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Results for "

cytotoxic alkaloid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) ADC Payload (1) Adrenergic Receptor (1) Akt (2) Amyloid-β (2) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (1) AP-1 (1) Apoptosis (12) Arp2/3 Complex (1) Autophagy (6) Bacterial (16) Bcl-2 Family (5) Caspase (5) Cholinesterase (ChE) (9) Dengue Virus (1) Dihydroorotate Dehydrogenase (2) Drug Derivative (3) DYRK (1) Endogenous Metabolite (4) ERK (1) Ferroptosis (2) Flavivirus (1) Fungal (2) Glutathione Peroxidase (2) GSK-3 (1) Heme Oxygenase (HO) (2) HIV (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (5) Insecticide (3) Interleukin Related (2) Keap1-Nrf2 (2) Melanocortin Receptor (1) METTL3 (1) Microtubule/Tubulin (4) MyD88 (1) nAChR (2) NF-κB (8) P-glycoprotein (1) p38 MAPK (5) PAI-1 (2) Parasite (9) PARP (4) Phosphodiesterase (PDE) (1) PI3K (2) Prolyl Endopeptidase (PREP) (1) Proteasome (1) Proton Pump (2) Reactive Oxygen Species (ROS) (2) Reference Standards (7) STAT (2) Thrombin (2) TNF Receptor (2) Toll-like Receptor (TLR) (3) Topoisomerase (1) TRP Channel (2) Tyrosinase (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (63) Cardiovascular Disease (3) Endocrinology (2) Infection (26) Inflammation/Immunology (17) Metabolic Disease (2) Neurological Disease (14)

By Targets:

5-HT Receptor (4)

ADC Payload (1)

Adrenergic Receptor (1)

Akt (2)

Amyloid-β (2)

Anaplastic lymphoma kinase (ALK) (1)

Antibiotic (1)

AP-1 (1)

Apoptosis (12)

Arp2/3 Complex (1)

Autophagy (6)

Bacterial (16)

Bcl-2 Family (5)

Caspase (5)

Cholinesterase (ChE) (9)

Dengue Virus (1)

Dihydroorotate Dehydrogenase (2)

Drug Derivative (3)

DYRK (1)

Endogenous Metabolite (4)

ERK (1)

Ferroptosis (2)

Flavivirus (1)

Fungal (2)

Glutathione Peroxidase (2)

GSK-3 (1)

Heme Oxygenase (HO) (2)

HIV (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Influenza Virus (5)

Insecticide (3)

Interleukin Related (2)

Keap1-Nrf2 (2)

Melanocortin Receptor (1)

METTL3 (1)

Microtubule/Tubulin (4)

MyD88 (1)

nAChR (2)

NF-κB (8)

P-glycoprotein (1)

p38 MAPK (5)

PAI-1 (2)

Parasite (9)

PARP (4)

Phosphodiesterase (PDE) (1)

PI3K (2)

Prolyl Endopeptidase (PREP) (1)

Proteasome (1)

Proton Pump (2)

Reactive Oxygen Species (ROS) (2)

Reference Standards (7)

STAT (2)

Thrombin (2)

TNF Receptor (2)

Toll-like Receptor (TLR) (3)

Topoisomerase (1)

TRP Channel (2)

Tyrosinase (1)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (63)

Cardiovascular Disease (3)

Endocrinology (2)

Infection (26)

Inflammation/Immunology (17)

Metabolic Disease (2)

Neurological Disease (14)

Inhibitors & Agonists

Natural
Products

Targets Recommended: CTLA-4

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-14944

Homoharringtonine 30+ Cited Publications Omacetaxine mepesuccinate; HHT	STAT	Cancer
Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.

HY-N0750

Monocrotaline Maximum Cited Publications 44 Publications Verification Crotaline	Others	Infection Metabolic Disease Cancer
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC₅₀s of 36.8 µM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. ^[2][6][8].

HY-13780

Vinblastine sulfate 15+ Cited Publications Vincaleukoblastine sulfate salt	Microtubule/Tubulin nAChR Autophagy	Cancer
Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC₅₀ of 8.9 μM.

HY-N0674

Dehydrocorydaline Maximum Cited Publications 44 Publications Verification 13-Methylpalmatine	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy	Infection Cancer
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline shows strong anti-malarial effects (IC₅₀=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-114489A

Haemanthamine	Apoptosis Influenza Virus Parasite	Infection Neurological Disease Cancer
Haemanthamine is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities .

HY-N0740

Jatrorrhizine chloride 3 Publications Verification	Cholinesterase (ChE) 5-HT Receptor Bacterial	Neurological Disease Inflammation/Immunology
Jatrorrhizine chloride is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of?AChE?(IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-N2193

Hirsutine 1 Publications Verification	Flavivirus Dengue Virus Apoptosis	Infection Cancer
Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity .

