1. Apoptosis
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  3. Haemanthamine hydrochloride

Haemanthamine hydrochloride 

Cat. No.: HY-114489B
Handling Instructions

Haemanthamine hydrochloride is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine hydrochloride targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine hydrochloride has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities.

For research use only. We do not sell to patients.

Haemanthamine hydrochloride Chemical Structure

Haemanthamine hydrochloride Chemical Structure

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Description

Haemanthamine hydrochloride is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine hydrochloride targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine hydrochloride has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities[1][2].

In Vitro

Haemanthamine (1-100 µM; 24-48 hours; A2780 cells) treatment shows a time- and dose-dependent decrease in cell viability[2].
Haemanthamine (10 µM; 24-72 hours; A2780 cells) treatment leads to a significant inhibition of A2780 cell proliferation[2].
Haemanthamine binds at the A-site cleft of the peptidyl transferase center on the large ribosomal subunit, creating unique molecular interactions with the 25S rRNA. Haemanthamine has a highly specific inhibitory effect on pre-rRNA processing, leading to the activation of a p53-dependent antitumoral surveillance pathway known as nucleolar stress[1].

Cell Viability Assay[2]

Cell Line: A2780 ovarian cancer cells
Concentration: 1 µM, 10 µM, 50 µM, 100 µM
Incubation Time: 24 hours, 48 hours
Result: Showed a time- and dose-dependent decrease in cell viability.

Cell Proliferation Assay[2]

Cell Line: A2780 ovarian cancer cells
Concentration: 1 µM, 10 µM, 50 µM, 100 µM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Led to a significant inhibition of A2780 cell proliferation.
In Vivo

A pharmacokinetic study of Haemanthamine in rats shows a rapid distribution phase of 30 min, a half-life of 70.4 min, and a major clearance through renal elimination. The high distribution volume of 13.7 L/kg suggests a high intracellular penetration, and its plasmatic concentration remains higher than 1 μM for at least 1 hr after a single 10-mg/kg administration[1].

Molecular Weight

337.80

Formula

C₁₇H₂₀ClNO₄

SMILES

O[[email protected]@H](C1)[[email protected]@]2(C=C3)C4=CC(OCO5)=C5C=C4C[[email protected]@]1[[email protected]@]2([H])C[[email protected]@H]3OC.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

HaemanthamineApoptosisInfluenza VirusParasiteAlkaloidanticancerribosomecytotoxicantioxidantantiviralantimalarialanticonvulsantpro-apoptoticantiproliferativeInhibitorinhibitorinhibit

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Haemanthamine hydrochloride
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HY-114489B
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