91 Results for "

cytotoxic alkaloid

" in MedChemExpress (MCE) Product Catalog:
Products (91)

91 Results for "cytotoxic alkaloid" in MCE Product Catalog:

48
Monocrotaline
Monocrotaline
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48 Publications Verification
Cat. No.: HY-N0750
CAS No.: 315-22-0
Synonyms: Crotaline
Category:  

Alkaloids Pyrrole Alkaloids Leguminosae Plants Crotalaria pallida Ait. Disease Research Fields Cancer

Target:  

Others

Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC50s of 36.8 µM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. [2][6][8].
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47
Dehydrocorydaline
Dehydrocorydaline
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47 Cited Publications
Cat. No.: HY-N0674
CAS No.: 30045-16-0
Synonyms: 13-Methylpalmatine
Category:  

Infection Alkaloids Corydalis yanhusuo W. T. Wang Plants Disease Research Fields Isoquinoline Alkaloids Papaveraceae

Target:  

Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy

Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .
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47
Dehydrocorydaline chloride
Dehydrocorydaline chloride
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47 Cited Publications
Cat. No.: HY-N0674A
CAS No.: 10605-03-5
Synonyms: 13-Methylpalmatine chloride
Category:  

Infection Alkaloids other families Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy

Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline chloride shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .
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46
Dehydrocorydaline (hydroxyl)
Dehydrocorydaline (hydroxyl)
0 Images
46 Cited Publications
Cat. No.: HY-N0674B
Synonyms: 13-Methylpalmatine (hydroxyl)
Category:  

Alkaloids Corydalis yanhusuo W. T. Wang Plants Papaveraceae

Target:  

Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy

Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.
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45
Dehydrocorydaline nitrate
Dehydrocorydaline nitrate
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45 Cited Publications
Cat. No.: HY-N4238
CAS No.: 13005-09-9
Synonyms: 13-Methylpalmatine nitrate
Category:  

Infection Alkaloids other families Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy

Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. . Dehydrocorydaline nitrate shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .
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37
Homoharringtonine
Homoharringtonine
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37 Cited Publications
Cat. No.: HY-14944
CAS No.: 26833-87-4
Purity:  99.75%
Synonyms: Omacetaxine mepesuccinate; HHT
Category:  

Alkaloids Pyrrole Alkaloids Plants Cephalotaxaceae Disease Research Fields Cancer Cephalotaxus fortunei Hooker

Target:  

STAT

Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.
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20
Vinblastine sulfate
Vinblastine sulfate
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20 Cited Publications
Cat. No.: HY-13780
CAS No.: 143-67-9
Purity:  99.86%
Synonyms: Vincaleukoblastine sulfate salt
Category:  

Apocynaceae Alkaloids Plants Disease Research Fields Cancer Alkaloid Dimers Catharanthus roseus (L.) G. Don

Target:  

Microtubule/Tubulin nAChR Autophagy

Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.
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4
Jatrorrhizine chloride
Jatrorrhizine chloride
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4 Cited Publications
Cat. No.: HY-N0740
CAS No.: 6681-15-8
Category:  

Alkaloids Monophenols Ranunculaceae Coptis chinensis Franch. Phenols Plants Isoquinoline Alkaloids

Target:  

Cholinesterase (ChE) 5-HT Receptor Bacterial

Jatrorrhizine chloride is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .
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4
Skimmianine
Skimmianine
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4 Cited Publications
Cat. No.: HY-N2081
CAS No.: 83-95-4
Category:  

Alkaloids Rutaceae Quinoline Alkaloids Plants Skimmia reevesiana Fort. Disease Research Fields Inflammation/Immunology

Target:  

Cholinesterase (ChE) PI3K Akt NF-κB

Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC50 = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca 2+ signaling and protein kinase C signaling .
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4
Jatrorrhizine hydroxide
Jatrorrhizine hydroxide
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4 Cited Publications
Cat. No.: HY-N0749A
CAS No.: 483-43-2
Category:  

Alkaloids Monophenols Ranunculaceae Coptis chinensis Franch. Phenols Plants Isoquinoline Alkaloids

Target:  

Cholinesterase (ChE) 5-HT Receptor Bacterial

Jatrorrhizine hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .
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2
Chelidonine
Chelidonine
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2 Cited Publications
Cat. No.: HY-N2369
CAS No.: 476-32-4
Category:  

Infection Alkaloids Chelidonium majus Plants Disease Research Fields Isoquinoline Alkaloids Papaveraceae

Target:  

Apoptosis Influenza Virus

Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L.. Chelidonine causes G2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity .
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2
Aaptamine
Aaptamine
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2 Cited Publications
Cat. No.: HY-N4225
CAS No.: 85547-22-4
Category:  

Alkaloids Animals Marine natural products Quinoline Alkaloids Sponge Disease Research Fields Endocrinology