HY-N2081

Skimmianine 3 Publications Verification	Cholinesterase (ChE) PI3K Akt NF-κB	Neurological Disease Inflammation/Immunology Cancer
Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC₅₀ = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca ²⁺ signaling and protein kinase C signaling .

HY-N3097

Pellitorine	TRP Channel Amyloid-β Toll-like Receptor (TLR) Keap1-Nrf2 Heme Oxygenase (HO) Dihydroorotate Dehydrogenase Ferroptosis PAI-1 NF-κB ERK Proton Pump Glutathione Peroxidase Thrombin Insecticide Bacterial	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria .

HY-N0749

Jatrorrhizine	Cholinesterase (ChE) 5-HT Receptor Bacterial	Neurological Disease
Jatrorrhizine is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine is a potent and orally active inhibitor of AChE (IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-N2369

Chelidonine 2 Publications Verification	Apoptosis Influenza Virus	Infection Neurological Disease Inflammation/Immunology Cancer
Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L.. Chelidonine causes G_2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity .

HY-N0674A

Dehydrocorydaline chloride Maximum Cited Publications 44 Publications Verification 13-Methylpalmatine chloride	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy	Infection Cancer
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline chloride shows strong anti-malarial effects (IC₅₀?=38 nM), and low cytotoxicity (cell viability?>?90%) using P. falciparum 3D7 strain .

HY-N4225

Aaptamine 2 Publications Verification	Adrenergic Receptor Proteasome Cholinesterase (ChE) Bacterial Apoptosis AP-1 NF-κB	Infection Neurological Disease Inflammation/Immunology Endocrinology Cancer
Aaptamine is an alkaloid that can be isolated from the sponge Aaptos suberitoides. Aaptamine is a competitive antagonist of the α-adrenergic receptor, as well as an inhibitor of the proteasome and cholinesterase. Aaptamine is cytotoxic to tumor cells and can induce apoptosis, cell cycle arrest of tumor cells, and the expression of p21 through a p53-independent pathway. Aaptamine has multiple activities such as anti-tumor, antioxidant, antibacterial, and analgesic effects .

HY-N0749A

Jatrorrhizine hydroxide 3 Publications Verification	Cholinesterase (ChE) 5-HT Receptor Bacterial	Neurological Disease Inflammation/Immunology
Jatrorrhizine hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE (IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-119529

Jineol 3,8-Quinolinediol	Tyrosinase Bacterial	Cancer
Jineol is a cytotoxic alkaloid from the centipede Scolopendra subspinipes. Jineol exhibits modest cytotoxic activity in vitro against the growth of human tumor cell lines .

HY-13780R

Vinblastine sulfate (Standard) Vincaleukoblastine sulfate salt (Standard)	Reference Standards Microtubule/Tubulin Autophagy nAChR	Cancer
Vinblastine (sulfate) (Standard) is the analytical standard of Vinblastine (sulfate). This product is intended for research and analytical applications. Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC₅₀ of 8.9 μM.

HY-N4031

Humantenine	Anaplastic lymphoma kinase (ALK) METTL3	Inflammation/Immunology
Humantenine is a highly toxic indole alkaloid from Gelsemium elegans (Gardn. & Champ.) Benth. that binds to RNA m6A modification regulatory proteins (ALKBH5, METTL). Humantenine stably binds via hydrogen bonding and hydrophobic interactions and disrupts the m6A methylation level of target genes, thereby impairing the expression of intestinal epithelial cell tight junction and cytoskeleton-related genes, causing intestinal barrier dysfunction and significant intestinal cytotoxicity. The intraperitoneal injection LD₅₀ values of Humantenine are <1 mg/kg in mice, 1.2 mg/kg in male rats and 1.5 mg/kg in female rats, respectively. Species differences exist in the metabolism of Humantenine in human, porcine, goat and rat liver microsomes, and demethylation, dehydrogenation and oxidation occur in liver microsomes .

HY-N8420

Thalifoline	Fungal	Infection Cancer
Thalifoline is an isoquinoline alkaloid. Thalifoline exerts cytotoxic effects on cancer cells. Thalifoline inhibits the growth of Fusarium oxysporum f. sp. lycopersici. Thalifoline can be used in research related to lung adenocarcinoma, colon cancer, oral epidermoid carcinoma, and fungal infections .

HY-N9488

Girinimbine Girinimbin	Apoptosis Bacterial Parasite	Infection Inflammation/Immunology Cancer
Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities .

