1. Anti-infection
  2. Beta-lactamase Bacterial Antibiotic
  3. 7-Aminocephalosporanic acid

7-Aminocephalosporanic acid  (Synonyms: 7-ACA)

Cat. No.: HY-B1434 Purity: ≥98.0%
COA Handling Instructions

7-aminocephalosporanic acid (7-ACA) is a HSP90β inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor.

For research use only. We do not sell to patients.

7-Aminocephalosporanic acid Chemical Structure

7-Aminocephalosporanic acid Chemical Structure

CAS No. : 957-68-6

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Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE 7-Aminocephalosporanic acid

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

7-aminocephalosporanic acid (7-ACA) is a HSP90β inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor[1][2].

IC50 & Target

β-lactam

 

In Vitro

7-Aminocephalosporanic acid (0-160 μM, 24 h) reduces cellular total cholesterol (TC) and triglyceride (TG) in HepG2 cells by decreasing sterol regulatory element-binding proteins (SREBPs)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

7-Aminocephalosporanic acid (5-25 mg/kg, i.p., every 2 days for 12 weeks) reduces lipid accumulation in HFD-induced obese mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HFD-induced obese mice[2]
Dosage: 5-25 mg/kg
Administration: i.p., every 2 days for 12 weeks.
Result: Improved glucose tolerance and insulin sensitivity.
Decreased TC and TG in serum.
Inhibited liver steatosis.
Decreased the protein expression levels of hepatic SREBP-1 and SREBP-2.
Molecular Weight

272.28

Formula

C10H12N2O5S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(N12)=C(COC(C)=O)CS[C@]2([H])[C@H](N)C1=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 1.1 mg/mL (4.04 mM; ultrasonic and adjust pH to 14 with NaOH)

Ethanol : 1.1 mg/mL (4.04 mM; Need ultrasonic)

DMF : < 1 mg/mL (insoluble)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6727 mL 18.3634 mL 36.7269 mL
5 mM --- --- ---
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 1 mg/mL (3.67 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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7-Aminocephalosporanic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
7-Aminocephalosporanic acid
Cat. No.:
HY-B1434
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