WCK-4234 free base 

WCK-4234 free base is a diazabicyclooctane β-lactamase inhibitor and susceptibility restorer. WCK-4234 free base lacks direct antibacterial activity. WCK-4234 free base inhibits class A, C, D β-lactamases and extended-spectrum β-lactamases to potentiate Imipenem (HY-B1369A) and Meropenem (HY-13678) activity against Gram-negative pathogens. WCK-4234 free base can be used for the research of gram-negative bacterial infections and β-lactamase-mediated carbapenem-resistant bacterial infections^[1][2].

WCK-4234 (4-8 mg/L) free base potently potentiates imipenem and meropenem against clinical Enterobacteriaceae isolates with KPC, OXA-48, or OXA-181 carbapenemases, or combinations of AmpC/ESBL activity and impermeability, reducing geometric mean carbapenem MICs to ≤1 mg/L, but does not potentiate carbapenems against MBL-producing Enterobacteriaceae^[2].
WCK-4234 (4-8 mg/L) free base potentiates imipenem and meropenem against AmpC-hyperproducing, OprD-deficient, and OXA-181-producing Pseudomonas aeruginosa isolates, reducing carbapenem MIC₅₀s by 4-fold or more, but does not potentiate carbapenems against MBL-producing Pseudomonas aeruginosa^[2].
WCK-4234 (4-8 mg/L) free base potently potentiates imipenem and meropenem against OXA-23-producing and hyperproduced OXA-51-producing Acinetobacter baumannii isolates, reducing geometric mean carbapenem MIC₅₀s by 8-40-fold to ≤2 mg/L in most cases, but does not potentiate carbapenems against MBL-producing Acinetobacter baumannii^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

247.23

C₇H₉N₃O₅S

1706523-58-1

O=S(ON1[C@@]2([H])C[N@]([C@@H](CC2)C#N)C1=O)(O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Iregui A, et al. Activity of Meropenem with a Novel Broader-Spectrum β-Lactamase Inhibitor, WCK 4234, against Gram-Negative Pathogens Endemic to New York City. Antimicrob Agents Chemother. 2019;64(1):e01666-19. Published 2019 Dec 20.  [Content Brief]

  [2]. Mushtaq S, et al. WCK 4234, a novel diazabicyclooctane potentiating carbapenems against Enterobacteriaceae, Pseudomonas and Acinetobacter with class A, C and D β-lactamases. J Antimicrob Chemother. 2017 Jun 1;72(6):1688-1695.  [Content Brief]