibiotics Source Classification	Beta-lactamase Reference Standards Antibiotic Bacterial
Tazobactam (Standard) is the analytical standard of Tazobactam. This product is intended for research and analytical applications. Tazobactam (CL-298741) is a potent *β-lactamases* inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research .

HY-105751

Kalafungin Kalamycin; U-19718	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial Beta-lactamase Fungal
Kalafungin is an antibiotic, antimicrobial agent and a *β-lactamase* inhibitor from marine Streptomyces, with IC₅₀ of 225.37 μM. Kalafungin destroys cell membranes. Kalafungin shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria (such as S. aureus ATCC 33591 and S. aureus ATCC 23591), and, to a lesser extent, gram-negative bacteria .

HY-N14919

Olivanic acid	Structural Classification Microorganisms Antibiotics Beta-lactam Antibiotics Source Classification	Beta-lactamase Antibiotic Bacterial
Olivanic acid is a β -lactam antibiotic. Olivanic acid has the effect of anti -Gram-positive bacteria and anti-Gram-negative bacteria. Olivanic acid inhibits β-lactamase .

HY-N14693

Pluracidomycin B	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic Bacterial
Pluracidomycin B is a carbapenem antibiotic. Pluracidomycin B has anti-Gram-positive bacteria and Gram-negative bacteria activity, and has the effect of inhibiting β-lactamase .

HY-N14694

Pluracidomycin C1	Structural Classification Microorganisms Antibiotics Beta-lactam Antibiotics Source Classification	Antibiotic Bacterial
Pluracidomycin C1 is a carbapenem antibiotic. Pluracidomycin C1 has anti-Gram-positive bacteria and Gram-negative bacteria activity, and has the effect of inhibiting β-lactamase .

HY-N14692

Pluracidomycin A1	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic Bacterial
Pluracidomycin A1 is a carbapenem antibiotic . Pluracidomycin A1 has anti-Gram-positive bacteria and Gram-negative bacteria activity, and has the effect of inhibiting β-lactamase .

HY-W015786R

4-Ethoxyphenol (Standard)	Structural Classification Monophenols Phenols Endogenous metabolite Source Classification	Reference Standards Bacterial
L-Amoxicillin (Standard) is the analytical standard of L-Amoxicillin. This product is intended for research and analytical applications. L-Amoxicillin is an antibiotic with activity against a wide range of bacterial infections. L-Amoxicillin is commonly used in antibacterial combinations when used in combination with the β-lactamase inhibitor potassium clavulanic acid. The related substances analysis method for L-Amoxicillin has been developed and validated according to the International Conference on Harmonization (ICH) guidelines, ensuring its effectiveness and accuracy in mixtures. L-Amoxicillin and some of its impurities have been further analyzed in stress testing and stability studies, providing support for optimizing its application .

HY-121765R

Dacisteine (Standard) N,S-Diacetyl-L-cysteine (Standard)	Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Dacisteine (Standard) is the analytical standard of Dacisteine. This product is intended for research and analytical applications. Dacisteine (N,S-Diacetyl-L-cysteine) is a cysteine derivative and displays a less *New Delhi metallo-beta-lactamase-1 (NDM-1)* inhibitor with an IC₅₀ value of 1000 μM . Dacisteine can be used for the treatment of cardiovascular and cerebrovascular diseases caused by platelet aggregation .

Cat. No.	Product Name	Chemical Structure

HY-14879S2

Avibactam sodium salt-13C5
Avibactam sodium salt- ¹³C₅ (NXL-104- ¹³C₅) is ¹³C labeled Avibactam (sodium). Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam *β-lactamase* inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively .

HY-143831S

Cefepime-d8 sulfate

Cefepime-d₈ (BMY-28142-d₈) sulfate is deuterium labeled Cefepime sulfate. Cefepime sulfate is a broad-spectrum, blood-brain barrier-permeable cephalosporin antibiotic with hPON1 inhibitory activity, with an IC₅₀ of 21.115 mM and a K_i of 35.092 mM. Cefepime sulfate inhibits hPON1 via a non-competitive mechanism and blocks GABA_A receptors. Cefepime sulfate penetrates the outer membrane of Gram-negative bacteria, inhibits the growth of Gram-positive and Gram-negative bacteria, and does not induce the production of β-lactamase.

