Carumonam  (Synonyms: AMA-1080; Ro 17-2301)

Carumonam (AMA-1080; Ro 17-2301) is a sulfonated monocyclic β-Lactam Antibiotic, targeting to penicillin-binding protein (PBP). Carumonam exerts highly activity against Enterobacteriaceae, Pseudomonas aeruginosa, and Haemophilus influenzae, while it weakly and even inactively inhibits Streptococcus pneumoniae and Staphylococcus aureus. Carumonam is resistant to beta-lactamase-mediated hydrolysis^[1].

Carumonam shows inhibition against Enterobacteriaceae isolates with MIC₉₀ values of 0.013-25 μg/mL, while it inhibits P. aeruginosa with a MIC₉₀ value of 12.5 μg/mL^[1].
Carumonam (0-400 μg/mL) has high affinity to binding PBP-3 in Enterobacteriaceae and P. aeruginosa with IC₅₀s as same with or smaller than the MICs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Carumonam (20 mg/kg; s.c. or i.m.; single dose) is easily absorbed and distributes in high concentrations in plasma, kidneys, liver and lungs in pharmacokinetic analysis in mice, rats, rabbits, dogs and cynomolgus monkeys^[2].
Animal: Five-week-old male Slc:ICR mice (20-25 g), 7-week-old male Jcl:SD rats (210-250 g), male New Zealand White rabbits (2.5-3.5 kg), male and female beagle dogs (10-15 kg), and female cynomolgus monkeys (2.8-3.7 kg). They are deprived of feed for 16 to 18 h before the antibiotic was administered; water was given ad libitum^[2].

Pharmacokinetic Analysis^[2]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

466.40

C₁₂H₁₄N₆O₁₀S₂

87638-04-8

O=C(CO/N=C(C(N[C@H]1[C@H](N(C1=O)S(=O)(O)=O)COC(N)=O)=O)/C2=CSC(N)=N2)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Imada A, et al. In vitro and in vivo antibacterial activities of carumonam (AMA-1080), a new N-sulfonated monocyclic beta-lactam antibiotic. Antimicrob Agents Chemother. 1985 May;27(5):821-7.  [Content Brief]

  [2]. Kita Y, et al. Comparative pharmacokinetics of carumonam and aztreonam in mice, rats, rabbits, dogs, and cynomolgus monkeys. Antimicrob Agents Chemother. 1986 Jan;29(1):127-34.  [Content Brief]