Neojiangyouaconitine 

Neojiangyouaconitine is a diterpenoid alkaloid cytotoxin isolated from Aconitum soongaricum var. pubescens. Neojiangyouaconitine exhibits cytotoxic activity against human breast cancer, prostate cancer and lung cancer cells, with weak inhibitory effect on HeLa cells. Neojiangyouaconitine has the ability to kill specific tumor cell lines and can be applied to the research on the mechanisms of related cancers such as breast cancer, prostate cancer and lung cancer^[1].

Neojiangyouaconitine (compound 9) exhibits cytotoxic activity against MCF-7, PC-3 and A549 human tumor cell lines, with IC₅₀ values of 68.7 μM, 40.2 μM and 42.4 μM, respectively; whereas it shows no cytotoxic activity against HeLa cells (IC₅₀>100 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

601.73

C₃₃H₄₇NO₉

126266-35-1

CO[C@@H]1[C@]23[C@@]4([H])[C@]([C@@]5([C@]6([H])[C@@]3([H])C[C@@]([C@@H]6OC(C7=CC=CC=C7)=O)([C@H]([C@@H]5O)OC)O)OC)([H])[C@@H]([C@]2([H])[C@](CN4CC)(CC1)COC)OC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kamil W, et al. Diterpene Alkaloids from Aconitum soongaricum var. pubescens[J]. Chemistry of Natural Compounds, 2017, 53(2): 403-405.