Efficacy of piperacillin combined with the Penem beta-lactamase inhibitor BLI-489 in murine models of systemic infection

  • Antimicrob Agents Chemother. 2009 Apr;53(4):1698-700. doi: 10.1128/AAC.01549-08.
Peter J Petersen  1 ,  C Hal Jones ,  Aranapakam M Venkatesan ,  Patricia A Bradford
Affiliations
  • 1. Infectious Disease Research, Wyeth Research, Pearl River, NY 10965, USA. [email protected]
PMID: 19188386 DOI: 10.1128/AAC.01549-08
Abstract

The in vivo efficacy of piperacillin in combination with the penem inhibitor BLI-489 was determined using acute lethal systemic infections in mice. On the basis of preliminary results with various ratios, a dosing ratio of 8:1 was found to be optimal for retention of enhanced efficacy. Piperacillin-BLI-489 dosed at an 8:1 ratio was efficacious against murine infections caused by class A (including extended-spectrum beta-lactamases), class C (AmpC), and class D beta-lactamase-expressing pathogens.

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