87638-04-8
Chemical Structure
Carumonam
Synonym(s): AMA-1080; Ro 17-2301
- CAS No.: 87638-04-8
- Formula:C12H14N6O10S2
- Molecular Weight:466.40
IUPAC Name: 2-((((Z)-1-(2-aminothiazol-4-yl)-2-(((2S,3S)-2-((carbamoyloxy)methyl)-4-oxo-1-sulfoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)acetic acid
InChIKey: UIMOJFJSJSIGLV-JNHMLNOCSA-N
SMILES: O=C(CO/N=C(C(N[C@H]1[C@H](N(C1=O)S(=O)(O)=O)COC(N)=O)=O)/C2=CSC(N)=N2)O
Biological Activity: Carumonam (AMA-1080; Ro 17-2301) is a sulfonated monocyclic β-Lactam Antibiotic, targeting to penicillin-binding protein (PBP). Carumonam exerts highly activity against Enterobacteriaceae, Pseudomonas aeruginosa, and Haemophilus influenzae, while it weakly and even inactively inhibits Streptococcus pneumoniae and Staphylococcus aureus. Carumonam is resistant to beta-lactamase-mediated hydrolysis[1].
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Carumonam | Carumonam (AMA-1080; Ro 17-2301) is a sulfonated monocyclic β-Lactam Antibiotic, targeting to penicillin-binding protein (PBP). Carumonam exerts highly activity against Enterobacteriaceae, Pseudomonas aeruginosa, and Haemophilus influenzae, while it weakly and even inactively inhibits Streptococcus pneumoniae and Staphylococcus aureus. Carumonam is resistant to beta-lactamase-mediated hydrolysis. | |||||||||||||||||||||
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Keywords
