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  3. Plants Alkaloids
  4. Calycanthacerae Other Alkaloids
  5. Chimonanthus praecox (L.)Link
  6. (-)-Folicanthine

(-)-Folicanthine is a dimeric tryptamine-related alkaloid found in the fruits of Chimonanthus praecox. (-)-Folicanthine shows cytotoxic against cancer cells. (-)-Folicanthine can be used for the research of cancer, such as gastric carcinoma and hepatocarcinoma.

For research use only. We do not sell to patients.

(-)-Folicanthine

(-)-Folicanthine Chemical Structure

CAS No. : 6879-55-6

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(-)-Folicanthine Related Antibodies

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Description

(-)-Folicanthine is a dimeric tryptamine-related alkaloid found in the fruits of Chimonanthus praecox. (-)-Folicanthine shows cytotoxic against cancer cells. (-)-Folicanthine can be used for the research of cancer, such as gastric carcinoma and hepatocarcinoma[1].

In Vitro

(-)-Folicanthine (Compound 12) (72 h) exhibits cytotoxic activity against human gastric carcinoma NUGC3 cells, human hepatocarcinoma SNU739 cells, and human neuroblastoma SHSY-5Y cells, with IC50 values of 13.3 ± 1.5 μM, 17.0 ± 2.8 μM, and 60.1 ± 3.5 μM respectively, and shows no significant cytotoxicity against human breast cancer MCF-7 cells (IC50 >100 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-Folicanthine Related Antibodies

Cell Viability Assay[1]

Cell Line: human gastric carcinoma NUGC3 cells, human hepatocarcinoma SNU739 cells, human neuroblastoma SHSY-5Y cells, human breast cancer MCF-7 cells
Concentration: 0-100 μM
Incubation Time: 72 h
Result: Exhibited cytotoxic activity with an IC50 of 13.3 ± 1.5 μM against NUGC3 cells.
Exhibited cytotoxic activity with an IC50 of 17.0 ± 2.8 μM against SNU739 cells.
Exhibited cytotoxic activity with an IC50 of 60.1 ± 3.5 μM against SHSY-5Y cells.
Showed no significant cytotoxicity against MCF-7 cells with an IC50 >100 μM.
Molecular Weight

374.52

Formula

C24H30N4
CAS No.
SMILES

CN1[C@]2([H])[C@](CCN2C)([C@@]34[C@@](N(CC4)C)([H])N(C5=CC=CC=C53)C)C6=CC=CC=C61
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(-)-Folicanthine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Folicanthine6879-55-6Othershuman gastric carcinoma cellsSNU739 cellsNUGC3 cellshuman neuroblastoma cellshepatocarcinomaSHSY-5Y cellshuman hepatocarcinoma cellshuman breast cancer cellsgastric carcinomaChimonanthus praecoxInhibitorinhibitorinhibit

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