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  2. Bacterial
  3. BLI-489 hydrate

BLI-489 hydrate 

Cat. No.: HY-108062A
Handling Instructions

BLI-489 hydrate, a penem β-lactamase inhibitor, is active against class A and class C as well as some class D β-lactamases. The combination of Piperacillin and BLI-489 hydrate is efficacious against murine infections caused by class A (including extended-spectrum β-lactamases), class C (AmpC), and class D β-lactamase-expressing pathogens.

For research use only. We do not sell to patients.

BLI-489 hydrate Chemical Structure

BLI-489 hydrate Chemical Structure

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Description

BLI-489 hydrate, a penem β-lactamase inhibitor, is active against class A and class C as well as some class D β-lactamases. The combination of Piperacillin and BLI-489 hydrate is efficacious against murine infections caused by class A (including extended-spectrum β-lactamases), class C (AmpC), and class D β-lactamase-expressing pathogens[1][2].

In Vivo

On the basis of preliminary results with various ratios, a dosing ratio of 8:1 was found to be optimal for retention of enhanced efficacy. Piperacillin-BLI-489 dosed at an 8:1 ratio was efficacious against murine infections caused by class A (including extended-spectrum beta-lactamases), class C (AmpC), and class D beta-lactamase-expressing pathogens[2].

Formula

C₁₃H₁₂N₃NaO₅S.xH₂O

SMILES

O=C(C1=CS[[email protected]@](/C2=C/C3=CN4C(COCC4)=N3)([H])N1C2=O)O[Na].[x].O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BLI-489BLI489BLI 489BacterialInhibitorinhibitorinhibit

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Product name:
BLI-489 hydrate
Cat. No.:
HY-108062A
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