CB-618
CB-618 is a β-lactamase inhibitor. CB-618 reversibly covalently inhibits Ambler class A, C, and some class D serine β-lactamases. CB-618 has weak antibacterial activity as a single agent, but it significantly enhances the antibacterial activity of Meropenem (HY-13678) against enzyme-producing Enterobacteriaceae. CB-618 can be used in research on drug-resistant bacteria.
For research use only. We do not sell to patients.
- CAS No.: 1463520-70-8
- Formula: C8H10N4O6S
- Molecular Weight:290.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Beta-lactamase Isoforms
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Biological Activity
Chemical Information
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CAS No. 1463520-70-8
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Molecular Weight 290.25
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Formula C8H10N4O6S
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SMILES
O=S(ON1[C@]2([H])CC[C@@H](C3=NN=CO3)[N@@](C2)C1=O)(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Papp-Wallace KM, Bonomo RA. New β-lactamase inhibitors in the clinic. Infectious disease clinics of North America. 2016 Jun;30(2):441. [Content Brief]
[2]. Griffith DC, et al. Pharmacokinetics/pharmacodynamics of vaborbactam, a novel beta-lactamase inhibitor, in combination with meropenem. Antimicrobial Agents and Chemotherapy. 2019 Jan;63(1):10-128. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CB-618 Related Classifications
HY-120235 Related Classifications
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