1. Epigenetics
    TGF-beta/Smad
    Anti-infection
    Apoptosis
  2. PKC
    Bacterial
    Apoptosis
  3. K-252c

K-252c 

Cat. No.: HY-N6736
Handling Instructions

K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase.

For research use only. We do not sell to patients.

K-252c Chemical Structure

K-252c Chemical Structure

CAS No. : 85753-43-1

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Description

K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase[1][2][3].

IC50 & Target

IC50: 2.45 µM (PKC)[1].

Molecular Weight

311.34

Formula

C₂₀H₁₃N₃O

CAS No.

85753-43-1

SMILES

O=C1NCC2=C1C3=C(C4=C2C5=C(N4)C=CC=C5)NC6=C3C=CC=C6

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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K-252c
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