HY-N0674B

Dehydrocorydaline (hydroxyl) 40+ Cited Publications 13-Methylpalmatine (hydroxyl)	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy	Infection Inflammation/Immunology Cancer
Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

HY-N4238

Dehydrocorydaline nitrate 40+ Cited Publications 13-Methylpalmatine nitrate	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy	Infection Cancer
Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. . Dehydrocorydaline nitrate shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N4012

Indole-3-glyoxylamide 3-Indoleglyoxamide	Others	Others
Indole-3-glyoxylamide (Compound 4) is a type of indole alkaloid. Indole-3-glyoxylamide shows no significant cytotoxic activity against Hela, Ishikawa, and MGC-803 cells .

HY-N7596

Isoverticine	Others	Cancer
Isoverticine, a bioactive isosteroidal alkaloid isolated from bulbus of Fritillaria pallidiflora, displays significant cytotoxicity .

HY-N9338

Guattegaumerine	Others	Neurological Disease
Guattegaumerine is a bisbenzylisoquinoline alkaloid?with antimitotic, cytotoxic and neuroprotective activities .

HY-130995

Agrochelin	Antibiotic ADC Payload	Infection
Agrochelin, an alkaloid cytotoxic antibiotic, is produced by the fermentation of a marine Agrobacterium sp. Agrochelin has cytotoxic activity in tumor cell lines .

HY-N6622

Tazettine	Others	Others
Tazettine is an alkaloid with low cytotoxicity to mammalian cell lines (CC50 >100 μg/mL) .

HY-N9339

Norglaucine (+)-Norglaucine	Others	Cancer
Norglaucine ((+)-Norglaucine), a **cytotoxic alkaloid*, exhibits cytotoxicity* towards the tumor cell lines B16-F10, HepG2, K562 and HL-60 cells .

HY-N16573

19-epi-Voacristine	Others	Cancer
19-epi-Voacristine is an indole alkaloid. 19-epi-Voacristine exhibits cytotoxic activity against the A2780 ovarian cancer cell line .

HY-14944R

Homoharringtonine (Standard) Omacetaxine mepesuccinate (Standard); HHT (Standard)	Reference Standards STAT	Cancer
Homoharringtonine (Standard) is the analytical standard of Homoharringtonine. This product is intended for research and analytical applications. Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.

HY-N2892

Aristolactam A IIIa Aristololactam A IIIa; Sch 546909	DYRK	Cardiovascular Disease Cancer
Aristolactam A IIIa (Sch 546909) is an aristolactam-type alkaloid that can be isolated from Glycosmis chlorosperma. Aristolactam A IIIa is a DYRK1A Inhibitor. Aristolactam A IIIa inhibits platelet aggregation induced by arachidonic acid (AA), collagen and platelet-activating factor (PAF). Aristolactam A IIIa has strong cytotoxic effect on HeLa cells .

HY-N7183

9-Hydroxycanthin-6-one	NF-κB GSK-3 β-catenin Wnt	Cancer
9-Hydroxycanthin-6-one is a β-carboline alkaloid. 9-Hydroxycanthin-6-one can be isolated from the roots of E. longifolia. 9-Hydroxycanthin-6-one inhibits TNF-α-induced activation of the NF-κB pathway. 9-Hydroxycanthin-6-one activates GSK3β independently of CK1α, drives phosphorylation and degradation of β-catenin, and inhibits the Wnt signaling pathway. 9-Hydroxycanthin-6-one exerts selective cytotoxicity against Wnt-dependent colon cancer cells. 9-Hydroxycanthin-6-one can be used in studies related to colon cancer .

HY-116786

11-Hydroxycanthin-6-one	Drug Derivative	Cancer
11-Hydroxycanthin-6-one, a canthin-6-one (HY-N3536) alkaloid, is an antitumor agent which shows potent cytotoxic activity .

HY-N5002

(+)-Viroallosecurinine	Bacterial	Infection
(+)-Viroallosecurinine, a cytotoxic alkaloid, exhibits a MIC of 0.48 μg/mL for Ps. Aeruginosa and Staph. aureus . Antibacterial activity .

HY-N2570

Corytuberine	Others	Cancer
Corytuberine is an aporphine alkaloid found in Dicranostigma leptopodum. Corytuberine displays cytotoxicity against SMMC-7721 tumor cells .

HY-114489B

Haemanthamine hydrochloride	Apoptosis Influenza Virus Parasite	Infection Neurological Disease Cancer
Haemanthamine hydrochloride is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine hydrochloride targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine hydrochloride has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities .

HY-N2369R

Chelidonine (Standard)	Reference Standards Apoptosis Influenza Virus	Infection Cancer
Chelidonine (Standard) is the analytical standard of Chelidonine. This product is intended for research and analytical applications. Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L.. Chelidonine causes G2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity .

