WCK-4234 free base
WCK-4234 free base is a diazabicyclooctane β-lactamase inhibitor and susceptibility restorer. WCK-4234 free base lacks direct antibacterial activity. WCK-4234 free base inhibits class A, C, D β-lactamases and extended-spectrum β-lactamases to potentiate Imipenem (HY-B1369A) and Meropenem (HY-13678) activity against Gram-negative pathogens. WCK-4234 free base can be used for the research of gram-negative bacterial infections and β-lactamase-mediated carbapenem-resistant bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 1706523-58-1
- Formula: C7H9N3O5S
- Molecular Weight:247.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Beta-lactamase Isoforms
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Biological Activity
WCK-4234 (4-8 mg/L) free base potently potentiates imipenem and meropenem against clinical Enterobacteriaceae isolates with KPC, OXA-48, or OXA-181 carbapenemases, or combinations of AmpC/ESBL activity and impermeability, reducing geometric mean carbapenem MICs to ≤1 mg/L, but does not potentiate carbapenems against MBL-producing Enterobacteriaceae[2].
WCK-4234 (4-8 mg/L) free base potentiates imipenem and meropenem against AmpC-hyperproducing, OprD-deficient, and OXA-181-producing Pseudomonas aeruginosa isolates, reducing carbapenem MIC50s by 4-fold or more, but does not potentiate carbapenems against MBL-producing Pseudomonas aeruginosa[2].
WCK-4234 (4-8 mg/L) free base potently potentiates imipenem and meropenem against OXA-23-producing and hyperproduced OXA-51-producing Acinetobacter baumannii isolates, reducing geometric mean carbapenem MIC50s by 8-40-fold to ≤2 mg/L in most cases, but does not potentiate carbapenems against MBL-producing Acinetobacter baumannii[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1706523-58-1
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Molecular Weight 247.23
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Formula C7H9N3O5S
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SMILES
O=S(ON1[C@@]2([H])C[N@]([C@@H](CC2)C#N)C1=O)(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Iregui A, et al. Activity of Meropenem with a Novel Broader-Spectrum β-Lactamase Inhibitor, WCK 4234, against Gram-Negative Pathogens Endemic to New York City. Antimicrob Agents Chemother. 2019;64(1):e01666-19. Published 2019 Dec 20. [Content Brief]
[2]. Mushtaq S, et al. WCK 4234, a novel diazabicyclooctane potentiating carbapenems against Enterobacteriaceae, Pseudomonas and Acinetobacter with class A, C and D β-lactamases. J Antimicrob Chemother. 2017 Jun 1;72(6):1688-1695. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WCK-4234 free base Related Classifications
HY-125604A Related Classifications
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- WCK-4234
- 1706523-58-1
- WCK4234
- WCK 4234
- Beta-lactamase
- Bacterial
- Pseudomonas aeruginosa
- extended-spectrum β-lactamases
- Gram-negative pathogens
- carbapenem-resistant bacterial infections
- Enterobacteriaceae
- β-lactamase inhibitor
- Acinetobacter baumannii
- class A β-lactamases
- class D β-lactamases
- class C β-lactamases
- Inhibitor
- inhibitor
- inhibit