Guattegaumerine
Guattegaumerine is a bisbenzylisoquinoline alkaloid?with antimitotic, cytotoxic and neuroprotective activities.
For research use only. We do not sell to patients.
- CAS No.: 21446-35-5
- Formula: C36H40N2O6
- Molecular Weight:596.71
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Guattegaumerine (1.25-6.25 μM; 24 hours; 30 min before exposure to serum-starvation+H2O2) significantly increases cell viability at 1.25 and 2.5μM; and guattegaumerine pretreatment significantly inhibits LDH efflux[1].Guattegaumerine (2.5 μM; 24 hours; 30 min before exposure to serum-starvation+H2O2) markedly reduces the oxidative stress-induced apoptosis in rat cortical neurons when compares with the control group[1].Guattegaumerine (1.25-2.5 μM; 24 hours; 30 min before exposure to serum-starvation+H2O2) decreases H2O2 and KCl induced Ca[2+]i increase in cortical neurons[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 21446-35-5
-
Molecular Weight 596.71
-
Formula C36H40N2O6
-
SMILES
COC(C=C(CCN1C)C([C@H]1CC2=CC(OC3=CC=C(C=C3)C[C@@H]4C5=CC(O)=C(OC)C=C5CCN4C)=C(C=C2)O)=C6)=C6O
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Qing Lü, et al. Guattegaumerine protects primary cultured cortical neurons against oxidative stress injury induced by hydrogen peroxide concomitant with serum deprivation. Cell Mol Neurobiol. 2009 May;29(3):355-64. [Content Brief]
[2]. J Leclercq, et al. Antimitotic and cytotoxic activities of guattegaumerine, a bisbenzylisoquinoline alkaloid. Planta Med [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Guattegaumerine Related Classifications
HY-N9338 Related Classifications
Powered by Bioz