Carumonam disodium
Carumonam disodium is a potent antibiotic. Carumonam disodium shows antibacterial activity. Carumonam disodium induces seizure.
For research use only. We do not sell to patients.
- CAS No.: 86832-68-0
- Formula: C12H12N6Na2O10S2
- Molecular Weight:510.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Antibiotic Isoforms
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Biological Activity
Carumonam disodium (0-100 µg/mL) shows antibacterial activity with MIC90s of 0.2, 3.13, 0.2, 0.39, 0.2, 6.25, 0.2, 3.13, 0.05, 0.025, 0.78, 0.013, 0.025 µg/mL for Escherichia coli (cefazolin sensitive), Escherichia coli (cefazolin resistant), Klebsiella pneumoniae (cefazolin sensitive), Klebsiella pneumoniae (cefazolin resistant), Klebsiella oxytoca, Enterobacter cloacae, Serratia marcescens (gentamicin sensitive), Serratia marcescens (gentamicin resistant), Proteus vulgaris, Proteus mirabilis, Proteus morganii, Proteus rettgeri, Proteus inconstans, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:16-24g, 42-48 days DBA/2; 18-28, 42-48 days Swiss and C57 mice[2]
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Dosage:1.31-6.89 mmol/kg
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Administration:I.p.
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Result:Induced seizure in DBA/2, Swiss and C57 mice.
Chemical Information
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CAS No. 86832-68-0
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Molecular Weight 510.37
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Formula C12H12N6Na2O10S2
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SMILES
NC(OC[C@H]1N(C([C@H]1NC(/C(C2=CSC(N)=N2)=N\OCC(O[Na])=O)=O)=O)S(=O)(O[Na])=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Imada A, et al. In vitro and in vivo antibacterial activities of carumonam (AMA-1080), a new N-sulfonated monocyclic beta-lactam antibiotic. Antimicrob Agents Chemother. 1985 May;27(5):821-7. [Content Brief]
[2]. De Sarro A, et al. Comparative epileptogenic properties of two monobactam derivatives in C57, Swiss and DBA/2 mice. J Antimicrob Chemother. 1996 Sep;38(3):475-84. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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