HY-158721

Penicinoline Marinamide	Endogenous Metabolite Parasite	Infection Cancer
Penicinoline (Marinamide) (Compound 1), a pyrrolyl 4-quinolinone alkaloid, is a microbial secondary metabolite. Penicinoline can be isolated from endophytic fungus Penicillium sp. Penicinoline has antimalarial activity against Chloroquine (HY-17589A) sensitive strain (pf3d7) and against Chloroquine resistant strain (pfDd2) of plasmodium falciparum. Penicinoline also has strong insecticidal activity against Aphis gossypii and selective anticancer effect with significant cytotoxicity for 95-D and HepG2 cells .

HY-W437569

Melicopine	Parasite Insecticide	Infection Cancer
Melicopine is an alkaloid found in Z. simulans with antimalarial and anticancer activities. It exhibits inhibitory activity against chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum, with IC₅₀ values of 29.7 and 33.7 µg/mL, respectively. Melicopine is cytotoxic to prostate cancer cells PC-3M and LNCaP (IC₅₀ values of 47.9 and 37.8 µg/mL), but has no effect on non-cancerous HEK293 cells (IC₅₀ greater than 100 µg/mL). Melicopine holds promise for research in anticancer and anti-infection fields .

HY-N3700

Decarine Rutaceline	Bacterial HIV TNF Receptor Interleukin Related	Infection Inflammation/Immunology
Decarine (Rutaceline) is a benzophenanthridine alkaloid found in Zanthoxylum species. Decarinewith shows anti-inflammatory, antimycobacterial, and anti-HIV activity. Decarine inhibits NO, TNF-α, IL-1β, IL-6, and IL-8 production in inflammatory cell models. Decarine inhibits growth of Mycobacterium tuberculosis strains, reduces intracellular Mycobacterium tuberculosis survival, and shows low cytotoxicity toward human macrophages. Decarine inhibits HIV replication in acutely infected lymphocytes. Decarine can be used for the researches of inflammation, tuberculosis, and HIV infection .

HY-N2081R

Skimmianine (Standard)	Reference Standards Cholinesterase (ChE) PI3K Akt NF-κB	Neurological Disease Inflammation/Immunology Cancer
Skimmianine (Standard) is the analytical standard of Skimmianine. This product is intended for research and analytical applications. Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC₅₀ = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca ²⁺ signaling and protein kinase C signaling .

HY-N9161

Echitoveniline	Others	Cancer
Echitoveniline, a monoterpenoid indole alkaloid, can be isolated from Alstonia mairei. Echitoveniline has no significant cytotoxicity against cancer cells (IC₅₀: > 40 μM) .

HY-118726

Luotonin F	Topoisomerase	Cancer
Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human topoisomerase II .

HY-N3123

Oxychelerythrine Dihydrooxochelerythrine	Others	Cancer
Oxychelerythrine is an alkaloid that can be isolated from Zanthoxylum integrifoliolum. Oxychelerythrine exhibits cytotoxicity against P-388 and HT-29 cell lines with ED₅₀s of 3.25 and 5.48 μg/mL, respectively .

HY-N9534

Xylopine	Reactive Oxygen Species (ROS) Apoptosis	Cancer
Xylopine is an aporphine alkaloid with cytotoxic activity on cancer cells. Xylopine induces oxidative stress, causes G2/M cell cycle arrest and apoptosis in cancer cells .

HY-N3179

Norcepharadione B	Others	Others
Norcepharadione B is an alkaloid that can be isolated from Houttuynia cordata. Norcepharadione B exhibits moderate cytotoxicity against A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 cell line with ED₅₀s of 40, 26.4, 40, 14.2 and 38.2 μg/mL, respectively .

HY-N15580

Turneforcidine (-)-Turneforcidine	Others	Cancer
Turneforcidine ((-)-Turneforcidine) is a pyrrolizidine alkaloid with antitumor and cytotoxic activity .

HY-113845

(+)-Intermedine 1 Publications Verification	Others	Neurological Disease
(+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .

HY-N2483

Hydroprotopine	Others	Cancer
Hydroprotopine is a alkaloid from Hypecoum leptocarpumand. Leptopidine can suppress growth and induce cytotoxicity in breast cancer cells and that the cytotoxicity of leptopidine may be related to its inhibitory effect on fatty acid synthase expression .

HY-116529

Lamellarin E	Others	Others
Lamellarin E is a biologically active marine alkaloid, while the Lamellarin series of alkaloids show potential cytotoxicity, topoisomerase I inhibition, protein kinase inhibition, multidrug resistance reversal, and anti-HIV-1 activity .

HY-N12192

Ebenifoline E-II	Others	Others
Ebenifoline E-II (Compound 2) is a sesquiterpene alkaloid derived from Euonymus laxiflorus. Ebenifoline E-II is cytotoxic .

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cytotoxic alkaloid

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