Target:  

Adrenergic Receptor Proteasome Cholinesterase (ChE) Bacterial Apoptosis AP-1 NF-κB

Aaptamine is an alkaloid that can be isolated from the sponge Aaptos suberitoides. Aaptamine is a competitive antagonist of the α-adrenergic receptor, as well as an inhibitor of the proteasome and cholinesterase. Aaptamine is cytotoxic to tumor cells and can induce apoptosis, cell cycle arrest of tumor cells, and the expression of p21 through a p53-independent pathway. Aaptamine has multiple activities such as anti-tumor, antioxidant, antibacterial, and analgesic effects .
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1
Hirsutine
Hirsutine
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1 Cited Publications
Cat. No.: HY-N2193
CAS No.: 7729-23-9
Category:  

Infection Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Disease Research Fields Indole Alkaloids

Target:  

Flavivirus Dengue Virus Apoptosis

Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity .
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1
(+)-Intermedine
(+)-Intermedine
0 Images
1 Cited Publications
Cat. No.: HY-113845
CAS No.: 10285-06-0
Purity:  ≥99.0%
Category:  

Alkaloids Pyrrole Alkaloids Plants Symphytum officinale L. Boraginaceae

Target:  

Others

(+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .
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Haemanthamine
Haemanthamine
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Cat. No.: HY-114489A
CAS No.: 466-75-1
Purity:  95.10%
Category:  

Infection Alkaloids Neurological Disease Plants Sprekelia formosissima (L.) Herb. Disease Research Fields Isoquinoline Alkaloids Amaryllidaceae

Target:  

Apoptosis Influenza Virus Parasite

Haemanthamine is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities .
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Pellitorine
Pellitorine
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Cat. No.: HY-N3097
CAS No.: 18836-52-7
Category:  

Alkaloids Other Alkaloids Piperaceae Plants Disease Research Fields Piper nigrum Linn. Biological Pesticide Research Cancer Agricultural Research

Target:  

TRP Channel Amyloid-β Toll-like Receptor (TLR) Keap1-Nrf2 Heme Oxygenase (HO) Dihydroorotate Dehydrogenase Ferroptosis PAI-1 NF-κB ERK Proton Pump Glutathione Peroxidase Thrombin Insecticide Bacterial

Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria .
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Jatrorrhizine
Jatrorrhizine
0 Images
Cat. No.: HY-N0749
CAS No.: 3621-38-3
Category:  

Alkaloids other families Monophenols Phenols Plants Isoquinoline Alkaloids

Target:  

Cholinesterase (ChE) 5-HT Receptor Bacterial

Jatrorrhizine is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .
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Jineol
Jineol
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Cat. No.: HY-119529
CAS No.: 178762-28-2
Purity:  99.68%
Synonyms: 3,8-Quinolinediol
Category:  

Alkaloids Animals Quinoline Alkaloids Disease Research Fields Cancer

Target:  

Tyrosinase Bacterial

Jineol is a cytotoxic alkaloid from the centipede Scolopendra subspinipes. Jineol exhibits modest cytotoxic activity in vitro against the growth of human tumor cell lines .
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Vinblastine sulfate (Standard)
Vinblastine sulfate (Standard)
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Cat. No.: HY-13780R
CAS No.: 143-67-9
Synonyms: Vincaleukoblastine sulfate salt (Standard)
Category:  

Apocynaceae Alkaloids Plants Alkaloid Dimers Catharanthus roseus (L.) G. Don

Target:  

Reference Standards Microtubule/Tubulin Autophagy nAChR

Vinblastine (sulfate) (Standard) is the analytical standard of Vinblastine (sulfate). This product is intended for research and analytical applications. Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.
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Humantenine
Humantenine
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Cat. No.: HY-N4031
CAS No.: 82375-29-9
Category:  

Alkaloids Other Diseases Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Disease Research Fields Indole Alkaloids

Target:  

Anaplastic lymphoma kinase (ALK) METTL3

Humantenine is a highly toxic indole alkaloid from Gelsemium elegans (Gardn. & Champ.) Benth. that binds to RNA m6A modification regulatory proteins (ALKBH5, METTL). Humantenine stably binds via hydrogen bonding and hydrophobic interactions and disrupts the m6A methylation level of target genes, thereby impairing the expression of intestinal epithelial cell tight junction and cytoskeleton-related genes, causing intestinal barrier dysfunction and significant intestinal cytotoxicity. The intraperitoneal injection LD50 values of Humantenine are <1 mg/kg in mice, 1.2 mg/kg in male rats and 1.5 mg/kg in female rats, respectively. Species differences exist in the metabolism of Humantenine in human, porcine, goat and rat liver microsomes, and demethylation, dehydrogenation and oxidation occur in liver microsomes .
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