2. Epigenetics TGF-beta/Smad Anti-infection Apoptosis
  3. Beta-lactamase PKC Bacterial Apoptosis
  4. K-252c

K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase.

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K-252c Chemical Structure

K-252c Chemical Structure

CAS No. : 85753-43-1

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Based on 1 publication(s) in Google Scholar

K-252c Related Antibodies

Top Publications Citing Use of Products

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Metallo-β-lactamase

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

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Description

K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase[1][2][3].

IC50 & Target

IC50: 2.45 µM (PKC)[1].
Molecular Weight

311.34

Formula

C20H13N3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NCC2=C1C3=C(C4=C2C5=C(N4)C=CC=C5)NC6=C3C=CC=C6
Structure Classification
Initial Source

Nocardiopsis sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: ≥99.0%

COA (258 KB)

Handling Instructions (2659 KB)
References
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K-252c Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K-252c85753-43-1Beta-lactamasePKCBacterialApoptosisβ-lactamaseProtein kinase CInhibitorinhibitorinhibit

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