7-Aminocephalosporanic acid
Based on 2 publication(s) in Google Scholar
7-aminocephalosporanic acid (7-ACA) is a HSP90β inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor.
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- Pureté: 98.0%
- CAS No.: 957-68-6
- Formule: C10H12N2O5S
- Masse moléculaire:272.28
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 7-Aminocephalosporanic acid
MoreVoir tous les produits spécifiques à Isoform Beta-lactamase
MoreVoir tous les produits spécifiques à Isoform Antibiotic
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Activité biologique
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β-lactam |
7-Aminocephalosporanic acid (0-160 μM, 24 h) reduces cellular total cholesterol (TC) and triglyceride (TG) in HepG2 cells by decreasing sterol regulatory element-binding proteins (SREBPs)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HFD-induced obese mice[2]
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Dosage:5-25 mg/kg
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Administration:i.p., every 2 days for 12 weeks.
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Result:Improved glucose tolerance and insulin sensitivity.
Decreased TC and TG in serum.
Inhibited liver steatosis.
Decreased the protein expression levels of hepatic SREBP-1 and SREBP-2.
Chemical Information
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CAS No. 957-68-6
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Appearance Solid
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Masse moléculaire 272.28
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Formule C10H12N2O5S
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Color White to off-white
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SMILES
O=C(C(N12)=C(COC(C)=O)CS[C@]2([H])[C@H](N)C1=O)O
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Synonyms
7-ACA
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Signal
The FMO3/TMAO/HSP90β axis aggravates MAFLD by disrupting mitochondrial protein homeostasis. [Abstract]2025 Oct:134:111960. PMID: 40562261 -
Biochem Biophys Res Commun
7-aminocephalosporanic acid, a novel HSP90β inhibitor, attenuates HFD-induced hepatic steatosis. [Abstract]2022 Sep 24:622:184-191. PMID: 35932530
Solvant et solubilité
H2O : 1.1 mg/mL (4.04 mM; ultrasonic and adjust pH to 14 with NaOH)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 1 mg/mL (3.67 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Pureté et documentation
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Fiche technique (276 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Ding JM, et al. Identification and Characterization of a New 7-Aminocephalosporanic Acid Deacetylase from Thermophilic Bacterium Alicyclobacillus tengchongensis. J Bacteriol. 2015 Nov 2;198(2):311-20. [Content Brief]
[2]. Zhang W, et al. 7-aminocephalosporanic acid, a novel HSP90β inhibitor, attenuates HFD-induced hepatic steatosis. Biochem Biophys Res Commun. 2022 Sep 24;622:184-191. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.6727 mL | 18.3634 mL | 36.7269 mL | 91.8172 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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