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Tubastatin A TFA

(Synonyms: TSA TFA)
42 Cited Publications
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Based on 42 publication(s) in Google Scholar

Tubastatin A (TSA) TFA is a potent and selective?HDAC6?inhibitor with?IC50?of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A TFA also inhibits HDAC10 and metallo-β-lactamase domain-containing protein?2 (MBLAC2).

For research use only. We do not sell to patients.

  • CAS No.: 1239262-52-2
  • Formula: C22H22F3N3O4
  • Molecular Weight:449.42
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Tubastatin A TFA Chemical Structure
    Tubastatin A TFA Chemical Structure
  • Experimental Validation Results for Tubastatin A TFA
  • Experimental Validation Results for Tubastatin A TFA
  • Experimental Validation Results for Tubastatin A TFA
  • Experimental Validation Results for Tubastatin A TFA
  • Experimental Validation Results for Tubastatin A TFA
  • Experimental Validation Results for Tubastatin A TFA
  • Experimental Validation Results for Tubastatin A TFA
  • Experimental Validation Results for Tubastatin A TFA
  • Experimental Validation Results for Tubastatin A TFA
CAS No.: 1239262-52-2
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  • Tubastatin A TFA Chemical Structure
    Tubastatin A TFA Chemical Structure
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    Tubastatin A TFA purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2025 Jan;15(1):e70193. [Abstract]

    Customer Validation
     The inhibition of HDAC6 restored the spindle assembly caused by TUBB8 missense variants. Representative confocal images showed spindle morphology in groups of WT, D417N (DMSO), D417N + tubacin (2 μM), and D417N + Tubastatin A (10 μM; DMSO).

  • 1/16

    Tubastatin A TFA purchased from MedChemExpress. Usage Cited in: Neurotherapeutics. 2023 Jul;20(4):1215-1228. [Abstract]

    Customer Validation
     Tubastatin A (TubA) (1 μM; overnight) treatment restores mitochondrial transport in cultured Gan−/− DRG neurons. Graph represents the significant increase in the total movement of mitochondria in Tubastatin A (TubA)-treated Gan−/− DRG neurons.

  • 1/16

    Tubastatin A TFA purchased from MedChemExpress. Usage Cited in: Neurotherapeutics. 2023 Jul;20(4):1215-1228. [Abstract]

    Customer Validation
     Tubastatin A (TubA) (1 μM; overnight) treatment increased levels of acetylated tubulin and Prph in the sciatic nerve of Gan−/−;TgPer mice. The figure represented the western blots for Nefl, Prph, acetyl tubulin, and α-tubulin, respectively, from the sciatic nerve of saline- and Tubastatin A (TubA)-treated mice.

  • 1/16

    Tubastatin A TFA purchased from MedChemExpress. Usage Cited in: Neurotherapeutics. 2023 Jul;20(4):1215-1228. [Abstract]

    Customer Validation
     Immunostaining of Nefl and Prph was performed on the cell body area of spinal neurons (larger than 250 μm²) from saline- and Tubastatin A (TubA)-treated mice, followed by quantification of the signal intensity. There was a significant decrease in the signal intensity for Nefl and Prph proteins in the perikaryon of spinal neurons from Gan−/−;TgPer mice treated with Tubastatin A (TubA) when compared to saline-treated Gan−/−;TgPer mice.

  • 1/16

    Tubastatin A TFA purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2022 Oct;12(10):3891-3904. [Abstract]

    Customer Validation
     The baseline and blocking time-activity curves of PB118 in the mice whole brain. Compared with baseline mice, remarkably reduced radioactivity was observed in the brain of mice pretreated with Tubastatin A (3.0 mg/kg; 5 min before RI).

  • 1/16

    Tubastatin A TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Oct 21;13(10):888. [Abstract]

    Customer Validation
     Construction of HCT116 cell line with stable HDAC6 knockdown. Tubastatin A HCl is HDAC6 selective inhibitor.

  • 1/16

    Tubastatin A TFA purchased from MedChemExpress. Usage Cited in: J Nutr. 2020 Jul 1;150(7):1790-1798. [Abstract]

    Customer Validation
     Effects of TBSA (Tubastatin A) pretreatment on glucose-induced changes in mRNA amounts of genes in IECs of yellow catfish.

  • 1/16

    Tubastatin A TFA purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Feb 1:9:34. [Abstract]

    Customer Validation
     HDAC6 inhibition with Tubastatin A acetylates TFEB, facilitates TFEB nuclear translocation and attenuates programmed cell death in NRK-52E cells. Immunoblotting for acetylated α-tubulin in NRK-52E cells treated with Tubastatin A.

  • 1/16

    Tubastatin A TFA purchased from MedChemExpress. Usage Cited in: University of Toronto. 2017 Nov.

    Customer Validation
     Tubastatin A induces a dose-dependent increase in acetylated α-tubulin levels in NRK-52E cells.

  • Tubastatin A TFA