HY-W654023

Tazobactam-15N3 sodium
Tazobactam- ¹⁵N₃ sodium is the ¹⁵N labeled isotope of Tazobactam sodium (HY-W009168) . Tazobactam sodium is an antibiotic of the beta-lactamase inhibitor class.

HY-W654100

Cefepime-d3 sulfate

Cefepime-d₃ (BMY-28142-d₃) sulfate is deuterium labeled Cefepime sulfate. Cefepime sulfate is a broad-spectrum, blood-brain barrier-permeable cephalosporin antibiotic with hPON1 inhibitory activity, with an IC₅₀ of 21.115 mM and a K_i of 35.092 mM. Cefepime sulfate inhibits hPON1 via a non-competitive mechanism and blocks GABA_A receptors. Cefepime sulfate penetrates the outer membrane of Gram-negative bacteria, inhibits the growth of Gram-positive and Gram-negative bacteria, and does not induce the production of β-lactamase.

HY-B0555BS

Nafcillin-d5 sodium
Nafcillin-d₅ (sodium) is the deuterium labeled Nafcillin sodium. Nafcillin sodium, an antibiotic, is a reversible inhibitor of β-lactamase. Nafcillin sodium can be used for the research of staphylococcal infections .

HY-B0334AS

Sulbactam-d5 sodium
Sulbactam-d₅ (sodium) is the deuterium labeled Sulbactam sodium. Sulbactam (CP45899) sodium is a competitive, irreversible beta-lactamase inhibitor. Sulbactam sodium shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex .

HY-B0334AS1

Sulbactam-d2 sodium
Sulbactam-d₂ (sodium) is the deuterium labeled Sulbactam sodium . Sulbactam (CP45899) sodium is a competitive, irreversible beta-lactamase inhibitor. Sulbactam sodium shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex .

HY-B0334S

Sulbactam-d3
Sulbactam-d₃ (CP45899-d₃) is deuterium labeled Sulbactam. Sulbactam (CP45899) is a competitive, irreversible *beta-lactamase* inhibitor. Sulbactam shows antimicrobial activity against multidrug-resistant (MDR) acinetobacter calcoaceticus--Acinetobacter baumannii (Acb) complex .

HY-B1418S2

Tazobactam-15N,d2
Tazobactam- ¹⁵N,d₂ (CL-298741- ¹⁵N,d₂) is ¹⁵N and deuterium labeled Tazobactam. Tazobactam (CL-298741) is a potent *β-lactamases* inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research .

HY-16752S1

Relebactam-d9
Relebactam-d₉ (MK-7655-d₉) is deuterium labeled Relebactam. Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of *β-lactamases, including class A (extended-spectrum β-lactamases* and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity .

HY-W743258

L-Amoxicillin-d4 sodium

L-Amoxicillin-d₄ sodium is the deuterium labeled L-Amoxicillin (HY-129836). L-Amoxicillin is an antibiotic with activity against a wide range of bacterial infections. L-Amoxicillin is commonly used in antibacterial combinations when used in combination with the β-lactamase inhibitor potassium clavulanic acid. The related substances analysis method for L-Amoxicillin has been developed and validated according to the International Conference on Harmonization (ICH) guidelines, ensuring its effectiveness and accuracy in mixtures. L-Amoxicillin and some of its impurities have been further analyzed in stress testing and stability studies, providing support for optimizing its application .

HY-B0368S

Captopril-d3

Captopril-d₃ is deuterium labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

HY-B0368S1

Captopril-13C5,15N

Captopril- ¹³C₅, ¹⁵N (SQ 14225- ¹³C₅, ¹⁵N) is ¹³C and ¹⁵N labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

HY-14879S7

Avibactam-13C5,15N sodium
Avibactam- ¹³C₅,15N sodium (NXL-104- ¹³C₅, ¹⁵N sodium) is the ¹³C- and ¹⁵N-labeled Avibactam (HY-14879). Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC₅₀s of 8 nM and 5 nM, respectively .

Targets Recommended: Beta-lactamase Serpin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13271AG

Tubastatin A	HDAC Beta-lactamase Autophagy Apoptosis	Cancer
Tubastatin A (GMP) is the Tubastatin A (HY-13271A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Tubastatin A is a potent and selective HDAC6 inhibitor with an IC₅₀ of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A also inhibits HDAC10 and *metallo-β-lactamase* domain-containing protein 2 (MBLAC2)**.

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